NeuroGrid
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NeuroGrid
Neurogrid is a piece of computer hardware that is designed specifically for simulation of biological brains. It uses analog computation to emulate ion channel activity, and digital communication to softwire structured connectivity patterns. Neurogrid simulates one million neurons and six billion synapses in real time. The neurons spike at a rate of ten times a second. In terms of number of simulated neurons, it rivals simulations done by the Blue Brain Project. However, by running the simulation of whole neurons, instead of simulation on molecular level, it needs only one millionth of Blue Brain's power. The entire board consumes less than two watts of electrical energy. Neurogrid was designed and built by the ''Brains in Silicon'' group at Stanford University. The group is led by Kwabena Boahen. The Neurogrid hardware was first up and running in late 2009. Since then it has been used to start performing simulation experiments. The Neurogrid board contains sixteen ''Neurocores'', ...
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Kwabena Boahen
Kwabena Adu Boahen is a Professor of Bioengineering and Electrical Engineering at Stanford University. He previously taught at the University of Pennsylvania. Education and early life Kwabena Boahen was born on September 22, 1964, in Accra, Ghana. He attended secondary school at Mfantsipim School in Cape Coast, Ghana, and at the Presbyterian Boys' Senior High School in Accra, Ghana. While at Mfantsipim, he invented a corn-planting machine that won the national science competition and graduated as the valedictorian of the Class of 1981. He received his B.S. and M.S. in electrical engineering in 1989 from Johns Hopkins University and his PhD in computation and neural systems in 1997 from the California Institute of Technology, where he was advised by Carver Mead. For his PhD thesis, Boahen designed and fabricated a silicon chip emulating the functioning of the retina. Boahen's father, Albert Adu Boahen, was a professor of history at the University of Ghana and an advocate for democ ...
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CoDi
CoDi is a cellular automaton (CA) model for spiking neural networks (SNNs). CoDi is an acronym for Collect and Distribute, referring to the signals and spikes in a neural network. CoDi uses a von Neumann neighborhood modified for a three-dimensional space; each cell looks at the states of its six orthogonal neighbors and its own state. In a growth phase a neural network is grown in the CA-space based on an underlying chromosome. There are four types of cells: neuron body, axon, dendrite and blank. The growth phase is followed by a signaling- or processing-phase. Signals are distributed from the neuron bodies via their axon tree and collected from connection dendrites. These two basic interactions cover every case, and they can be expressed simply, using a small number of rules. Cell interaction during signaling The neuron body cells collect neural signals from the surrounding dendritic cells and apply an internally defined function to the collected data. In the CoDi model ...
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Computer Hardware
Computer hardware includes the physical parts of a computer, such as the computer case, case, central processing unit (CPU), Random-access memory, random access memory (RAM), Computer monitor, monitor, Computer mouse, mouse, Computer keyboard, keyboard, computer data storage, graphics card, sound card, Computer speakers, speakers and motherboard. By contrast, software is the set of instructions that can be stored and run by hardware. Hardware is so-termed because it is "Hardness, hard" or rigid with respect to changes, whereas software is "soft" because it is easy to change. Hardware is typically directed by the software to execute any command or Instruction (computing), instruction. A combination of hardware and software forms a usable computing system, although Digital electronics, other systems exist with only hardware. Von Neumann architecture The template for all modern computers is the Von Neumann architecture, detailed in a First Draft of a Report on the EDVAC, 1945 ...
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Brain Simulation
Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. Various simulations from around the world have been fully or partially released as open source software, such as C. elegans,C. Elegans simulation
Open source software project at Github
and the Blue Brain Project Showcase. In 2013 the , which has utilized techniques used by the Blue Brain Project and built upon them,Human Brain Project, Framework Partnershi ...
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Analog Computer
An analog computer or analogue computer is a type of computer that uses the continuous variation aspect of physical phenomena such as electrical, mechanical, or hydraulic quantities (''analog signals'') to model the problem being solved. In contrast, digital computers represent varying quantities symbolically and by discrete values of both time and amplitude (digital signals). Analog computers can have a very wide range of complexity. Slide rules and nomograms are the simplest, while naval gunfire control computers and large hybrid digital/analog computers were among the most complicated. Complex mechanisms for process control and protective relays used analog computation to perform control and protective functions. Analog computers were widely used in scientific and industrial applications even after the advent of digital computers, because at the time they were typically much faster, but they started to become obsolete as early as the 1950s and 1960s, although they remaine ...
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Ion Channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters. The study of ion channels often involves biophysics, electrophysiology, and pharmacology, while using techniques including voltage clamp, patch clamp, immunohistochemistry, X-ray crystallography, fluoroscopy, and RT-PCR. Their classification as molecules is referred to as channelomics. Basic features There are two distinctive features of ion channels that differentiate them from other types of ion transporter proteins: #The rate of ion transport through the ...
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Neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body (soma), dendrites, and a single axon. The soma is a compact structure, and the axon and dend ...
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Synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from one neuron to another. Neurons are specialized to pass signals to individual target cells, and synapses are the means by which they do so. At a synapse, the plasma membrane of the signal-passing neuron (the ''presynaptic'' neuron) comes into close apposition with the membrane of the target (''postsynaptic'') cell. Both the presynaptic and postsynaptic sites contain extensive arrays of molecular machinery that link the two membranes together and carry out the signaling process. In many synapses, the presynaptic part is located on an axon and the postsynaptic part is located on a dendrite or soma. Astrocytes also exchange information with the synaptic neurons, responding to synaptic activity and, in turn, regulating neurotransmission. Syna ...
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Blue Brain
The Blue Brain Project is a Swiss brain research initiative that aims to create a digital reconstruction of the mouse brain. The project was founded in May 2005 by the Brain and Mind Institute of ''École Polytechnique Fédérale de Lausanne'' (EPFL) in Switzerland. Its mission is to use biologically-detailed digital reconstructions and simulations of the mammalian brain to identify the fundamental principles of brain structure and function. The project is headed by the founding director Henry Markram—who also launched the European Human Brain Project—and is co-directed by Felix Schürmann, Adriana Salvatore and Sean Hill. Using a Blue Gene supercomputer running Michael Hines's NEURON, the simulation involves a biologically realistic model of neurons and an empirically reconstructed model connectome. There are a number of collaborations, including the Cajal Blue Brain, which is coordinated by the Supercomputing and Visualization Center of Madrid (CeSViMa), and others run by ...
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Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneu ...
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Random-access Memory
Random-access memory (RAM; ) is a form of computer memory that can be read and changed in any order, typically used to store working Data (computing), data and machine code. A Random access, random-access memory device allows data items to be read (computer), read or written in almost the same amount of time irrespective of the physical location of data inside the memory, in contrast with other direct-access data storage media (such as hard disks, CD-RWs, DVD-RWs and the older Magnetic tape data storage, magnetic tapes and drum memory), where the time required to read and write data items varies significantly depending on their physical locations on the recording medium, due to mechanical limitations such as media rotation speeds and arm movement. RAM contains multiplexer, multiplexing and demultiplexing circuitry, to connect the data lines to the addressed storage for reading or writing the entry. Usually more than one bit of storage is accessed by the same address, and RAM ...
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