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Oskar Fischer
Oskar Fischer (12 April 1876 – 28 February 1942) was a Czech academic, psychiatrist and neuropathologist whose studies on dementia and Alzheimer disease were rediscovered in 2008. Early life and education Fischer was born into a German-speaking family in Slaný in central Bohemia, 25 km northwest of Prague, on 12 April 1876. His father was the manager of an agricultural estate there. He completed primary and secondary education in Slaný. Then he attended the medical schools of both Prague University and Strasbourg University, and graduated from Prague University in 1900. Career Fischer began his career at the department of pathological anatomy of German University in 1900. Next, he joined the department of psychiatry of the same university in 1902, and worked there until 1919. Fischer served as a physician-in-chief at the division of neurology and psychiatry of the second garrison hospital in Prague during World War I, and treated many soldiers who had experienced ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Slaný
Slaný (; german: Schlan) is a town in Kladno District in the Central Bohemian Region of the Czech Republic. It has about 16,000 inhabitants. The historic town centre is well preserved and is protected by law as an urban monument zone. Administrative parts Villages of Blahotice, Dolín, Lotouš, Kvíc, Kvíček, Netovice, Otruby, Trpoměchy and Želevčice are administrative parts of Slaný. Geography Slaný is located about northwest of Prague, in the Prague Plateau. The Červený Creek flows through the municipal territory from the southwest to the northeast. Its dominant feature is the hill Slánská hora, with above sea level. History The Wenceslaus Hajek's chronicle records Slaný as having been founded in 750, at the site of a salt spring below the Slánská hora Hill (''slaný'' is a Czech word for "salty"). The first written mention of Slaný is from 1262. The town grew as a result of its location on the trade route between Prague and Saxony. The Benedictines establi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Munich
Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by population, third-largest city in Germany, after Berlin and Hamburg, and thus the largest which does not constitute its own state, as well as the List of cities in the European Union by population within city limits, 11th-largest city in the European Union. The Munich Metropolitan Region, city's metropolitan region is home to 6 million people. Straddling the banks of the River Isar (a tributary of the Danube) north of the Northern Limestone Alps, Bavarian Alps, Munich is the seat of the Bavarian Regierungsbezirk, administrative region of Upper Bavaria, while being the population density, most densely populated municipality in Germany (4,500 people per km2). Munich is the second-largest city in the Bavarian dialects, Bavarian dialect area, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Occupation Of Czechoslovakia
German(s) may refer to: * Germany (of or related to) ** Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Germanic peoples (Roman times) * German language **any of the Germanic languages * German cuisine, traditional foods of Germany People * German (given name) * German (surname) * Germán, a Spanish name Places * German (parish), Isle of Man * German, Albania, or Gërmej * German, Bulgaria * German, Iran * German, North Macedonia * German, New York, U.S. * Agios Germanos, Greece Other uses * German (mythology), a South Slavic mythological being * Germans (band), a Canadian rock band * "German" (song), a 2019 song by No Money Enterprise * ''The German'', a 2008 short film * "The Germans", an episode of ''Fawlty Towers'' * ''The German'', a nickname for Congolese rebel André Kisase Ngandu See also * Germanic (other) * Ger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti Semitism
Antisemitism (also spelled anti-semitism or anti-Semitism) is hostility to, prejudice towards, or discrimination against Jews. A person who holds such positions is called an antisemite. Antisemitism is considered to be a form of racism. Antisemitism has historically been manifested in many ways, ranging from expressions of hatred of or discrimination against individual Jews to organized pogroms by mobs, police forces, or genocide. Although the term did not come into common usage until the 19th century, it is also applied to previous and later anti-Jewish incidents. Notable instances of persecution include the Rhineland massacres preceding the First Crusade in 1096, the Edict of Expulsion from England in 1290, the 1348–1351 persecution of Jews during the Black Death, the massacres of Spanish Jews in 1391, the persecutions of the Spanish Inquisition, the expulsion from Spain in 1492, the Cossack massacres in Ukraine from 1648 to 1657, various anti-Jewish pogroms in the Russi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles University In Prague
