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Prospect Hill Orthohantavirus
''Prospect Hill orthohantavirus'' is a single-stranded, negative-sense Hantaan-like zoonotic RNA virus isolated from meadow voles and microtine and other cricetid rodents in the United States. It has a widespread distribution in Pennsylvania, Maryland, West Virginia, Minnesota and California. The overall risk of infection in humans is low. It was first isolated from a meadow vole found in Prospect Hill, Maryland for which it is named.Yanagihara R, Daum CA, Lee PW, Baek LJ, Amyx HL, Gajdusek DC, Gibbs CJ Jr.Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA.Trans R Soc Trop Med Hyg. 1987;81(1):42–5. Transmission Transmission to humans is believed to occur through aerosolized inhalation of mouse excreta and possibly through fomite contamination. See also * Isla Vista virus * Hantaan River virus ''Hantaan orthohantavirus'' (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World ''Orthohantavirus''. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bloodland Lake Virus
Bloodland Lake virus (BLLV) is a single-stranded, negative-sense RNA virus of New World ''Orthohantavirus'' first isolated in a Prairie vole (''Microtus ochrogaster'') near Bloodland Lake, Fort Leonard Wood, Pulaski County, Missouri in 1994. BLLV has also been isolated in Prairie voles in St. Louis County, Missouri. Natural reservoir BLLV is unique to the Prairie vole. At the time of its discovery in Pulaski County in 1994, rats and mice trapped along with the Prairie vole tested negative for the virus but did test positive for other hantaviruses. Transmission Transmission is via either direct contact with rodent excreta, or through droplet respiration due to aerosolization of rodent urine, saliva and/or feces. Transmission of hantavirus to humans from arvicoline species in North America has not been documented. To date, the only known transmissions of hantaviruses to humans have come from rats, bats, and mice.Schamljohn, C. S., AND B. Hjelle. 1997. Hantaviruses: a global d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Negative-sense
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, sense may have slightly different meanings. For example, negative-sense strand of DNA is equivalent to the template strand, whereas the positive-sense strand is the non-template strand whose nucleotide sequence is equivalent to the sequence of the mRNA transcript. DNA sense Because of the complementary nature of base-pairing between nucleic acid polymers, a double-stranded DNA molecule will be composed of two strands with sequences that are reverse complements of each other. To help molecular biologists specifically identify each strand individually, the two strands are usually differentiated as the "sense" strand and the "antisense" strand. An individual strand of DNA is referred to as positive-sense (also positive (+) or simply sense) i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoonosis
A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. Typically, the first infected human transmits the infectious agent to at least one other human, who, in turn, infects others. Major modern diseases such as Ebola virus disease and salmonellosis are zoonoses. HIV was a zoonotic disease transmitted to humans in the early part of the 20th century, though it has now evolved into a separate human-only disease. Most strains of influenza that infect humans are human diseases, although many strains of bird flu and swine flu are zoonoses; these viruses occasionally recombine with human strains of the flu and can cause pandemics such as the 1918 Spanish flu or the 2009 swine flu. ''Taenia solium'' infection is one of the neglected tropical diseases with public health and veterinary concern in en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Virus
An RNA virus is a virusother than a retrovirusthat has ribonucleic acid (RNA) as its genetic material. The nucleic acid is usually single-stranded RNA ( ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA viruses include the common cold, influenza, SARS, MERS, Covid-19, Dengue Virus, hepatitis C, hepatitis E, West Nile fever, Ebola virus disease, rabies, polio, mumps, and measles. The International Committee on Taxonomy of Viruses (ICTV) classifies RNA viruses as those that belong to ''Group III'', ''Group IV'' or ''Group V'' of the Baltimore classification system. This category excludes ''Group VI'', viruses with RNA genetic material but which use DNA intermediates in their life cycle: these are called retroviruses, including HIV-1 and HIV-2 which cause AIDS. As of May 2020, all known RNA viruses encoding an RNA-directed RNA polymerase are believed to form a monophyletic group, known as the realm '' Riboviria''. The majority of such RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meadow Vole
The eastern meadow vole (''Microtus pennsylvanicus''), sometimes called the field mouse or meadow mouse, is a North American vole found in eastern Canada and the United States. Its range extends farther south along the Atlantic coast. The western meadow vole, Florida salt marsh vole, and beach vole were formerly considered regional variants or subspecies of M. pennsylvanicus, but have all since been designated as distinct species. The eastern meadow vole is active year-round, usually at night. It also digs burrows, where it stores food for the winter and females give birth to their young. Although these animals tend to live close together, they are aggressive towards one another. This is particularly evident in males during the breeding season. They can cause damage to fruit trees, garden plants, and commercial grain crops. Taxonomy The species was formerly grouped with the western meadow vole (''M. drummondii'') and the Florida salt marsh vole (''M. dukecampbelli'') as a s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microtine
