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Pestalotiopsis Microspora
''Pestalotiopsis microspora'' is a species of endophytic fungus capable of breaking down and digesting polyurethane. Originally identified in 1880 in fallen foliage of common ivy ('' Hedera helix'') in Buenos Aires, it also causes leaf spot in Hypericum 'Hidcote' ('' Hypericum patulum'') shrubs in Japan. However, its polyurethane degradation activity was discovered only in the 2010s in two distinct ''P. microspora'' strains isolated from plant stems in the Yasuni National Forest within the Ecuadorian Amazon rainforest by a group of student researchers led by molecular biochemistry professor Scott Strobel as part of Yale's annual Rainforest Expedition and Laboratory. It is the first fungus species found to be able to subsist on polyurethane in anaerobic conditions. This makes the fungus a potential candidate for bioremediation projects involving large quantities of plastic. ''Pestalotiopsis microspora'' was originally described from Buenos Aires, Argentina in 1880 by mycolo ...
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Carlo Luigi Spegazzini
Carlo Luigi Spegazzini, in Spanish Carlos Luis Spegazzini (20 April 1858 – 1 July 1926), was an Italian-born Argentinian botanist and mycologist. On the 1881/1882 expedition led by Giacomo Bove to explore Patagonia and Tierra del Fuego, the Italian Decio Vinciguerra was officially both zoologist and botanist, but in fact Spegazzini handled the botanical work. Spegazzini published about 100 scientific papers on vascular plants, describing around 1000 new taxa. He was a professor at the University of La Plata and Buenos Aires in Argentina, curator of the herbarium of the National Department of Agriculture, first head of the herbarium of Museo de la Plata, and founder of an arboretum and an institute of mycology in La Plata city. In 1924 he edited the journal ''Revista Argentina de Botánica'', but only four issues were published before his death. In a 1924 ''Mycologia'' publication, William Murrill recounted his time visiting with Spegazzini, who was then 66 years old: Dr Spe ...
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Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregationalism in the United States, Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first Doctor of Philosophy, PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and sc ...
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Aspergillus Tubingensis
''Aspergillus tubingensis'' is a darkly pigmented species of fungus in the genus ''Aspergillus'' section Nigri. It is often confused with ''Aspergillus niger'' due to their similar morphology and habitat. ''A. tubingensis'' is often involved in food spoilage of fruits and wheat, and industrial fermentation. This species is a rare agent of opportunistic infection. Background ''Aspergillus tubingensis'' was first discovered by Raoul Mosseray in 1934. The conidia are heavily roughened, 3-5 µm in diameter. Whitish to pink sclerotia ranging from 0.5-0.8 mm in diameter are often produced. ''A. tubingensis'' exists exclusively as an asexual fungus but is understood to be phylogenetically closely related to the other so-called black Aspergilli and sexual states in the genus '' Petromyces''. The production of Ochratoxin A (OTA) was previously thought to be a variable character dependent on strain; however, the production of OTA is thought to be a consistent feature with prio ...
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Taxus Brevifolia
''Taxus brevifolia'', the Pacific yew or western yew, is a species of tree in the yew family Taxaceae native to the Pacific Northwest of North America. It is a small evergreen conifer, thriving in moisture and otherwise tending to take the form of a shrub. Description A small evergreen conifer (sometimes appearing as a shrub), the Pacific yew grows to tall and with a trunk up to diameter, rarely more. In some instances, trees with heights in excess of occur in parks and other protected areas, quite often in gullies. The tree is extremely slow growing, and has a habit of rotting from the inside, creating hollow forms. This makes it difficult and sometimes impossible to make accurate ring counts to determine a specimen's true age. Often damaged by succession of the forest, it usually ends up in a squat, multiple-leader form, able to grow new sprouts from decapitated stumps. In its shrub form, sometimes called "yew brush", it can reproduce vegetatively via layering. It has thi ...
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Paclitaxel
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation. Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division. Paclitaxel was first isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made from ...
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Torreya Taxifolia
''Torreya taxifolia'', commonly known as Florida torreya or stinking-cedar, but also sometimes as Florida nutmeg or gopher wood, is an endangered subcanopy tree of the yew family, Taxaceae. It is native to only a small glacial refugium in the southeastern United States, at the state border region of northern Florida and southwestern Georgia. Species discovery In 1821 colonial control of the Florida Territory shifted from Spain to the United States. Plantation owners and their slaves began to move into the territory, exacerbating conflicts with the native peoples and the existing population of runaway slaves. One such plantation owner was the patriarch of the Croom family, who in 1826 purchased land around the town of Tallahassee. When he died in 1829, his two sons inherited and invested further in the region, buying up or leasing other plantations. One of the two sons was Hardy Bryan Croom. Croom had studied law and became a state senator in North Carolina in his early thirti ...
