Philippe Gaucher
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Philippe Gaucher
Philippe Charles Ernest Gaucher () (July 26, 1854 – January 25, 1918) was a French dermatologist born in the department of Nièvre. He received his medical doctorate in 1882, and soon after headed a medical clinic at Necker Hospital. During the subsequent years he was an instructor at several hospital clinics in Paris. He taught classes on pathological anatomy, bacteriology and histology, as well as dermatology. In 1902 he succeeded Jean Alfred Fournier (1832–1914) as the university chair of dermatology and syphilography. Gaucher was also founder of a journal on venereal disease called ''Annales des Maladies Vénériennes''. He is remembered for providing a description of a disorder that was to become known as Gaucher's disease. In 1882 while still a student, he discovered the disease in a 32-year-old woman who had an enlarged spleen. At the time, Gaucher thought it to be a form of splenetic cancer, and published his findings in his doctorate thesis, titled ''De l'epithelioma ...
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Philippe Charles Ernest GAUCHER
Philippe is a masculine sometimes feminin given name, cognate to Philip. It may refer to: * Philippe of Belgium (born 1960), King of the Belgians (2013–present) * Philippe (footballer) (born 2000), Brazilian footballer * Prince Philippe, Count of Flanders, father to Albert I of Belgium * Philippe d'Orléans (other), multiple people * Philippe A. Autexier (1954–1998), French music historian * Philippe Blain, French volleyball player and coach * Philippe Najib Boulos (1902–1979), Lebanese lawyer and politician * Philippe Coutinho, Brazilian footballer * Philippe Daverio (1949–2020), Italian art historian * Philippe Dubuisson-Lebon, Canadian football player * Philippe Ginestet (born 1954), French billionaire businessman, founder of GiFi * Philippe Gilbert, Belgian bicycle racer * Philippe Petit, French performer and tightrope artist * Philippe Petitcolin (born 1952/53), French businessman, CEO of Safran * Philippe Russo, French singer * Philippe Sella, French rugby pla ...
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Syphilis
Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary). The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration usually between 1 cm and 2 cm in diameter) though there may be multiple sores. In secondary syphilis, a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. In latent syphilis, which can last for years, there are few or no symptoms. In tertiary syphilis, there are gummas (soft, non-cancerous growths), neurological problems, or heart symptoms. Syphilis has been known as "the great imitator" as it may cause symptoms similar to many other diseases. Syphilis is most commonly spread through sexual activity. It may also be transmi ...
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1918 Deaths
This year is noted for the end of the World War I, First World War, on the eleventh hour of the eleventh day of the eleventh month, as well as for the Spanish flu pandemic that killed 50–100 million people worldwide. Events Below, the events of World War I have the "WWI" prefix. January * January – 1918 flu pandemic: The "Spanish flu" (influenza) is first observed in Haskell County, Kansas. * January 4 – The Finnish Declaration of Independence is recognized by Russian Soviet Federative Socialist Republic, Soviet Russia, Sweden, German Empire, Germany and France. * January 9 – Battle of Bear Valley: U.S. troops engage Yaqui people, Yaqui Native American warriors in a minor skirmish in Arizona, and one of the last battles of the American Indian Wars between the United States and Native Americans. * January 15 ** The keel of is laid in Britain, the first purpose-designed aircraft carrier to be laid down. ** The Red Army (The Workers and Peasants Red Army) ...
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1854 Births
Events January–March * January 4 – The McDonald Islands are discovered by Captain William McDonald aboard the ''Samarang''. * January 6 – The fictional detective Sherlock Holmes is perhaps born. * January 9 – The Teutonia Männerchor in Pittsburgh, U.S.A. is founded to promote German culture. * January 20 – The North Carolina General Assembly in the United States charters the Atlantic and North Carolina Railroad, to run from Goldsboro through New Bern, to the newly created seaport of Morehead City, near Beaufort. * January 21 – The iron clipper runs aground off the east coast of Ireland, on her maiden voyage out of Liverpool, bound for Australia, with the loss of at least 300 out of 650 on board. * February 11 – Major streets are lit by coal gas for the first time by the San Francisco Gas Company; 86 such lamps are turned on this evening in San Francisco, California. * February 13 – Mexican troops force William Wa ...
