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Philippe Sansonetti
Philippe J. Sansonetti (born 9 April 1949) is a French microbiologist, professor at the Pasteur Institute and the Collège de France in Paris. He is the director of the Inserm Unit 786 (Microbial colonisation and invasion of mucosa) and of the Institut Pasteur laboratory Pathogénie Microbienne Moléculaire. Education Philippe Sansonetti completed General Microbiology, General Virology and Immunology courses at the Institut Pasteur and received his MS degree in Biochemistry/Microbiology from the University Paris VII Diderot in 1978 and obtained his MD degree from the University Paris VI in 1979. After a research fellowship at the Unité de Bactériologie Médicale headed by Léon Le Minor, he undertook a post-doctoral position in the laboratory of Professor Samuel Formal in the Department of Enteric Diseases at the Walter Reed Army Institute of Research, Washington, D.C. He returned to the Pasteur Institute in 1981 to the Enterobacteria Unit (Unité des entérobactéries) wher ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paris Diderot University
Paris Diderot University, also known as Paris 7 (french: Université Paris Diderot), was a French university located in Paris, France. It was one of the inheritors of the historic University of Paris, which was split into 13 universities in 1970. Paris Diderot merged with Paris Descartes University in 2019 to form Paris Cité University. With two Nobel Prize laureates, two Fields Medal winners and two former French Ministers of Education among its faculty or former faculty, the university was famous for its teaching in science, especially in mathematics. Many fundamental results of the theory of probability were discovered at one of its research centres, the ''Laboratoire de Probabilités et Modèles Aléatoires'' (Laboratory of Probability and Random Models). History Paris Diderot University was one of the heirs of the old University of Paris, which ceased to exist in 1970. Professors from the faculties of Science, of Medicine and of Humanities chose then to create a new mul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dysentery
Dysentery (UK pronunciation: , US: ), historically known as the bloody flux, is a type of gastroenteritis that results in bloody diarrhea. Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. Complications may include dehydration. The cause of dysentery is usually the bacteria from genus ''Shigella'', in which case it is known as shigellosis, or the amoeba '' Entamoeba histolytica''; then it is called amoebiasis. Other causes may include certain chemicals, other bacteria, other protozoa, or parasitic worms. It may spread between people. Risk factors include contamination of food and water with feces due to poor sanitation. The underlying mechanism involves inflammation of the intestine, especially of the colon. Efforts to prevent dysentery include hand washing and food safety measures while traveling in areas of high risk. While the condition generally resolves on its own within a week, drinking sufficient fluids such as oral reh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Légion D'honneur
The National Order of the Legion of Honour (french: Ordre national de la Légion d'honneur), formerly the Royal Order of the Legion of Honour ('), is the highest French order of merit, both military and civil. Established in 1802 by Napoleon Bonaparte, it has been retained (with occasional slight alterations) by all later French governments and regimes. The order's motto is ' ("Honour and Fatherland"); its seat is the Palais de la Légion d'Honneur next to the Musée d'Orsay, on the left bank of the Seine in Paris. The order is divided into five degrees of increasing distinction: ' (Knight), ' (Officer), ' ( Commander), ' (Grand Officer) and ' (Grand Cross). History Consulate During the French Revolution, all of the French orders of chivalry were abolished and replaced with Weapons of Honour. It was the wish of Napoleon Bonaparte, the First Consul, to create a reward to commend civilians and soldiers. From this wish was instituted a , a body of men that was not an or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FEMS
Federation of European Microbiological Societies (FEMS) is an international European scientific organization, formed by the union of a number of national organizations; there are now 57 members from 41 European countries, regular and provisional. Members can apply for fellowships, grants and/or support when organising a meeting. FEMS facilitates exchange of scientific knowledge to all microbiologists in Europe and worldwide by publishing seven microbiology journals and organising a biennial congress for microbiologists around the world. It also initiates campaigns such as the European Academy of Microbiology (EAM). Since 1977, it has been the sponsor of ''FEMS Microbiology Letters'', a single journal. Now, FEMS publishes seven journals: * ''FEMS Microbiology Ecology'' * ''FEMS Microbiology Reviews'' * ''FEMS Microbiology Letters'' * ''FEMS Yeast Research'' * ''Pathogens and Disease'' a journal preceded by ''FEMS Immunology and Medical Microbiology'' * ''FEMS Microbes'' * ''FEMS mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Koch Prize