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Quinone
The quinones are a class of organic compounds that are formally "derived from aromatic compounds uch as benzene or naphthalene">benzene.html" ;"title="uch as benzene">uch as benzene or naphthalene] by conversion of an even number of –CH= groups into –C(=O)– groups with any necessary rearrangement of double bonds, resulting in "a fully Conjugated system, conjugated cyclic diketone, dione structure". The archetypical member of the class is 1,4-benzoquinone or cyclohexadienedione, often called simply "quinone" (thus the name of the class). Other important examples are 1,2-benzoquinone (''ortho''-quinone), 1,4-naphthoquinone and 9,10-anthraquinone. The name is derived from that of quinic acid (with the suffix "-one" indicating a ketone), since it is one of the compounds obtained upon oxidation of quinic acid. Quinic acid, like quinine is obtained from cinchona bark, called quinaquina in the indigenous languages of Peruvian tribes. Properties Quinones are oxidized derivativ ...
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Torreyanic Acid
Torreyanic acid is a dimeric quinone first isolated and by Lee ''et al.'' in 1996 from an endophyte, ''Pestalotiopsis microspora''. This endophyte is likely the cause of the decline of Florida torreya (''Torreya taxifolia''), an endangered species that is related to the taxol-producing ''Taxus brevifolia''. The natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 µg/mL, ranging from 3.5 (NEC) to 45 (A549) µg/mL. Torreyanic acid was found to be 5-10 times more potent in cell lines sensitive to protein kinase C (PKC) agonists, 12-o-tetradecanoyl phorbol-13-acetate (TPA), and was shown to cause cell death via apoptosis. Torreyanic acid also promoted G1 arrest of G0 synchronized cells at 1-5 µg/mL levels, depending on the cell line. It has been proposed that the eukaryotic translation initiation factor EIF-4a is a potential biochemical target for the natural compound. Biosynthesis There are over 150 na ...
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Julie C
Julie may refer to: * Julie (given name), a list of people and fictional characters with the name Film and television * ''Julie'' (1956 film), an American film noir starring Doris Day * ''Julie'' (1975 film), a Hindi film by K. S. Sethumadhavan featuring Lakshmi * ''Julie'' (1998 film), a British public information film about seatbelt use * ''Julie'' (2004 film), a Hindi film starring Neha Dhupia * ''Julie'' (2006 film), a Kannada film starring Ramya * ''Julie'' (TV series), a 1992 American sitcom starring Julie Andrews Literature * '' Julie; or, The New Heloise'', a 1761 novel by Jean-Jacques Rousseau * ''Julie'' (George novel), a 1994 novel, the second book of a trilogy, by Jean Craighead George * ''Julie'', a 1985 novel by Cora Taylor Music * ''Julie'' (opera), a 2005 opera by Philippe Boesmans Albums * ''Julie'' (album), by Julie London, 1957 * ''Julie'' (EP) or the title song, by Jens Lekman, 2004 Songs * "Julie", by Doris Day, 1956 * "Julie" (Daniel song), by ...
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Species Description
A species description is a formal description of a newly discovered species, usually in the form of a scientific paper. Its purpose is to give a clear description of a new species of organism and explain how it differs from species that have been described previously or are related. In order for species to be validly described, they need to follow guidelines established over time. Zoological naming requires adherence to the ICZN code, plants, the ICN, viruses ICTV, and so on. The species description often contains photographs or other illustrations of type material along with a note on where they are deposited. The publication in which the species is described gives the new species a formal scientific name. Some 1.9 million species have been identified and described, out of some 8.7 million that may actually exist. Millions more have become extinct throughout the existence of life on Earth. Naming process A name of a new species becomes valid (available in z ...
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Newsweek
''Newsweek'' is an American weekly online news magazine co-owned 50 percent each by Dev Pragad, its president and CEO, and Johnathan Davis, who has no operational role at ''Newsweek''. Founded as a weekly print magazine in 1933, it was widely distributed during the 20th century, and had many notable editors-in-chief. The magazine was acquired by The Washington Post Company in 1961, and remained under its ownership until 2010. Revenue declines prompted The Washington Post Company to sell it, in August 2010, to the audio pioneer Sidney Harman for a purchase price of one dollar and an assumption of the magazine's liabilities. Later that year, ''Newsweek'' merged with the news and opinion website ''The Daily Beast'', forming The Newsweek Daily Beast Company. ''Newsweek'' was jointly owned by the estate of Harman and the diversified American media and Internet company IAC. ''Newsweek'' continued to experience financial difficulties, which led to the cessation of print publication ...
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