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Onnamide A
Onnamide A is a bioactive natural product found in ''Theonella swinhoei'', a species of marine sponge whose genus is well known for yielding a diverse set of biologically active natural products, including the swinholides and polytheonamides. It bears structural similarities to the pederins, a family of compounds known to inhibit protein synthesis in eukaryotic cells. Onnamide A and its analogues have attracted academic interest due to their cytotoxicity and potential for combating the growth and proliferation of cancer cells. History Onnamide A was first isolated in 1988 from ''Theonella spp.,'' a genus of marine sponges residing off the coast of Okinawa, Japan, as part of a bioassay aimed at discovering novel marine natural products possessing antiviral activity. Eight analogues possessing similar structure, as well as cytotoxicity were reported in 1992. Structure Onnamide A is a complex biomolecule with a 39 unique carbon atoms and 11 degrees of unsaturation. Its core contains ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pederin
Pederin is a vesicant toxic amide with two tetrahydropyran rings, found in the haemolymph of the beetle genus ''Paederus'', including the Nairobi fly, belonging to the family Staphylinidae. It was first characterized by processing 25 million field-collected ''P. fuscipes''.Bugs Don’t Have to Bite to Do Damage:The Tale of the Paederus Beetle It makes up approximately 0.025% of an insects weight (for ''P. fuscipes''). It has been demonstrated that the production of pederin relies on the activities of an ('' |
