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Optical Tomography
Optical tomography is a form of computed tomography that creates a digital volumetric model of an object by reconstructing images made from light transmitted and scattered through an object. Optical tomography is used mostly in medical imaging research. Optical tomography in industry is used as a sensor of thickness and internal structure of semiconductors. Principle Optical tomography relies on the object under study being at least partially light-transmitting or translucent, so it works best on soft tissue, such as breast and brain tissue. The high scatter-based attenuation involved is generally dealt with by using intense, often pulsed or intensity modulated, light sources, and highly sensitive light sensors, and the use of infrared light at frequencies where body tissues are most transmissive. Soft tissues are highly scattering but weakly absorbing in the near-infrared and red parts of the spectrum, so that this is the wavelength range usually used. Types Diffuse optical t ...
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Scattering
Scattering is a term used in physics to describe a wide range of physical processes where moving particles or radiation of some form, such as light or sound, are forced to deviate from a straight trajectory by localized non-uniformities (including particles and radiation) in the medium through which they pass. In conventional use, this also includes deviation of reflected radiation from the angle predicted by the law of reflection. Reflections of radiation that undergo scattering are often called ''diffuse reflections'' and unscattered reflections are called ''specular'' (mirror-like) reflections. Originally, the term was confined to light scattering (going back at least as far as Isaac Newton in the 17th century). As more "ray"-like phenomena were discovered, the idea of scattering was extended to them, so that William Herschel could refer to the scattering of "heat rays" (not then recognized as electromagnetic in nature) in 1800. John Tyndall, a pioneer in light scattering researc ...
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Computed Tomography Laser Mammography
Computed tomography laser mammography (CTLM) is the trademark of Imaging Diagnostic Systems, Inc. (IDSI, United States) for its optical tomographic technique for female breast imaging. This medical imaging technique uses laser energy in the near infrared region of the spectrum, to detect angiogenesis in the breast tissue. It is optical molecular imaging for hemoglobin both oxygenated and deoxygenated. The technology uses laser in the same way computed tomography uses X-Rays, these beams travel through tissue and suffer attenuation. A laser detector measures the intensity drop and the data is collected as the laser detector moves across the breast creating a tomography image. CTLM images show hemoglobin distribution in a tissue and can detect areas of Angiogenesis surrounding malignant tumors, that stimulate this angiogenesis to obtain nutrients for growth. History Breast cancer affects 1 in 8 women, and an estimated 27% of people live at least 5 years after being diagno ...
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Diffuse Optical Imaging
Diffuse optical imaging (DOI) is a method of imaging using near-infrared spectroscopy (NIRS) or fluorescence-based methods. When used to create 3D volumetric models of the imaged material DOI is referred to as diffuse optical tomography, whereas 2D imaging methods are classified as diffuse optical imaging. The technique has many applications to neuroscience, sports medicine, wound monitoring, and cancer detection. Typically DOI techniques monitor changes in concentrations of oxygenated and deoxygenated hemoglobin and may additionally measure redox states of cytochromes. The technique may also be referred to as diffuse optical tomography (DOT), near infrared optical tomography (NIROT) or fluorescence diffuse optical tomography (FDOT), depending on the usage. In neuroscience, functional measurements made using NIR wavelengths, DOI techniques may classify as functional near infrared spectroscopy fNIRS. Physical mechanism Biological tissues can be considered strongly diffusive me ...
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Optical Coherence Tomography
Optical coherence tomography (OCT) is an imaging technique that uses low-coherence light to capture micrometer-resolution, two- and three-dimensional images from within optical scattering media (e.g., biological tissue). It is used for medical imaging and industrial nondestructive testing (NDT). Optical coherence tomography is based on low-coherence interferometry, typically employing near-infrared light. The use of relatively long wavelength light allows it to penetrate into the scattering medium. Confocal microscopy, another optical technique, typically penetrates less deeply into the sample but with higher resolution. Depending on the properties of the light source ( superluminescent diodes, ultrashort pulsed lasers, and supercontinuum lasers have been employed), optical coherence tomography has achieved sub-micrometer resolution (with very wide-spectrum sources emitting over a ~100 nm wavelength range). Optical coherence tomography is one of a class of optical tom ...
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Inverse Filter
Signal processing is an electrical engineering subfield that focuses on analysing, modifying, and synthesizing signals such as sound, images, and scientific measurements. For example, with a filter ''g'', an inverse filter ''h'' is one such that the sequence of applying ''g'' then ''h'' to a signal results in the original signal. Software or electronic inverse filters are often used to compensate for the effect of unwanted environmental filtering of signals. In speech science In all proposed models for the production of human speech, an important variable is the waveform of the airflow, or volume velocity, at the glottis. The glottal volume velocity waveform provides the link between movements of the vocal folds and the acoustical results of such movements, in that the glottis acts approximately as a source of volume velocity. That is, the impedance of the glottis is usually much higher than that of the vocal tract, and so glottal airflow is controlled mostly (but not entirely) by ...
