|
Neil Kelleher (scientist)
Neil L. Kelleher is the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine at Northwestern University. His research focuses on mass spectrometry, primarily its application to proteomics. He is known mainly for top-down proteomics and the development of the fragmentation technique of electron-capture dissociation with Roman Zubarev while in Fred McLafferty's lab at Cornell University. Early life and education * B.S. Pacific Lutheran University * M.S. and Ph.D. Cornell University Research interests * Mass spectrometry * Electron-capture dissociation * Proteomics ** Top-down proteomics Awards * Biemann Medal, 2009 * Pittsburgh Conference Achievement Award, 2008 * Pfizer Award in Enzyme Chemistry (American Chemical Society, Division of Biological Chemistry), 2006 * A.F. Findeis Award in Measurement Science (American Chemical Society, Division of Analytical Chemistry), 2006 * Beckman Fellow A Beckman Fellow receives funding, usually via an in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometry
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio. These spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical identity or structure of molecules and other chemical compounds. In a typical MS procedure, a sample, which may be solid, liquid, or gaseous, is ionized, for example by bombarding it with a beam of electrons. This may cause some of the sample's molecules to break up into positively charged fragments or simply become positively charged without fragmenting. These ions (fragments) are then separated accordin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometrists
Mass is an intrinsic property of a body. It was traditionally believed to be related to the quantity of matter in a physical body, until the discovery of the atom and particle physics. It was found that different atoms and different elementary particles, theoretically with the same amount of matter, have nonetheless different masses. Mass in modern physics has multiple definitions which are conceptually distinct, but physically equivalent. Mass can be experimentally defined as a measure of the body's inertia, meaning the resistance to acceleration (change of velocity) when a net force is applied. The object's mass also determines the strength of its gravitational attraction to other bodies. The SI base unit of mass is the kilogram (kg). In physics, mass is not the same as weight, even though mass is often determined by measuring the object's weight using a spring scale, rather than balance scale comparing it directly with known masses. An object on the Moon would weigh l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Chemists
The 1st century was the century spanning AD 1 ( I) through AD 100 ( C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or historical period. The 1st century also saw the appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius ( AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and instability, which was finally brought to an end by Vespasian, ninth Roman em ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northwestern University Faculty
Northwestern or North-western or North western may refer to: * Northwest, a direction * Northwestern University, a private research university in Evanston, Illinois ** The Northwestern Wildcats, this school's intercollegiate athletic program ** Northwestern Medicine, an academic medical system comprising: *** Northwestern University Feinberg School of Medicine *** Northwestern Memorial Hospital. Other colleges and universities * Northwestern College (Iowa), a small Christian college in Iowa * University of Northwestern – St. Paul (formerly Northwestern College), a small Christian college, located in Roseville, Minnesota * The former Northwestern College in Watertown, Wisconsin, which was incorporated into Martin Luther College in New Ulm, Minnesota in 1995 * Northwestern Michigan College, a small college located in Traverse City, Michigan * Northwestern Oklahoma State University in Alva, Oklahoma * Northwestern State University, in Natchitoches, Louisiana * Northwestern Calif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University Alumni
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach and make contributions in all fields of knowledge—from the classics to the sciences, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's founding principle, a popular 1868 quotation from founder Ezra Cornell: "I would found an institution where any person can find instruction in any study." Cornell is ranked among the top global universities. The university is organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its specific admission standards and academic programs in near autonomy. The university also administers three satellite campuses, two in New York City and one in Education City, Qatar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pacific Lutheran University Alumni
