|
Protomap (proteomics)
Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California. Considered a co-inventor of activity based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the nascent field of chemical biology. Cravatt was elected to the National Academy of Sciences in 2014, and the American Academy of Arts and Sciences in 2016. He is Gilula Chair of Chemical Biology, a Cope Scholar, and a Searle Scholar. Early life and education His father was a dentist and his mother a dental hygienist, both of whom instilled in Cravatt an interest in biology as a child. Cravatt entered Stanford University in 1988, graduating in 1992 with a Bachelor of Science, BS in the Biological Sciences and a Bachelor of Arts, BA in History. He then received a Doctor of Philosophy, PhD in Macromolecular and Cellular Structure and Chemistry from The Scripps Research Institute in 1996, whe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Houston
Houston (; ) is the most populous city in Texas, the most populous city in the Southern United States, the fourth-most populous city in the United States, and the sixth-most populous city in North America, with a population of 2,304,580 in 2020. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the seat and largest city of Harris County and the principal city of the Greater Houston metropolitan area, which is the fifth-most populous metropolitan statistical area in the United States and the second-most populous in Texas after Dallas–Fort Worth. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle. Comprising a land area of , Houston is the ninth-most expansive city in the United States (including consolidated city-counties). It is the largest city in the United States by total area whose government is not consolidated with a county, parish, or borough. Though primarily in Harris County, small portions of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dental Hygienist
A dental hygienist or oral hygienist is a licensed dental professional, registered with a dental association or regulatory body within their country of practice. Prior to completing clinical and written board examinations, registered dental hygienists must have either an associate's or bachelor's degree in dental hygiene from an accredited college or university. Once registered, hygienists are primary healthcare professionals who work independently of or alongside dentists and other dental professionals to provide full oral health care. They have the training and education that focus on and specialize in the prevention and treatment of many oral diseases. Dental hygienists have a specific scope of clinical procedures they provide to their patients. They assess a patient's condition in order to offer patient-specific preventive and educational services to promote and maintain good oral health. A major role of a dental hygienist is to perform periodontal therapy which includes thing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly Award In Biological Chemistry
The Eli Lilly Award in Biological Chemistry was established in 1934. Consisting of a bronze medal and honorarium, its purpose is to stimulate fundamental research in biological chemistry by scientists not over thirty-eight years of age. The Award is administered by the Division of Biological Chemistry of the American Chemical Society. Recipients Past recipients of the Lilly Award: *1935 – Willard Myron Allen *1937 – *1938 – *1939 – George Wald *1940 – *1941 – David Rittenberg *1942 – Earl A. Evans, Jr. *1943 – Herbert E. Carter *1944 – Joseph S. Fruton *1945 – *1946 – John D. Ferry *1947 – *1948 – Dilworth Wayne Woolley *1949 – *1950 – *1951 – John M. Buchanan *1952 – *1953 – Nathan O. Kaplan *1954 – Harvey A. Itano *1955 – William F. Neuman *1956 – Robert A. Alberty *1957 – Harold A. Scheraga *1958 – Lester J. Reed *1959 – Paul Berg *1960 – James D. Watson *1961 – *1962 – Jerard Hurwitz *1963 – William ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TR100
The Innovators Under 35 is a peer-reviewed annual award and listicle published by ''MIT Technology Review'' magazine, naming the world's top 35 innovators under the age of 35. at ''Technology Review'' with lists of winners at technologyreview.com Background The subcategories for the awards change from year to year, but generally focus on biomedicine, computing, communications, business, energy, materials, and the web. Nominations are sent from around the world and evaluated by a panel of expert judges. In some years, an Innovator of the Year or a Humanitarian of the Year is also named from among the winners. The purpose of the award is to honor "Exceptionally talented young innovators whose work has the greatest potential to transform the world." History The award was started in 1999 as the TR100, with 100 winners, but was changed to TR35 (35 winners) starting in 2005. The awards are presented to the winners at the annual Emtech conference on emerging technologies, held in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolomics
Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the complete set of metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes. Messenger RNA (mRNA), gene expression data, and proteomics, proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism. There are indeed quantifiable correlations between the metabolome and the other cellular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Activity Based Protein Profiling
Activity-based proteomics, or activity-based protein profiling (ABPP) is a functional proteomic technology that uses chemical probes that react with mechanistically related classes of enzymes. Description The basic unit of ABPP is the probe, which typically consists of two elements: a reactive group (RG, sometimes called a "warhead") and a tag. Additionally, some probes may contain a binding group which enhances selectivity. The reactive group usually contains a specially designed electrophile that becomes covalently-linked to a nucleophilic residue in the active site of an active enzyme. An enzyme that is inhibited or post-translationally modified will not react with an activity-based probe. The tag may be either a reporter such as a fluorophore or an affinity label such as biotin or an alkyne or azide for use with the Huisgen 1,3-dipolar cycloaddition (also known as click chemistry). Advantages A major advantage of ABPP is the ability to monitor the availability of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. There is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immunological protection to the brain inside the skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside the brain and spinal cord. It fills the ventricles of the brain, cisterns, and sulci, as well as the central canal of the spinal cord. There is also a connection from the subarachnoid space to the bony labyrinth of the inner ear via the perilymphat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oleamide
Oleamide is an organic compound with the formula CH3(CH2)7CH=CH(CH2)7CONH2(. It is the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA), it is biosynthesized from N-oleoylglycine. Biochemical and medical aspects In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. It has been considered as a potential treatment for mood and sleep disorders, as well as cannabinoid-regulated depression. In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems. Some in-vitro studies show that the cis enantomer of oleamide is an agnoist for the cannabinoid receptor CB-1 with an affinity around 8 micromolar. However, given oleamide's relatively low affinity for CB-1 and uncertainty about the concentr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Amide Hydrolase
Fatty acid amide hydrolase or FAAH (, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene ''FAAH''.; Function FAAH is an integral membrane hydrolase with a single ''N''-terminal transmembrane domain. ''In vitro'', FAAH has esterase and amidase activity. ''In vivo'', FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of the FAAs include: * Anandamide (''N''-arachidonoylethanolamine), an endocannabinoid * 2-arachidonoylglycerol (2-AG), an endocannabinoid. * Other ''N''-acylethanolamines, such as ''N''-oleoylethanolamine and ''N''-palmitoylethanolamine * The sleep-inducing lipid oleamide * The ''N''-acyltaurines, which are agonists of the transient receptor potential (TRP) family of calcium channels. ''FAAH'' knockout mice display highly elevated (>15-fold) levels of ''N'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary intoxicating compound in cannabis. Cannabidiol (CBD) is a major constituent of temperate Cannabis plants and a minor constituent in tropical varieties. At least 113 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin. It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort, and earlier in Echinacea. Phytocannabinoids are multi-ring phenolic compounds structurally related to THC, but endocannabinoids are fatty acid derivatives. Nonclassical synthetic cannabinoids (cannabimimetics) include amin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and defend their work before a panel of other experts in the field. The completion of a PhD is often a requirement for employment as a university professor, researcher, or scientist in many fields. Individuals who have earned a Doctor of Philosophy degree may, in many jurisdictions, use the title ''Doctor (title), Doctor'' (often abbreviated "Dr" or "Dr.") with their name, although the proper etiquette associated with this usage may also be subject to the professional ethics of their own scholarly field, culture, or society. Those who teach at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.svg "Click for more on -> Houston")
