Paul B. Sigler ( – /ref>) was the Henry Ford II Professor of Molecular
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. ...
and
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
at
Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...
HHMI
The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fi ...
Helen Hay Whitney
Helen Julia Hay Whitney (March 11, 1875 – September 24, 1944) was an American poet, writer, racehorse owner/breeder, socialite, and philanthropist. She was a member by marriage of the prominent Whitney family of New York.
Early life
She was ...
Fellowships. He is noted for pioneering studies of Phospholipase A2 and
trp repressor
Tryptophan repressor (or trp repressor) is a transcription factor involved in controlling amino acid metabolism. It has been best studied in ''Escherichia coli'', where it is a dimeric protein that regulates transcription of the 5 genes in the t ...
amongst many others.
Biography
Prior to coming to Yale, he was a professor at the
University of Chicago
The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private university, private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park, Chicago, Hyde Park neighborhood. The University of Chic ...
. He received his MD from
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
in 1959 and his undergraduate degree from
Princeton University
Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ...
in 1955. After briefly practicing medicine and working as a researcher for the
NIH
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
, he would go on to earn a second doctorate, a PhD, from
Cambridge University
The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III of England, Henry III in 1231, Cambridge is the world' ...
at the
Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
working under David M. Blow before moving to the University of Chicago.
Memorials
A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of
Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...
. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. Yale also has sponsored Paul Sigler memorial symposia in the past. The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.
Death
Paul Sigler died on January 11, 2000 at
New Haven, Connecticut
New Haven is a city in the U.S. state of Connecticut. It is located on New Haven Harbor on the northern shore of Long Island Sound in New Haven County, Connecticut and is part of the New York City metropolitan area. With a population of 134 ...
, US, 39 days before his 66th birthday.
Selected publications
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See also
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List of Guggenheim Fellowships awarded in 1974 {{short description, None
List of Guggenheim fellowship winners for 1974.
United States and Canada fellows
* Hazard Adams, Byron W. and Alice L. Lockwoood Emeritus Professor of Humanities; Professor of English, University of Washington.
* Flavi ...
*
List of University of Chicago people
This list of University of Chicago people provides links to list articles that include the faculty members, researchers, graduates, and other students of the University of Chicago. The alumni of the university include graduates and attendees. Grad ...