''Prospect Hill orthohantavirus'' is a single-stranded,
negative-sense
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, ...
Hantaan-like
zoonotic
A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. ...
RNA virus
An RNA virus is a virusother than a retrovirusthat has ribonucleic acid (RNA) as its genetic material. The nucleic acid is usually single-stranded RNA ( ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA viruses ...
isolated from
meadow vole
The eastern meadow vole (''Microtus pennsylvanicus''), sometimes called the field mouse or meadow mouse, is a North American vole found in eastern Canada and the United States. Its range extends farther south along the Atlantic coast.
The weste ...
s and
microtine and other
cricetid
The Cricetidae are a family (biology), family of rodents in the large and complex superfamily Muroidea. It includes true hamsters, voles, lemmings, Muskrat, muskrats, and New World rats and mice. At almost 608 species, it is the second-largest Fa ...
rodents in the United States.
[ It has a widespread distribution in Pennsylvania, Maryland, West Virginia, Minnesota and California. The overall risk of infection in humans is low. It was first isolated from a meadow vole found in Prospect Hill, Maryland for which it is named.][Yanagihara R, Daum CA, Lee PW, Baek LJ, Amyx HL, Gajdusek DC, Gibbs CJ Jr.Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA.Trans R Soc Trop Med Hyg. 1987;81(1):42–5.]
Transmission
Transmission to humans is believed to occur through aerosolized inhalation of mouse excreta and possibly through fomite
A fomite () or fomes () is any inanimate object that, when contaminated with or exposed to infectious agents (such as pathogenic bacteria, viruses or fungi), can transfer disease to a new host.
Transfer of pathogens by fomites
A fomite is any ina ...
contamination.
See also
* Isla Vista virus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Orthohantav ...
* Hantaan River virus
''Hantaan orthohantavirus'' (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World ''Orthohantavirus''. It is the causative agent of Korean hemorrhagic fever in humans. It is named for the Hantan River in South ...
* Bloodland Lake virus
References
External links
Sloan Science and Film / Short Films / Muerto Canyon
by Jen Peel 29 minutes
by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
{{Taxonbar, from=Q29002552
Viral diseases
Hantaviridae
Rodent-carried diseases