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Biochemical
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis which allows biological molecules to give rise to the processes that occur within living cells and between cells,Karp (2009), p. 2. in turn relating greatly to the understanding of tissues and organs, as well as organism structure and function.Miller (2012). p. 62. Biochemistry is closely related to molecular biology, which is the study of the molecular mechanisms of biological phenomena.A ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ...
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Spleen
The spleen is an organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter. The word spleen comes .σπλήν
Henry George Liddell, Robert Scott, ''A Greek-English Lexicon'', on Perseus Digital Library
The spleen plays very important roles in regard to s (erythrocytes) and the . It removes old red blood cells and holds a reserve of blood, which can be valuable in case of

Gaucher's Disease
Gaucher's disease or Gaucher disease () (GD) is a genetic disorder A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders ... in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs. The disorder is characterized by bruising, fatigue (medical), fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the enzyme glucocerebrosidase (also known as glucosylceramidase), which acts on glucocerebroside. When the enzyme is defective, glucocerebroside accumulates, particularly in white blood cells and especially in macrophages (mononuclear leukocytes, which is often a target for intracellular parasites). Glucocerebroside can collect in the spleen, liver, kidneys, Human lung, ...
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Venereal Disease
Sexually transmitted infections (STIs), also referred to as sexually transmitted diseases (STDs) and the older term venereal diseases, are infections that are spread by sexual activity, especially vaginal intercourse, anal sex, and oral sex. STIs often do not initially cause symptoms, which results in a risk of passing the infection on to others. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility. Bacterial STIs include chlamydia, gonorrhea, and syphilis. Viral STIs include genital herpes, HIV/AIDS, and genital warts. Parasitic STIs include trichomoniasis. STI diagnostic tests are usually easily available in the developed world, but they are often unavailable in the developing world. Some vaccinations may also decrease the risk of certain infections including hepatitis B and some types of HPV. Safe sex practices, such as use of condoms, having a smaller number ...
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Jean Alfred Fournier
Jean Alfred Fournier () (21 May 1832 – 25 December 1914) was a French dermatologist who specialized in the study of venereal disease. Biography As a young man he served as an interne at the Hôpital du Midi as an understudy to Philippe Ricord (1800–1889). In 1863 he became ''médecine des hôpitaux'', and from 1867 worked with Augustin Grisolle (1811–1869) at the Hôtel-Dieu de Paris. In 1876 he was appointed ''chef de service'' at the Hôpital Saint-Louis, later becoming a member of the ''Académie de Médecine'' (1880). His main contribution to medical science was the study of congenital syphilis, of which he provided a description of in 1883. In his numerous publications he stressed the importance of syphilis being the cause of degenerative diseases. In addition, in 1901 he founded an organization devoted to spreading knowledge to combat syphilis, called the ''Société Française de Prophylaxie Sanitaire et Morale''. His name is associated with the following three ...
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Dermatologist
Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical doctor who manages diseases related to skin, hair, nails, and some cosmetic problems. Etymology Attested in English in 1819, the word "dermatology" derives from the Greek δέρματος (''dermatos''), genitive of δέρμα (''derma''), "skin" (itself from δέρω ''dero'', "to flay") and -λογία '' -logia''. Neo-Latin ''dermatologia'' was coined in 1630, an anatomical term with various French and German uses attested from the 1730s. History In 1708, the first great school of dermatology became a reality at the famous Hôpital Saint-Louis in Paris, and the first textbooks (Willan's, 1798–1808) and atlases ( Alibert's, 1806–1816) appeared in print around the same time.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in ...
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Dermatology
Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical doctor who manages diseases related to skin, hair, nails, and some cosmetic problems. Etymology Attested in English in 1819, the word "dermatology" derives from the Greek δέρματος (''dermatos''), genitive of δέρμα (''derma''), "skin" (itself from δέρω ''dero'', "to flay") and -λογία '' -logia''. Neo-Latin ''dermatologia'' was coined in 1630, an anatomical term with various French and German uses attested from the 1730s. History In 1708, the first great school of dermatology became a reality at the famous Hôpital Saint-Louis in Paris, and the first textbooks (Willan's, 1798–1808) and atlases ( Alibert's, 1806–1816) appeared in print around the same time.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in ...
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