The Robert Koch Medal and Award are two prizes awarded annually by the German for excellence in the biomedical sciences. These awards grew out of early attempts by German physician Robert Koch to generate funding to support his research into the cause and cure for tuberculosis. Koch discovered the bacteria ('' Mycobacterium tuberculosis'') responsible for the dreaded disease and rapidly acquired international support, including 500,000 gold marks from the Scottish-American philanthropist Andrew Carnegie. The Robert Koch Prize Since 1970, the Robert Koch Foundation has awarded prizes for major advances in the biomedical sciences, particularly in the fields of microbiology and immunology. The prestige of this award has grown over the past decades so that it is now widely regarded as the leading international scientific prize in microbiology. As has been described by a jury member for the prize, the committee often asks, "What would Robert Koch work on today?” to decide on res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cellular Microbiology
Cellular microbiology is a discipline that bridges microbiology and cell biology. The term "cellular microbiology" was coined by the authors of the book of the same title published in 1996. Cooperation and mutual dependency between microbiology and cell biology had been increasing in the years before that, and the emergence of a new discipline had been suggested and discussed in several scientific conferences. Cellular microbiology attempts to use pathogenic microorganisms as tools for cell-biology research, and to employ cell-biology methods to understand the pathogenicity of microorganisms. Toxins and virulence factors from microbes have been used for decades to influence processes in eukaryotic cells and to study them. It has increasingly appeared that applying a purified toxin on a cell does not always provide the complete picture, and that understanding the role of the toxin in pathogenicity, the way the toxin promotes the microbe, the way the toxin is produced and the co- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adaptive Immune Response
The adaptive immune system, also known as the acquired immune system, is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens. Unlike the innate immune system, which is pre-programmed to react to common broad categories of pathogen, the adaptive immune system is highly specific to each particular pathogen the body has encountered. Adaptive immunity creates immunological memory after an initial response to a specific pathogen, and leads to an enhanced response to future encounters with that pathogen. Antibodies are a critical part of the adaptive immune system. Adaptive immunity can provide long ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Innate Immune Response
The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).. The major functions of the innate immune system are to: * recruit immune cells to infection sites by producing chemical factors, including chemical mediators called cytokines * activate the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells * identify and remove foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells * activate the adaptive immune system through antigen presentation * act as a physical and chemical barrier to infectious agents; via physical measures such as skin and chemical measures such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pro-inflammatory Cytokine
An inflammatory cytokine or proinflammatory cytokine is a type of signaling molecule (a cytokine) that is secreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation. They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory cytokines are predominantly produced by and involved in the upregulation of inflammatory reactions. Excessive chronic production of inflammatory cytokines contribute to inflammatory diseases, that have been linked to different diseases, such as atherosclerosis and cancer. Dysregulation has also been linked to depression and other neurological diseases. A balance between proinflammatory and anti-inflammatory cytokines is necessary to maintain health. Aging and exercise also play a role ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyroptosis
Pyroptosis is a highly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis can take place in immune cells and is also reported to occur in keratinocytes and some epithelial cells. The process is initiated by formation of a large supramolecular complex termed the inflammasome (also known as a pyroptosome) upon intracellular danger signals. The inflammasome activates a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation and activation of several proinflammatory cytokines and pore-forming protein gasdermins. Formation of pores causes cell membrane ruptur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrophage
Macrophages (abbreviated as M φ, MΦ or MP) ( el, large eaters, from Greek ''μακρός'' (') = large, ''φαγεῖν'' (') = to eat) are a type of white blood cell of the immune system that engulfs and digests pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. The process is called phagocytosis, which acts to defend the host against infection and injury. These large phagocytes are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense ( innate immunity) and also help initiate specific defense mechanisms (adaptive immunity) by recruiting othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
