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Paul Sigler
Paul B. Sigler ( – ) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University. Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim and Helen Hay Whitney Fellowships. He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others. Biography Prior to coming to Yale, he was a professor at the University of Chicago. He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955. After briefly practicing medicine and working as a researcher for the NIH, he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology working under David M. Blow before moving to the University of Chicago. Memorials A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memoria ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richmond, Virginia
(Thus do we reach the stars) , image_map = , mapsize = 250 px , map_caption = Location within Virginia , pushpin_map = Virginia#USA , pushpin_label = Richmond , pushpin_map_caption = Location within Virginia##Location within the contiguous United States , pushpin_relief = yes , coordinates = , subdivision_type = Country , subdivision_name = , subdivision_type1 = U.S. state, State , subdivision_name1 = , established_date = 1742 , , named_for = Richmond, London, Richmond, United Kingdom , government_type = , leader_title = List of mayors of Richmond, Virginia, Mayor , leader_name = Levar Stoney (Democratic Party (United States), D) , total_type = City , area_magnitude = 1 E8 , area_total_sq_mi = 62.57 , area_land_sq_mi = 59.92 , area_ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guggenheim Fellow
Guggenheim Fellowships are grants that have been awarded annually since by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the arts." Each year, the foundation issues awards in each of two separate competitions: * One open to citizens and permanent residents of the United States and Canada. * The other to citizens and permanent residents of Latin America and the Caribbean. The Latin America and Caribbean competition is currently suspended "while we examine the workings and efficacy of the program. The U.S. and Canadian competition is unaffected by this suspension." The performing arts are excluded, although composers, film directors, and choreographers are eligible. The fellowships are not open to students, only to "advanced professionals in mid-career" such as published authors. The fellows may spend the money as they see fit, as the purpose is to give fellows "b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University Faculty
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biochemists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biophysicists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Princeton University Alumni
Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the nine colonial colleges chartered before the American Revolution. It is one of the highest-ranked universities in the world. The institution moved to Newark in 1747, and then to the current site nine years later. It officially became a university in 1896 and was subsequently renamed Princeton University. It is a member of the Ivy League. The university is governed by the Trustees of Princeton University and has an endowment of $37.7 billion, the largest endowment per student in the United States. Princeton provides undergraduate and graduate instruction in the humanities, social sciences, natural sciences, and engineering to approximately 8,500 students on its main campus. It offers postgraduate degrees through the Princeton School of Publi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of University Of Chicago People
This list of University of Chicago people provides links to list articles that include the faculty members, researchers, graduates, and other students of the University of Chicago. The alumni of the university include graduates and attendees. Graduates are defined as those who hold Bachelor's, Master's, PhD, or equivalent degrees from the university, while attendees are those who studied at the university (excluding the summer term) but did not complete the program or obtain a degree. The faculty of the university include long-term faculty members and temporary academic staffs. The long-term faculty members consists of tenure/tenure-track and equivalent academic positions, while that of temporary academic staffs consists of lecturers (without tenure), postdoctoral researchers, visiting professors or scholars (visitors), and equivalent academic positions. List articles * List of University of Chicago alumni *List of University of Chicago faculty *List of University of Chicago Law Sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Guggenheim Fellowships Awarded In 1974
{{short description, None List of Guggenheim fellowship winners for 1974. United States and Canada fellows * Hazard Adams, Byron W. and Alice L. Lockwoood Emeritus Professor of Humanities; Professor of English, University of Washington. * Flavia Alaya, Professor of Literature and Cultural History, Ramapo College of New Jersey. * Edward Alexander, Professor of English, University of Washington. * Frederick J. Almgren Jr., deceased. Mathematics. * J. L. Alperin, Professor of Mathematics, University of Chicago. * Donald Appleyard, deceased. Urban Planning. * Michael Asher, artist, Los Angeles. * Jerold Stephen Auerbach, Professor of History, Wellesley College. * John Norman Austin, Professor of Classics, University of Massachusetts Amherst. * Andrew S. Bajer, Professor of Biology, University of Oregon. * Paul Thornell Baker, Professor Emeritus of Anthropology, Pennsylvania State University. * Korkut Bardakci, Professor of Physics, University of California, Berkeley. * Joh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trp Repressor
Tryptophan repressor (or trp repressor) is a transcription factor involved in controlling amino acid metabolism. It has been best studied in ''Escherichia coli'', where it is a dimeric protein that regulates transcription of the 5 genes in the tryptophan operon. When the amino acid tryptophan is plentiful in the cell, it binds to the protein, which causes a conformational change in the protein. The repressor complex then binds to its operator sequence in the genes it regulates, shutting off the genes. One of the genes regulated by trp repressor, trpR, codes for the tryptophan repressor protein itself. This is a form of feedback regulation. However, these genes are located on different operons. The (tryptophan) repressor is a 25 kD protein homodimer which regulates transcription of the tryptophan biosynthetic pathway in bacteria. There are 5 operons which are regulated by trpR: the ''trpEDCBA'', ''trpR'', ''AroH'', ''AroL'', and ''mtr'' operons. Mechanism When the amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leucine Zipper
A leucine zipper (or leucine scissors) is a common three-dimensional structural motif in proteins. They were first described by Landschulz and collaborators in 1988 when they found that an enhancer binding protein had a very characteristic 30-amino acid segment and the display of these amino acid sequences on an idealized alpha helix revealed a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. The polypeptide segments containing these periodic arrays of leucine residues were proposed to exist in an alpha-helical conformation and the leucine side chains from one alpha helix interdigitate with those from the alpha helix of a second polypeptide, facilitating dimerization. Leucine zippers are a dimerization motif of the bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. The bZIP domain is 60 to 80 amino acids in length with a highly conserved DNA binding basic region and a more diversified leucin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TATA-binding Protein
The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP gene family TBP is a member of a small gene family of TBP-related factors. The first TBP-related factor (TRF/TRF1) was identified in the fruit fly Drosophila, but appears to be fly or insect-specific. Subsequently TBPL1/TRF2 was found in the genomes of many metazoans, whereas vertebrate genomes encode a third vertebrate family member, TBPL2/TRF3. In specific cell types or on specific promoters TBP can be replaced by one of these TBP-related factors, some of which interact with the TATA box similarly to TBP. Role as transcription factor TBP is a subunit of the eukaryotic general transcription factor TFIID. TFIID is the first protein to bind to DNA during the formation of the transcription preinitiation complex of RNA po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GroEL
GroEL is a protein which belongs to the chaperonin family of molecular chaperones, and is found in many bacteria. It is required for the proper folding of many proteins. To function properly, GroEL requires the lid-like cochaperonin protein complex GroES. In eukaryotes the organellar proteins Hsp60 and Hsp10 are structurally and functionally nearly identical to GroEL and GroES, respectively, due to their endosymbiotic origin. HSP60 is implicated in mitochondrial protein import and macromolecular assembly. It may facilitate the correct folding of imported proteins, and may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSP60 interacts with HRAS and with HBV protein X and HTLV-1 protein p40tax. HSP60 belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB. Alternate Names: 60 kDa chaperonin, Chaperonin 60, CPN60, Heat shock ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
