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Network Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error. The aim then is to use approaches from statistics to derive a pooled estimate closest to the unknown common truth based on how this error is perceived. Meta-analytic results are considered the most trustworthy source of evidence by the evidence-based medicine literature.Herrera Ortiz AF., Cadavid Camacho E, Cubillos Rojas J, Cadavid Camacho T, Zoe Guevara S, Tatiana Rincón Cuenca N, Vásquez Perdomo A, Del Castillo Herazo V, & Giraldo Malo R. A Practical Guide to Perform a Systematic Literature Review and Meta-analysis. Principles and Practice of Clinical Research. 2022;7(4):47–57. https://doi.org/10.21801/ppcrj.2021.74.6 Not only can meta-analyses provide an estimate of the unk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integrated Molecular Meta-Analysis Of 1,000 Pediatric High-Grade And Diffuse Intrinsic Pontine Glioma - Graphical Abstract
Integration may refer to: Biology *Multisensory integration *Path integration * Pre-integration complex, viral genetic material used to insert a viral genome into a host genome *DNA integration, by means of site-specific recombinase technology, performed by a specific class of recombinase enzymes ("integrases") Economics and law *Economic integration, trade unification between different states *Horizontal integration and vertical integration, in microeconomics and strategic management, styles of ownership and control *Regional integration, in which states cooperate through regional institutions and rules *Integration clause, a declaration that a contract is the final and complete understanding of the parties *A step in the process of money laundering *Integrated farming, a farm management system * Integration (tax), a feature of corporate and personal income tax in some countries Engineering *Data integration * Digital integration *Enterprise integration *Integrated architec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene V
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gene– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preferred Reporting Items For Systematic Reviews And Meta-Analyses
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is an evidence-based minimum set of items aimed at helping scientific authors to report a wide array of systematic reviews and meta-analyses, primarily used to assess the benefits and harms of a health care intervention. PRISMA focuses on ways in which authors can ensure a transparent and complete reporting of this type of research. The PRISMA standard superseded the earlier QUOROM standard. It offers the replicability of a systematic literature review. Researchers have to figure out research objectives that answer the research question, states the keywords, a set of exclusion and inclusion criteria. In the review stage, relevant articles were searched, irrelevant ones are removed. Articles are analyzed according to some pre-defined categories. The PRISMA statement The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. PRISMA has mainly focused on sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meta-regression
Meta-regression is defined to be a meta-analysis that uses regression analysis to combine, compare, and synthesize research findings from multiple studies while adjusting for the effects of available covariates on a response variable. A meta-regression analysis aims to reconcile conflicting studies or corroborate consistent ones; a meta-regression analysis is therefore characterized by the collated studies and their corresponding data sets—whether the response variable is study-level (or equivalently ''aggregate'') data or individual participant data (or individual patient data in medicine). A data set is ''aggregate'' when it consists of summary statistics such as the sample mean, effect size, or odds ratio. On the other hand, individual participant data are in a sense ''raw'' in that all observations are reported with no abridgment and therefore no information loss. Aggregate data are easily compiled through internet search engines and therefore not expensive. However, individu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Study Heterogeneity
In statistics, (between-) study heterogeneity is a phenomenon that commonly occurs when attempting to undertake a meta-analysis. In a simplistic scenario, studies whose results are to be combined in the meta-analysis would all be undertaken in the same way and to the same experimental protocols. Differences between outcomes would only be due to measurement error (and studies would hence be ''Homogeneity (statistics), homogeneous''). Study heterogeneity denotes the variability (statistics), variability in outcomes that goes beyond what would be expected (or could be explained) due to measurement error alone. Introduction Meta-analysis is a method used to combine the results of different trials in order to obtain a quantitative synthesis. The size of individual clinical trials is often too small to detect treatment effects reliably. Meta-analysis increases the power of statistical analyses by pooling the results of all available trials. As one tries to use meta-analysis to estimate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Effect Size
In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity. It can refer to the value of a statistic calculated from a sample of data, the value of a parameter for a hypothetical population, or to the equation that operationalizes how statistics or parameters lead to the effect size value. Examples of effect sizes include the correlation between two variables, the regression coefficient in a regression, the mean difference, or the risk of a particular event (such as a heart attack) happening. Effect sizes complement statistical hypothesis testing, and play an important role in power analyses, sample size planning, and in meta-analyses. The cluster of data-analysis methods concerning effect sizes is referred to as estimation statistics. Effect size is an essential component when evaluating the strength of a statistical claim, and it is the first item (magnitude) in the MAGI ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jessica Gurevitch
Jessica Gurevitch is plant ecologist known for meta-analysis in the fields of ecology and evolution. Education and career Gurevitch has a B.S. from Cornell University (1973) and earned her Ph.D. in ecology and evolutionary biology from the University of Arizona in 1982. She was a postdoctoral fellow for two years at the University of Chicago before moving to the State University of New York at Stony Brook in 1985. For two years starting in 1992, Guervitch worked at the National Science Foundation before returning to Stony Brook where she was promoted to professor in 2000. From 2015 to 2016, Gurevitch was president of the Society for Research Synthesis Methodology. Research Gurevitch's research interests are centered on biological invasions and meta-analysis in ecology. Her research on grasses perennial plants, and trees relied on a combination of experimental manipulations and observation data. Her interest in biological invasions includes investigations into the invasive flo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank L
Frank or Franks may refer to: People * Frank (given name) * Frank (surname) * Franks (surname) * Franks, a medieval Germanic people * Frank, a term in the Muslim world for all western Europeans, particularly during the Crusades - see Farang Currency * Liechtenstein franc or frank, the currency of Liechtenstein since 1920 * Swiss franc or frank, the currency of Switzerland since 1850 * Westphalian frank, currency of the Kingdom of Westphalia between 1808 and 1813 * The currencies of the German-speaking cantons of Switzerland (1803–1814): ** Appenzell frank ** Argovia frank ** Basel frank ** Berne frank ** Fribourg frank ** