|
Prontosil
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist. The discovery and development of this first sulfonamide drug opened a new era in medicine, because it greatly widened the success of antimicrobial chemotherapy in an era when many physicians doubted its still largely untapped potential. At the time, disinfectant cleaners and topical antiseptic wound care were widely used but there were very few antimicrobial drugs to use safely inside living bodies. Antibiotic drugs derived from microbes, which we rely on heavily today, did not yet exist. Prontosil was discovered in 1932 by a research team at the Bayer Laboratories of the IG Farben conglomerate in Germany. Names The capitalized name "Prontosil" is Bayer's trade name; the nonproprietary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerhard Domagk
Gerhard Johannes Paul Domagk (; 30 October 1895 – 24 April 1964) was a German pathologist and bacteriologist. He is credited with the discovery of sulfonamidochrysoidine (KL730) as an antibiotic for which he received the 1939 Nobel Prize in Physiology or Medicine. The drug became the first commercially available antibiotic and marketed under the brand name Prontosil. While working in the pathology department of the University of Münster, Domagk was invited to join the IG Farben branch at Elberfeld (later Wuppertal) in 1927. His duty was to test chemical compounds prepared at the IG Farben laboratory for potential drugs. A novel compound synthesised by Friedrich Mietzsch and Joseph Klarer, a benzene derivative of azo dye attached with sulphonamide group as a side chain was found to have antibacterial activity against human bacterium ''Streptococcus pyogenes.'' In 1935, Domagk's only daughter, Hildegarde, injured herself and contracted a streptococcal infection. In a desperate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DHP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Colebrook
Leonard Colebrook FRS ( – ) was an English physician and bacteriologist. Education Colebrook was educated at the Grammar School in Guildford (1891–96), Westbourne High School in Bournemouth (1896–99) and Christ's College Blackheath in Kent (1899 - 1900). Colebrook started his medical training at the London Hospital Medical College after which he won a scholarship to St Mary's Hospital, London, graduating in 1906 with M.B. and B.S. (Lond). degrees. Career He stayed at St Mary's Hospital Medical School from 1907 - 14. he was initially appointed as an assistant to Sir Almroth Wright in the inoculation Department. He worked on vaccine therapy, tuberculosis and pneumonia. At the outbreak of the First World War he was appointed as a captain in the Royal Army Medical Corps and the Battalion Medical Officer of the Kensington Regiment. He stayed initially at St Mary's Hospital but in 1917 was transferred to France where he worked on wound infections with Sir Almroth Wright at No ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Puerperal Fever
Postpartum infections, also known as childbed fever and puerperal fever, are any bacterial infections of the female reproductive tract following childbirth or miscarriage. Signs and symptoms usually include a fever greater than , chills, lower abdominal pain, and possibly bad-smelling vaginal discharge. It usually occurs after the first 24 hours and within the first ten days following delivery. The most common infection is that of the uterus and surrounding tissues known as puerperal sepsis, postpartum metritis, or postpartum endometritis. Risk factors include Caesarean section (C-section), the presence of certain bacteria such as group B streptococcus in the vagina, premature rupture of membranes, multiple vaginal exams, manual removal of the placenta, and prolonged labour among others. Most infections involve a number of types of bacteria. Diagnosis is rarely helped by culturing of the vagina or blood. In those who do not improve, medical imaging may be required. Other causes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Dye
Azo dyes are organic compounds bearing the functional group R−N=N−R′, in which R and R′ are usually aryl and substituted aryl groups. They are a commercially important family of azo compounds, i.e. compounds containing the C-N=N-C linkage. Azo dyes are synthetic dyes and do not occur naturally. Most azo dyes contain only one azo group, but some dyes called "disazo dyes" contain two azo groups, some dyes called "trisazo dyes" contain three azo groups and are or more. Azo dyes comprise 60-70% of all dyes used in food and textile industries. Azo dyes are widely used to treat textiles, leather articles, and some foods. Chemically related derivatives of azo dyes include azo pigments, which are insoluble in water and other solvents. Classes Many kinds of azo dyes are known, and several classification systems exist. Some classes include disperse dyes, metal-complex dyes, reactive dyes, and substantive dyes. Also called direct dyes, substantive dyes are employed for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tube Of Prontosil Tablets, Germany, 1935-1950 Wellcome L0057805
Tube or tubes may refer to: * ''Tube'' (2003 film), a 2003 Korean film * ''The Tube'' (TV series), a music related TV series by Channel 4 in the United Kingdom * "Tubes" (Peter Dale), performer on the Soccer AM television show * Tube (band), a Japanese rock band * Tube & Berger, the alias of dance/electronica producers Arndt Rörig and Marco Vidovic from Germany * The Tube Music Network, a music video network that operated between 2006 and 2007 * The Tubes, a San Francisco-based band, popular in the 1970s and 1980s Other media * Tube, a freeware game for MS-DOS computers from Bullfrog Productions * ''TUBE.'', an online magazine about visual and performing arts, founded in 2012 in Sacramento, California * Series of tubes, an analogy for the Internet used by United States Senator Ted Stevens * Picture tube, term in Paint Shop Pro software for a small digital image with no background * YouTube, a video sharing website Science, technology, and mathematics Construction and mechanic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franklin D
Franklin may refer to: People * Franklin (given name) * Franklin (surname) * Franklin (class), a member of a historical English social class Places Australia * Franklin, Tasmania, a township * Division of Franklin, federal electoral division in Tasmania * Division of Franklin (state), state electoral division in Tasmania * Franklin, Australian Capital Territory, a suburb in the Canberra district of Gungahlin * Franklin River, river of Tasmania * Franklin Sound, waterway of Tasmania Canada * District of Franklin, a former district of the Northwest Territories * Franklin, Quebec, a municipality in the Montérégie region * Rural Municipality of Franklin, Manitoba * Franklin, Manitoba, an unincorporated community in the Rural Municipality of Rosedale, Manitoba * Franklin Glacier Complex, a volcano in southwestern British Columbia * Franklin Range, a mountain range on Vancouver Island, British Columbia * Franklin River (Vancouver Island), British Columbia * Franklin Strai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TIME Magazine
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United States. The two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franklin Delano Roosevelt, Jr
Franklin may refer to: People * Franklin (given name) * Franklin (surname) * Franklin (class), a member of a historical English social class Places Australia * Franklin, Tasmania, a township * Division of Franklin, federal electoral division in Tasmania * Division of Franklin (state), state electoral division in Tasmania * Franklin, Australian Capital Territory, a suburb in the Canberra district of Gungahlin * Franklin River, river of Tasmania * Franklin Sound, waterway of Tasmania Canada * District of Franklin, a former district of the Northwest Territories * Franklin, Quebec, a municipality in the Montérégie region * Rural Municipality of Franklin, Manitoba * Franklin, Manitoba, an unincorporated community in the Rural Municipality of Rosedale, Manitoba * Franklin Glacier Complex, a volcano in southwestern British Columbia * Franklin Range, a mountain range on Vancouver Island, British Columbia * Franklin River (Vancouver Island), British Columbia * Franklin Strait ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Düsseldorf University Hospital
Düsseldorf ( , , ; often in English sources; Low Franconian and Ripuarian: ''Düsseldörp'' ; archaic nl, Dusseldorp ) is the capital city of North Rhine-Westphalia, the most populous state of Germany. It is the second-largest city in the state and the seventh-largest city in Germany, with a population of 617,280. Düsseldorf is located at the confluence of two rivers: the Rhine and the Düssel, a small tributary. The ''-dorf'' suffix means "village" in German (English cognate: ''thorp''); its use is unusual for a settlement as large as Düsseldorf. Most of the city lies on the right bank of the Rhine. Düsseldorf lies in the centre of both the Rhine-Ruhr and the Rhineland Metropolitan Region. It neighbours the Cologne Bonn Region to the south and the Ruhr to the north. It is the largest city in the German Low Franconian dialect area (closely related to Dutch). Mercer's 2012 Quality of Living survey ranked Düsseldorf the sixth most livable city in the world. Düsseldo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wuppertal
Wuppertal (; "''Wupper Dale''") is, with a population of approximately 355,000, the seventh-largest city in North Rhine-Westphalia as well as the 17th-largest city of Germany. It was founded in 1929 by the merger of the cities and towns of Elberfeld, Barmen, Ronsdorf, Cronenberg and Vohwinkel, and was initially "Barmen-Elberfeld" before adopting its present name in 1930. It is regarded as the capital and largest city of the Bergisches Land (historically this was Düsseldorf). The city straddles the densely populated banks of the River Wupper, a tributary of the Rhine called ''Wipper'' in its upper course. Wuppertal is located between the Ruhr (Essen) to the north, Düsseldorf to the west, and Cologne to the southwest, and over time has grown together with Solingen, Remscheid and Hagen. The stretching of the city in a long band along the narrow Wupper Valley leads to a spatial impression of Wuppertal being larger than it actually is. The city is known for its steep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