The Pacific Ocean is the largest and deepest of Earth's five oceanic divisions. It extends from the Arctic Ocean in the north to the Southern Ocean (or, depending on definition, to Antarctica) in the south, and is bounded by the continents of Asia and Oceania in the west and the Americas in the east. At in area (as defined with a southern Antarctic border), this largest division of the World Ocean—and, in turn, the hydrosphere—covers about 46% of Earth's water surface and about 32% of its total surface area, larger than Earth's entire land area combined .Pacific Ocean . '' Britannica Concise.'' 2008: Encyclopædia Britannica, Inc. The centers of both the |
Beckman Fellow
A Beckman Fellow receives funding, usually via an intermediary institution, from the Arnold and Mabel Beckman Foundation, founded by Arnold Orville Beckman and his wife Mabel. The Foundation supports programs at several institutions to encourage research, particularly the work of young researchers who might not be eligible for other sources of funding. People from a variety of different programs at different institutions may therefore be referred to as Beckman Fellows. Though most often designating postdoctoral awards in science, the exact significance of the term will vary depending on the institution involved and the type(s) of Beckman Fellowship awarded at that institution. Arnold and Mabel Beckman Foundation Arnold O. Beckman Postdoctoral Fellowships The Arnold O. Beckman Postdoctoral Fellowship program was sponsored by the Arnold and Mabel Beckman Foundation to support research at US institutions in the biological and chemical sciences. A total of sixty Fellowships were a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer Award In Enzyme Chemistry
The Pfizer Award in Enzyme Chemistry, formerly known as the Paul-Lewis Award in Enzyme Chemistry was established in 1945. Consisting of a gold medal and honorarium, its purpose is to stimulate fundamental research in enzyme chemistry by scientists not over forty years of age. The award is administered by the Division of Biological Chemistry of the American Chemical Society and sponsored by Pfizer. The award was terminated in 2022. Recipients Source: http://www.divbiolchem.org/awards/recipients/ ACS-Division of Biological Chemistry *1946 – David E. Green *1947 – Van R. Potter *1948 – Albert L. Lehninger *1949 – Henry A. Lardy *1950 – Britton Chance *1951 – Arthur Kornberg *1952 – Bernard L. Horecker *1953 – Earl R. Stadtman *1954 – Alton Meister *1955 – Paul D. Boyer *1956 – Merton F. Utter *1957 – G. Robert Greenberg *1958 – Eugene P. Kennedy *1959 – Minor J. Coon *1960 †... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roman Zubarev
Roman A. Zubarev is a professor of medicinal proteomics in the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet. His research focuses on the use of mass spectrometry in biology and medicine. Early life and education * M.S. in applied physics at Moscow Engineering Physics Institute, 1986 * Ph.D. in ion physics at Uppsala University, 1997 Research interests * Electron-capture dissociation. In 1997, while in Fred McLafferty's lab at Cornell University, Zubarev discovered the phenomenon of electron-capture dissociation (ECD) of polypeptides. He later developed ECD and other ion-electron reactions2 as analytical techniques in Odense (1998 –2002) and Uppsala (2002 –2008). * Isotopic resonance hypothesis. Discovered the phenomenon of isotopic resonance in Uppsala (2008), formulated the isotopic resonance hypothesis and experimentally verified it in Stockholm (2009 –2013). * Isoaspartate theory of Alzheimer’s disease. The role of isoaspartate in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron-capture Dissociation
Electron-capture dissociation (ECD) is a method of fragmenting gas-phase ions for structure elucidation of peptides and proteins in tandem mass spectrometry. It is one of the most widely used techniques for activation and dissociation of mass selected precursor ion in MS/MS. It involves the direct introduction of low-energy electrons to trapped gas-phase ions. History Electron-capture dissociation was developed by Roman Zubarev and Neil Kelleher while in Fred McLafferty's lab at Cornell University. Irradiation of melittin 4+ ions and ubiquitin 10+ ions (trapped in FT-MS cell) by laser pulses not only resulted in peculiar c', z fragmentation but also charge reduction. It was suggested that if FT cell is modified to trap cations and electrons simultaneously, secondary electrons emitted by UV photons increases the charge reduction effect and c′, z• fragmentation. Replacing UV laser with EI source led to the development of this new technique. Principles Electron-capture diss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Mass Spectrometry")
.jpg "Click for more on -> Pacific Lutheran University Alumni")
.jpg "Click for more on -> Proteomics")