The Arvicolinae are a subfamily of rodents that includes the voles, lemmings, and muskrats. They are most closely related to the other subfamilies in the Cricetidae (comprising the hamsters and New World rats and mice). Some authorities place the subfamily Arvicolinae in the family Muridae along with all other members of the superfamily Muroidea. Some refer to the subfamily as the Microtinae (yielding the adjective "microtine") or rank the taxon as a full family, the Arvicolidae. The Arvicolinae are the most populous group of Rodentia in the Northern Hemisphere. They often are found in fossil occlusions of bones cached by past predators such as owls and other birds of prey. Fossils of this group are often used for biostratigraphic dating of paleontological and archeological sites in North America and Europe. Description The most convenient distinguishing feature of the Arvicolinae is the nature of their molar teeth, which have prismatic cusps in the shape of alternating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cricetid
The Cricetidae are a family (biology), family of rodents in the large and complex superfamily Muroidea. It includes true hamsters, voles, lemmings, Muskrat, muskrats, and New World rats and mice. At almost 608 species, it is the second-largest Family (biology), family of mammals, and has members throughout the Americas, Europe and Asia. Characteristics The cricetids are small mammals, ranging from just in length and in weight in the Baiomys, New World pygmy mouse up to and in the muskrat. The length of their tails varies greatly in relation to their bodies, and they may be either furred or sparsely haired. The fur of most species is brownish in colour, often with a white underbelly, but many other patterns exist, especially in the Cricetinae, cricetine and Arvicolinae, arvicoline subfamilies. Like the Muridae, Old World mice, cricetids are adapted to a wide range of habitats, from the high Arctic to tropical rainforests and hot deserts. Some are arboreal, with long balancin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frederick County, Maryland
Frederick County is located in the northern part of the U.S. state of Maryland. At the 2020 U.S. Census, the population was 271,717. The county seat is Frederick. Frederick County is included in the Washington-Arlington-Alexandria, DC-VA-MD-WV Metropolitan Statistical Area. Like other outlying sections of the Washington metropolitan area, Frederick County has experienced a rapid population increase in recent years. It borders the southern border of Pennsylvania and the northeastern border of Virginia. The county is the location of Catoctin Mountain Park (encompassing the presidential retreat Camp David) and the U.S. Army's Fort Detrick. Etymology The namesake of Frederick County and its county seat is unknown, but it was probably either Frederick, Prince of Wales, or Frederick Calvert, 6th Baron Baltimore. History Frederick County was created in 1748 by the Province of Maryland from parts of Prince George's County and Baltimore County. In 1776, following US independence, F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aerosolization
Aerosolization is the process or act of converting some physical substance into the form of particles small and light enough to be carried on the air i.e. into an aerosol. Aerosolization refers to a process of intentionally oxidatively converting and suspending particles or a composition in a moving stream of air for the purpose of delivering the oxidized particles or composition to a particular location. The term is often used in medicine to refer specifically to the production of airborne particles (e.g. tiny liquid droplets) containing infectious virus or bacteria. The infectious organism is said to be ''aerosolized''. This can occur when an infected individual coughs, sneezes exhales, or vomits, but can also arise from flushing a toilet, or disturbing dried contaminated feces. Treatment of some respiratory diseases relies on aerosolization of a liquid medication using a nebulizer, which is then breathed in for direct transport to the lungs. In the context of chemical and biolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fomite
A fomite () or fomes () is any inanimate object that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host. Transfer of pathogens by fomites A fomite is any inanimate object (also called passive vector) that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host. Contamination can occur when one of these objects comes into contact with bodily secretions, like nasal fluid, vomit, or feces. Many common objects can sustain a pathogen until a person comes in contact with the pathogen, increasing the chance of infection. The likely objects are different in a hospital environment than at home or in a workplace. Fomites such as splinters, barbed wire or farmyard surfaces, including soil, feeding troughs or barn beams, have been implicated as sources of virus. Hospital fomites For humans, common hospital fomites are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isla Vista Virus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses. Orthohantaviruses typically cause chronic asymptomatic infection in rodents. Humans may become infected with hantaviruses through contact with rodent urine, saliva, or feces. Some strains cause potentially fatal diseases in humans, such as hantavirus hemorrhagic fever with renal syndrome (HFRS), or hantavirus pulmonary syndrome (HPS), also known as hantavirus cardiopulmonary syndrome (HCPS), while others have not been associated with known human disease (e.g. Prospect Hill virus). HPS (HCPS) is a "rare respiratory illness associated with the inhalation of aerosolized rodent excreta (urine and feces) contaminated by hantavirus particles." Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement; however, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hantaan River Virus
''Hantaan orthohantavirus'' (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World ''Orthohantavirus''. It is the causative agent of Korean hemorrhagic fever in humans. It is named for the Hantan River in South Korea, and in turn lends the name to its genus ''Orthohantavirus'' and family ''Hantaviridae''. Natural reservoir '' Apodemus agrarius'', also known as striped field mouse, is the etiological vector of ''Hantaan orthohantavirus''. Transmission Transmission is believed to be through inhalation of aerosolized rodent urine and feces. Morbidity and mortality In hantavirus induced hemorrhagic fever, incubation time is between two and four weeks in humans before symptoms of infection present. Severity of symptoms depends on the viral load. Like Dobrava-Belgrade virus, Hantaan virus has a mortality rate of 10 to 12%. History During the Korean War (1951–1953), more than 3000 American and Korean troops fell ill with kidney failure, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
