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PDC-APB
PDC-APB, or 3-pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate), is a drug candidate under evaluation to determine if it might protect against contact dermatitis caused by urishiol from poison ivy, poison oak, and poison sumac. History The compound is one of a class of compounds developed through University of Mississippi research by Mahmoud ElSohly, Waseem Gul, and Mohammad Khalid Ashfaq. Work on the compound is ongoing under Hapten Sciences, who licensed the university's research in 2010. Evaluation as a drug candidate The compound has been evaluated in two Phase I clinical trials, and a third Phase I randomized controlled trial A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical te ..., with a secondary objective of evaluating the effect of treatment on urishiol sen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mahmoud ElSohly
Mahmoud A. ElSohly is an Egyptian-born American pharmacologist known for his research into cannabis. He is a professor of pharmaceutics and research professor at the Research Institute of Pharmaceutical Sciences at the University of Mississippi. He is also the director of the University of Mississippi's Marijuana Research Project, the only legal source of marijuana that can be used for medical research in the United States. He is also the president and laboratory director of ElSohly Laboratories, Incorporated. Education and career ElSohly received his B.S. and M.S. from Cairo University, after which he received his Ph.D. from the University of Pittsburgh. He began working at the University of Mississippi in 1976. In 1980, he became the director of their Marijuana Project. In addition to his work on cannabis, ElSohly's research on urushiol led to the development of PDC-APB, a candidate for a vaccine against skin irritation from poison ivy. Books * * * References Ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Candidate
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate pharmaceutical drug, medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipity, serendipitous discovery, History of penicillin, as with penicillin. More recently, chemical library, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After Human Genome Project, sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contact Dermatitis
Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Symptoms of contact dermatitis can include itchy or dry skin, a red rash, bumps, blisters, or swelling. These rashes are not contagious or life-threatening, but can be very uncomfortable. Contact dermatitis results from either exposure to allergens (allergic contact dermatitis), or irritants (irritant contact dermatitis). Allergic contact dermatitis involves a delayed type of hypersensitivity and previous exposure to an allergen to produce a reaction. Irritant contact dermatitis is the most common type and represents 80% of all cases. It is caused by prolonged exposure to irritants, leading to direct injury of the epidermal cells of the skin, which activates an immune response, resulting in an inflammatory cutaneous reaction. Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight. Diagnosis of allergic contact dermatitis can o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urishiol
Urushiol is an oily mixture of organic compounds with allergenic properties found in plants of the family Anacardiaceae, especially '' Toxicodendron'' ''spp.'' (e.g., poison oak, Chinese lacquer tree, poison ivy, poison sumac), ''Comocladia spp.'' (maidenplums), ''Metopium spp''. (poisonwood), and also in parts of the mango tree as well as the fruit of the cashew tree. In most individuals, urushiol causes an allergic skin rash on contact, known as urushiol-induced contact dermatitis. The name urushiol is derived from the Japanese word for the lacquer tree, . The oxidation and polymerization of urushiol in the tree's sap in the presence of moisture allows it to form a hard lacquer, which is used to produce traditional Chinese, Korean and Japanese lacquerware. History Although urushiol-containing lacquers and their skin-irritating properties were well known in East Asia for several millennia, its first recorded Western texts were in 1624 by John Smith and he initially ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poison Oak '' or Atlantic poison oak, found in the southeastern United States
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Poison oak refers to two plant species in the genus ''Toxicodendron,'' both of which can cause skin irritation: *''Toxicodendron diversilobum'' or Western poison oak, found in western North America *''Toxicodendron pubescens ''Toxicodendron pubescens'' (syn. ''Rhus pubescens''), commonly known as Atlantic poison oak, is an upright shrub that can grow to 1 metre (3 feet) tall. Its leaves are 15 centimetres (6 inches) long, alternate, with three le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poison Sumac