Charles University ( cs, Univerzita Karlova, UK; la, Universitas Carolina; german: Karls-Universität), also known as Charles University in Prague or historically as the University of Prague ( la, Universitas Pragensis, links=no), is the oldest and largest university in the Czech Republic. It is one of the List of oldest universities in continuous operation, oldest universities in Europe in continuous operation. Today, the university consists of 17 faculties located in Prague, Hradec Králové, and Plzeň. Charles University belongs among the top three universities in Central and Eastern Europe. It is ranked around 200–300 in the world. History Medieval university (1349–1419) The establishment of a medieval university in Prague was inspired by Holy Roman Emperor Charles IV, Holy Roman Emperor, Charles IV. He asked his friend and ally, Pope Clement VI, to do so. On 26 January 1347 the pope issued the bull establishing a university in Prague, modeled on the University of Paris, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge University
, mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Scholars of the University of Cambridge , type = Public research university , endowment = £7.121 billion (including colleges) , budget = £2.308 billion (excluding colleges) , chancellor = The Lord Sainsbury of Turville , vice_chancellor = Anthony Freeling , students = 24,450 (2020) , undergrad = 12,850 (2020) , postgrad = 11,600 (2020) , city = Cambridge , country = England , campus_type = , sporting_affiliations = The Sporting Blue , colours = Cambridge Blue , website = , logo = University of Cambridge logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michel Goedert
Michel Goedert FRS, FMedSci is a Luxembourgish-British neuroscientist and former Head of Neurobiology, at the MRC Laboratory of Molecular Biology. Goedert was born and raised in Luxembourg. After finishing his medical studies at the University of Basel in 1986, he started working at the Medical Research Council Laboratory of Molecular Biology affiliated with the University of Cambridge. Goedert was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1996, the Potamkin Prize in 1998 and the ''European Grand Prix for Research'' by the Foundation for Research on Alzheimer's disease in 2014. In 2018 he was one of four recipients of the Grete Lundbeck European Brain Research Prize with the citation "For their groundbreaking research on the genetic and molecular basis of Alzheimer's disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California At Irvine College Of Medicine
The University of California, Irvine School of Medicine (UC Irvine School of Medicine or UCI School of Medicine) is an LCME accredited medical school, co-located in Orange County's cities of Irvine on the University of California, Irvine campus and Orange at the UC Irvine Medical Center. Of the medical schools evaluated for its 2013 edition (released March 13, 2012), ''U.S News & World Report'' ranked the school 43rd in Research and 61st in Primary Care. The school was founded in 1896 by A.C. Moore and is the oldest continually operating medical school in the greater Los Angeles area. The school is affiliated with UC Irvine Medical Center and the Children's Hospital of Orange County. History Although the School of Medicine joined UC Irvine in 1967, its history goes back more than 100 years. In 1896, the Pacific College of Osteopathy was founded in the city of Anaheim. Upon moving to Los Angeles in 1904, and through a merger with the Los Angeles College of Osteopathy, the Calif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histopathological
Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία ''-logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks"). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senile Dementia
Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning, and a greater cognitive decline than what is caused by normal aging. Several diseases and injuries to the brain, such as a stroke, can give rise to dementia. However, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microorganisms
A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in older texts. The informal synonym ''microbe'' () comes from μικρός, mikrós, "small" and βίος, bíos, "life". is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s, Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera, diphtheria, and anthrax. Because micr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurofibrillary Tangles
Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies. Formation Neurofibrillary tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate, or group, in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or " paired helical filaments"). The precise mechanism of tangle formation is not completely understood, and it is still controversial whether tangles are a primary causative factor in disease or play a more peripheral role. Cytoskeletal changes Three different maturation states of NFT have been defined using anti-tau and anti-ubiquitin immunostaining. At stage 0 there are morphologically normal pyramidal cells showi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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