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Confocal
In geometry, confocal means having the same foci: confocal conic sections. * For an optical cavity consisting of two mirrors, confocal means that they share their foci. If they are identical mirrors, their radius of curvature, ''R''mirror, equals ''L'', where ''L'' is the distance between the mirrors. * In conic sections, it is said of two ellipses, two hyperbolas, or an ellipse and a hyperbola which share both foci with each other. If an ellipse and a hyperbola are confocal, they are perpendicular to each other. * In optics, it means that one focus or image point of one lens is the same as one focus of the next lens. See also *Confocal laser scanning microscopy *Confocal microscopy Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser confocal scanning microscopy (LCSM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a sp ... * {{set index article, mathematics Elementary geo ...
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Deconvolution
In mathematics, deconvolution is the operation inverse to convolution. Both operations are used in signal processing and image processing. For example, it may be possible to recover the original signal after a filter (convolution) by using a deconvolution method with a certain degree of accuracy. Due to the measurement error of the recorded signal or image, it can be demonstrated that the worse the SNR, the worse the reversing of a filter will be; hence, inverting a filter is not always a good solution as the error amplifies. Deconvolution offers a solution to this problem. The foundations for deconvolution and time-series analysis were largely laid by Norbert Wiener of the Massachusetts Institute of Technology in his book ''Extrapolation, Interpolation, and Smoothing of Stationary Time Series'' (1949). The book was based on work Wiener had done during World War II but that had been classified at the time. Some of the early attempts to apply these theories were in the fields of ...
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Diffusion Equation
The diffusion equation is a parabolic partial differential equation. In physics, it describes the macroscopic behavior of many micro-particles in Brownian motion, resulting from the random movements and collisions of the particles (see Fick's laws of diffusion). In mathematics, it is related to Markov processes, such as random walks, and applied in many other fields, such as materials science, information theory, and biophysics. The diffusion equation is a special case of the convection–diffusion equation, when bulk velocity is zero. It is equivalent to the heat equation under some circumstances. Statement The equation is usually written as: where is the density of the diffusing material at location and time and is the collective diffusion coefficient for density at location ; and represents the vector differential operator del. If the diffusion coefficient depends on the density then the equation is nonlinear, otherwise it is linear. The equation above applies wh ...
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Digital Data
Digital data, in information theory and information systems, is information represented as a string of discrete symbols each of which can take on one of only a finite number of values from some alphabet, such as letters or digits. An example is a text document, which consists of a string of alphanumeric characters . The most common form of digital data in modern information systems is ''binary data'', which is represented by a string of binary digits (bits) each of which can have one of two values, either 0 or 1. Digital data can be contrasted with ''analog data'', which is represented by a value from a continuous range of real numbers. Analog data is transmitted by an analog signal, which not only takes on continuous values, but can vary continuously with time, a continuous real-valued function of time. An example is the air pressure variation in a sound wave. The word ''digital'' comes from the same source as the words digit and ''digitus'' (the Latin word for ''finger'' ...
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Photon Diffusion
Photon diffusion is a situation where photons travel through a material without being absorbed, but rather undergoing repeated scattering events which change the direction of their path. The path of any given photon is then effectively a random walk. A large ensemble of such photons can be said to exhibit diffusion in the material, and can be described with a diffusion equation. Astrophysics In astrophysics, photon diffusion occurs inside a stellar atmosphere. To describe this phenomenon, one should develop the transfer equation in moments and use the Eddington approximation to radiative transfer (i.e. the diffusion approximation). In 3D the results are two equations for the photon energy flux: :\vec F = -\frac\vec \nabla U, :\vec \nabla \cdot \vec F = 0, where \sigma is the opacity. By substituting the first equation into the second, one obtains the diffusion equation for the photon energy density: :\nabla^2 U -\frac\vec \nabla U \cdot \vec \nabla \sigma=0. Medical science In medi ...
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Infrared
Infrared (IR), sometimes called infrared light, is electromagnetic radiation (EMR) with wavelengths longer than those of visible light. It is therefore invisible to the human eye. IR is generally understood to encompass wavelengths from around 1 millimeter (300 GHz) to the nominal red edge of the visible spectrum, around 700  nanometers (430  THz). Longer IR wavelengths (30 μm-100 μm) are sometimes included as part of the terahertz radiation range. Almost all black-body radiation from objects near room temperature is at infrared wavelengths. As a form of electromagnetic radiation, IR propagates energy and momentum, exerts radiation pressure, and has properties corresponding to both those of a wave and of a particle, the photon. It was long known that fires emit invisible heat; in 1681 the pioneering experimenter Edme Mariotte showed that glass, though transparent to sunlight, obstructed radiant heat. In 1800 the astronomer Sir William Herschel discovered ...
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