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Paul W. Sternberg
Paul W. Sternberg is an American biologist. He does research for WormBase on ''C. elegans'', a model organism. Early life and education Paul Sternberg grew up in Long Island, New York. He attended Hampshire College for undergrad in Amherst, Massachusetts where he got a B.A. in 1978. After that he went to MIT where he received his PhD in Biology for work on nematode development with Robert Horvitz. He went on to do postdoctoral research with Ira Herskowitz in yeast molecular development at the University of California San Francisco. He is currently working at the California Institute of Technology as the Thomas Hunt Morgan Professor of Biology. WormBase Sternberg is a Primary investigator for WormBase. WormBase is a data repository for nematode biology. ''C. elegans'' has been used in studies of development and neurobiology. WormBase has information from nine species and five are from the genus '' Caenorhabditis'', one of which is ''C. elegans''. WormBase provides: a genome b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Model Organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Studying model organisms can be informative, but care must be taken when generalizing from one organism to another. In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resembles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hampshire College
Hampshire College is a Private college, private Liberal arts colleges in the United States, liberal arts college in Amherst, Massachusetts. It was opened in 1970 as an experiment in alternative education, in association with four other colleges in the Pioneer Valley: Amherst College, Smith College, Mount Holyoke College, and the University of Massachusetts Amherst. Together they are known as the Five College Consortium. The campus also houses the Yiddish Book Center, National Yiddish Book Center and Eric Carle Museum of Picture Book Art, Eric Carle Museum, and hosts the annual Hampshire College Summer Studies in Mathematics. The college is known for its alternative curriculum, self-directed academic concentrations, Progressivism, progressive politics, focus on portfolios rather than distribution requirements, and its reliance on narrative evaluations instead of grades and GPAs. Sixty-five percent of its alumni have at least one graduate degree and a quarter have founded their own ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the most prestigious and highly ranked academic institutions in the world. Founded in response to the increasing industrialization of the United States, MIT adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. MIT is one of three private land grant universities in the United States, the others being Cornell University and Tuskegee University. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River, and encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory, the Bates Center, and the Haystack Observatory, as well as affiliated laboratories such as the Broad and Whitehead Institutes. , 98 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ira Herskowitz
Ira Herskowitz (July 14, 1946 – April 28, 2003) was an American phage and yeast geneticist geneticist who studied genetic regulatory circuits and mechanisms. He was particularly noted for his work on mating type switching and cellular differentiation, largely using ''Saccharomyces cerevisiae'' as a model organism. Education Ira Herskowitz and his twin brother Joel were born in Brooklyn, New York on 14 July 1946. Their father Irwin Herskowitz was a ''Drosophila'' geneticist, at Indiana University and later at Saint Louis University. Ira Herskowitz became interested in bacteriophages when he studied with Robert Stuart Edgar at California Institute of Technology. After completing a degree in 1967, he entered Massachusetts Institute of Technology (MIT), where he studied the molecular biology of the lambda phage. Herskowitz worked with Ethan Signer, whose other students include Nancy Kleckner and Frederick M. Ausubel. He received his Ph.D. from MIT in 1971. He spent his final ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California Institute Of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasionally referred to as "CIT", most notably in its alma mater, but this is uncommon. is a private research university in Pasadena, California. Caltech is ranked among the best and most selective academic institutions in the world, and with an enrollment of approximately 2400 students (acceptance rate of only 5.7%), it is one of the world's most selective universities. The university is known for its strength in science and engineering, and is among a small group of institutes of technology in the United States which is primarily devoted to the instruction of pure and applied sciences. The institution was founded as a preparatory and vocational school by Amos G. Throop in 1891 and began attracting influential scientists such as George Ellery H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis
''Caenorhabditis'' is a genus of nematodes which live in bacteria-rich environments like compost piles, decaying dead animals and rotting fruit. The name comes from Greek: caeno- (καινός (caenos) = new, recent); rhabditis = rod-like (ῥάβδος (rhabdos) = rod, wand). In 1900, Maupas initially named the species ''Rhabditis elegans'', Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. The genus ''Caenorhabditis'' contains the noted model organism '' Caenorhabditis elegans'' and several other species for which a genome sequence is either available or currently being determined. The two most-studied species in this genus (''C. elegans'' and ''C. briggsae'') are both androdioecious (they have male and hermaphrodite sexes) whereas most other species are gonochoristic (they have male and female sexes). ''C. elegans'' is the type species of the genus. Ecology ''Caenorhabditis'' occupy various ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Ontology Consortium
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis. GO is part of a larger classification effort, the Open Biomedical Ontologies, being one of the Initial Candidate Members of the OBO Foundry. Whereas gene nomenclature focuses on gene and gene products, the Gene Ontology focuses on the function of the genes and gene products. The GO also extends the effort by using markup language to make the data (not only of the genes and their products but also of curated attributes) machine readab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulties in social interaction, verbal and nonverbal communication, and the presence of repetitive behavior and restricted interests. Other common signs include unusual responses to sensory stimuli. Autism is generally understood as a ''spectrum disorder'', which means that it can manifest differently in each person: any given autistic individual is likely to show some, but not all, of the characteristics associated with it, and the person may exhibit them to varying degrees. Some autistic people remain nonspeaking over the course of their lifespan, while others have relatively unimpaired spoken language. There is large variation in the level of support people require, and the same person may present differently at varying times. Historically ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRISPR-Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a dual RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary to the 20 nucleotide sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Panagrellus Redivivus
The free-living nematode ''Panagrellus redivivus'' (sour paste nematode, or beer mat nematode from its occurrence in constantly moist felt beer mats), is known to many aquarium enthusiasts and fish keepers as the microworm. It is a tiny roundworm used as the first food for larger kinds of newly-hatched fish, such as larval common carp. The microworm is widely used in aquaculture as food for a variety of fish and crustacean species. One of thirteen currently recognized species of ''Panagrellus'', ''P. redivivus'' is about 50 μm in diameter and just over 1 mm in length, barely visible to the naked eye. Subsisting on yeast, it is easily cultured at home on a substrate of flour paste or porridge inoculated with dry yeast. Females reach maturity in about three days and deliver live young rather than eggs, as most nematodes produce. The microworm has been used in genetic analysis studies, but not nearly as universally as its relative, ''Caenorhabditis elegans ''Caenorhabdi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Year Of Birth Missing (living People)
A year or annus is the orbital period of a planetary body, for example, the Earth, moving in its orbit around the Sun. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by change in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons are generally recognized: spring, summer, autumn and winter. In tropical and subtropical regions, several geographical sectors do not present defined seasons; but in the seasonal tropics, the annual wet and dry seasons are recognized and tracked. A calendar year is an approximation of the number of days of the Earth's orbital period, as counted in a given calendar. The Gregorian calendar, or modern calendar, presents its calendar year to be either a common year of 365 days or a leap year of 366 days, as do the Julian calendars. For the Gregorian calendar, the average length of the calendar year (the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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