PDC-APB, or 3-pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate),
is a
drug candidate
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate pharmaceutical drug, medications are discovered.
Historically, drugs were discovered by identifying the active ingredient from tradit ...
under evaluation to determine if it might protect against
contact dermatitis caused by
urishiol from
poison ivy,
poison oak Poison oak refers to two plant species in the genus ''Toxicodendron,'' both of which can cause skin irritation:
*''Toxicodendron diversilobum'' or Western poison oak, found in western North America
*''Toxicodendron pubescens
''Toxicodendron pub ...
, and
poison sumac.
History
The compound is one of a class of compounds developed through
University of Mississippi
The University of Mississippi (byname Ole Miss) is a public research university that is located adjacent to Oxford, Mississippi, and has a medical center in Jackson. It is Mississippi's oldest public university and its largest by enrollment.
...
research
by
Mahmoud ElSohly
Mahmoud A. ElSohly is an Egyptian-born American pharmacologist known for his research into cannabis. He is a professor of pharmaceutics and research professor at the Research Institute of Pharmaceutical Sciences at the University of Mississippi. ...
,
Waseem Gul, and
Mohammad Khalid Ashfaq.
Work on the compound is ongoing under
Hapten Sciences,
who licensed the university's research in 2010.
Evaluation as a drug candidate
The compound has been evaluated in two
Phase I clinical trials
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...
, and a third Phase I
randomized controlled trial
A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical te ...
, with a secondary objective of evaluating the effect of treatment on urishiol sensitivity, is due to be completed in December 2022.
See also
*
Urushiol-induced contact dermatitis
References
{{improve categories, date=July 2022
Dermatologic drugs