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Pederin
Pederin is a vesicant toxic amide with two tetrahydropyran rings, found in the haemolymph of the beetle genus ''Paederus'', including the Nairobi fly, belonging to the family Staphylinidae. It was first characterized by processing 25 million field-collected ''P. fuscipes''.Bugs Don’t Have to Bite to Do Damage:The Tale of the Paederus Beetle It makes up approximately 0.025% of an insects weight (for ''P. fuscipes''). It has been demonstrated that the production of pederin relies on the activities of an ('' |
Pederin Synthesis
Pederin is a vesicant toxic amide with two tetrahydropyran rings, found in the haemolymph of the beetle genus ''Paederus'', including the Nairobi fly, belonging to the family Staphylinidae. It was first characterized by processing 25 million field-collected ''P. fuscipes''.Bugs Don’t Have to Bite to Do Damage:The Tale of the Paederus Beetle It makes up approximately 0.025% of an insects weight (for ''P. fuscipes''). It has been demonstrated that the production of pederin relies on the activities of an ('' |
Paederus
''Paederus'' is a genus of small beetles of the family Staphylinidae ("rove beetles"). With 622 valid species assigned by 1987 to the subtribe Paederina (''Paederus'' and its close allies), and with all but 148 within ''Paederus'' itself, the genus is large. Due to toxins in the hemolymph of some species within this genus, it has given its name to paederus dermatitis, a characteristic skin irritation that occurs if one of the insects is crushed against skin. That name, Paederus dermatitis, is a poor choice because, decades earlier, the affliction had been called dermatitis linearis, a name that works in all languages, not just English, because of its Latin origin; the name Paederus dermatitis is also inappropriate because it has shown to be caused by (a) only a few species of the genus Paederus, but (b) also a few species that belong to closely related genera (that are not ''Paederus'') within the subtribe Paederina. A scholarly paper in 2002 suggested that a ''Paederus'' species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paederus Littoralis December 2016-1
''Paederus'' is a genus of small beetles of the family Staphylinidae ("rove beetles"). With 622 valid species assigned by 1987 to the subtribe Paederina (''Paederus'' and its close allies), and with all but 148 within ''Paederus'' itself, the genus is large. Due to toxins in the hemolymph of some species within this genus, it has given its name to paederus dermatitis, a characteristic skin irritation that occurs if one of the insects is crushed against skin. That name, Paederus dermatitis, is a poor choice because, decades earlier, the affliction had been called dermatitis linearis, a name that works in all languages, not just English, because of its Latin origin; the name Paederus dermatitis is also inappropriate because it has shown to be caused by (a) only a few species of the genus Paederus, but (b) also a few species that belong to closely related genera (that are not ''Paederus'') within the subtribe Paederina. A scholarly paper in 2002 suggested that a ''Paederus'' species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psymberin
Psymberin, also known as irciniastatin A, is a cytotoxin derived from sea sponges. It was discovered by two independent research groups, one led by Dr. Phil Crews and one led by Dr. Jean Schmidt, in 2004. Psymberin was found to be highly bioactive as it showed LC50s at nanomolar concentrations against various types of tumors. Biosynthesis The biosynthesis of psymberin became of interest when it was found to have a very similar structure to pederin, a natural product derived from the beetle genus ''Paederus''. This led researchers to investigate the genes of the organism that code for the respective natural product. A trans-AT polyketide synthase cluster, designated as the ''Psy'' cluster, contained two large groups of genes coding for two PKSs. The smaller gene group, ''psyA'', encoded a PKS with three modules, while the larger ''psyD'' encoded a ten module PKS. This ten module PsyD protein is, to date, the protein with the highest reported number of PKS modules. Large port ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paederus Dermatitis
Paederus dermatitis, medically known as dermatitis linearis, is a skin irritation resulting from contact with the hemolymph of certain rove beetles, a group that belongs to the insect order Coleoptera and the genus ''Paederus''. Other local names given to Paederus dermatitis include spider-lick, whiplash dermatitis, and Nairobi fly dermatitis. Rove beetles do not bite or sting but cause skin irritations and blisters when accidentally brushed or crushed against the skin provoking them to release their coelemic fluid which contains a strong blistering chemical. The active agent in the coelemic fluid is commonly referred to as pederin, although depending on the beetle species it may be one of several similar molecules including pederone and pseudopederin. "Blister beetle dermatitis", a term more properly used for the different dermatitis caused by cantharidin from blister beetles, is also sometimes used to describe paederus dermatitis caused by rove beetles. Diagnosis and treatmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vesicant
A blister agent (or vesicant), is a chemical compound that causes severe skin, eye and mucosal pain and irritation. They are named for their ability to cause severe chemical burns, resulting in painful water blisters on the bodies of those affected. Although the term is often used in connection with large-scale burns caused by chemical spills or chemical warfare agents, some naturally occurring substances such as are also blister-producing agents (vesicants). [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moffatt Oxidation
Moffat is a former burgh and spa town in Dumfries and Galloway, Scotland. Moffat or Moffatt may also refer to: Places United States * Moffat, Colorado, a town * Moffat County, Colorado * Moffat Tunnel, a railroad tunnel in Colorado * Moffatt Township, Michigan * Moffat, Texas, an unincorporated community Elsewhere * Moffat Beach, Queensland, Australia * Mount Moffat, Antarctica * Moffat Hills, Scotland, a range of hills People * Moffat (surname), a list of people with the surname Moffat or Moffatt * Moffat (given name), a list of people with the given name Moffat or Moffatt * Clan Moffat, Scottish clan Arts and entertainment * The Moffatts, Canadian band * '' The Moffats'', a children's novel by Eleanor Estes * Irene Moffat, a character in the 1987 American fantasy comedy movie '' Harry and the Hendersons'' * Sarah Moffat, a fictional television character from ''Upstairs, Downstairs'' Other uses * Moffat (company), an appliance brand originally from Australia * Moffat Comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethers
In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. A typical example of the first group is the solvent and anaesthetic diethyl ether, commonly referred to simply as "ether" (). Ethers are common in organic chemistry and even more prevalent in biochemistry, as they are common linkages in carbohydrates and lignin. Structure and bonding Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetamides
Acetamide (systematic name: ethanamide) is an organic compound with the formula CH3CONH2. It is the simplest amide derived from acetic acid. It finds some use as a plasticizer and as an industrial solvent. The related compound ''N'',''N''-dimethylacetamide (DMA) is more widely used, but it is not prepared from acetamide. Acetamide can be considered an intermediate between acetone, which has two methyl (CH3) groups either side of the carbonyl (CO), and urea which has two amide (NH2) groups in those locations. Acetamide is also a naturally occurring mineral with the IMA symbol: Ace. Production Laboratory scale Acetamide can be produced in the laboratory from ammonium acetate by dehydration: : H4CH3CO2] → CH3C(O)NH2 + H2O Alternatively acetamide can be obtained in excellent yield via ammonolysis of acetylacetone under conditions commonly used in reductive amination. It can also be made from anhydrous acetic acid, acetonitrile and very well dried hydrogen chloride gas, using a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cycloheximide
Cycloheximide is a naturally occurring fungicide produced by the bacterium ''Streptomyces griseus''. Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied ''in vitro'' (''i.e.'' outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium. Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects (including birth defects and toxicity to sperm), cycloheximide is generally used only in ''in vitro'' research applications, and is not suitable for human use as a therapeutic compound. Although it has been used as a fungicide in agricultural applications, this application is now decreasing a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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