''Toxicodendron vernix'', commonly known as poison sumac, or swamp-sumach, is a woody shrub or small tree growing to 9 metres (30 feet) tall. It was previously known as ''Rhus vernix''. This plant is also known as thunderwood, particularly where it occurs in the southern United States. All parts of the plant contain a resin called urushiol that causes skin and mucous membrane irritation to humans. When the plant is burned, inhalation of the smoke may cause the rash to appear on the lining of the lungs, causing extreme pain and possibly fatal respiratory difficulty. Description Poison sumac is a shrub or small tree, growing up to nearly in height. Each pinnate leaf has 7–13 leaflets, each of which is long. These are oval-to-oblong; acuminate (tapering to a sharp point); cuneate (wedge-shaped) at the base; undulate (wavy-edged); with an underside that is glabrous (hairless) or slightly pubescent (down-like hair) beneath. The stems along the leaflets are red and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Mississippi
The University of Mississippi (byname Ole Miss) is a public research university that is located adjacent to Oxford, Mississippi, and has a medical center in Jackson. It is Mississippi's oldest public university and its largest by enrollment. The Mississippi Legislature chartered the university on February 24, 1844, and four years later it admitted its first 80 students. During the Civil War, the university operated as a Confederate hospital and narrowly avoided destruction by Ulysses S. Grant's forces. In 1962, during the civil rights movement, a race riot occurred on campus when segregationists tried to prevent the enrollment of African American student James Meredith. The university has since taken measures to improve its image. The university is closely associated with writer William Faulkner, and owns and manages his former Oxford home Rowan Oak, which with other on-campus sites Barnard Observatory and Lyceum–The Circle Historic District, is listed on the National Reg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waseem Gul
Wasim, Wassim or Waseem () () () is a masculine Arabic given name and surname meaning ''Handsome'', ''Graceful'' or ''Good Looking''. People *Abbas Wasim Efendi, Ottoman astronomer *Abdul Waseem, Pakistani politician *Ahmed Waseem Razeek, German footballer * Imad Wasim, British-Pakistani cricketer * Mohammad Wasim, Pakistani cricketer *Muhammad Waseem, Pakistani boxer *Saira Wasim, Pakistani artist *Syed Waseem Hussain, Pakistani politician *Waseem Abbas, Pakistani actor *Waseem Ahmad, Pakistani hockey player *Waseem Akhtar, Pakistani politician *Waseem Al-Bzour, Jordanian football player *Waseem Badami, Pakistani journalist * Waseem Bhatti, French cricketer * Waseem Mirza, British radio and television reporter and presenter * Waseem Shaikh, South African actor * Wasim (Guantanamo captive 338), Saudi detainee *Wasim Akram, Pakistani cricketer *Wasim Barelvi, Indian Urdu poet * Wasim Bari, Pakistani cricketer *Wasim Feroze, Indian footballer *Wasim Haider, Pakistani cricketer * Wasim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mohammad Khalid Ashfaq
Muhammad ( ar, مُحَمَّد; 570 – 8 June 632 CE) was an Arab religious, social, and political leader and the founder of Islam. According to Islamic doctrine, he was a prophet divinely inspired to preach and confirm the monotheistic teachings of Adam, Abraham, Moses, Jesus, and other prophets. He is believed to be the Seal of the Prophets within Islam. Muhammad united Arabia into a single Muslim polity, with the Quran as well as his teachings and practices forming the basis of Islamic religious belief. Muhammad was born approximately 570CE in Mecca. He was the son of Abdullah ibn Abd al-Muttalib and Amina bint Wahb. His father Abdullah was the son of Quraysh tribal leader Abd al-Muttalib ibn Hashim, and he died a few months before Muhammad's birth. His mother Amina died when he was six, leaving Muhammad an orphan. He was raised under the care of his grandfather, Abd al-Muttalib, and paternal uncle, Abu Talib. In later years, he would periodically seclude himse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hapten Sciences
In immunology, haptens are small molecules that elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself (in general, only large molecules, infectious agents, or insoluble foreign matter can elicit an immune response in the body). Once the body has generated antibodies to a hapten-carrier adduct, the small-molecule hapten may also be able to bind to the antibody, but it will usually not initiate an immune response; usually only the hapten-carrier adduct can do this. Sometimes the small-molecule hapten can even block immune response to the hapten-carrier adduct by preventing the adduct from binding to the antibody, a process called ''hapten inhibition''. The mechanisms of absence of immune response may vary and involve complex immunological mechanisms, but can include absent or insufficient co-stimulatory signals from antigen-presenting cells. Haptens have been used to stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phase I Clinical Trials
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
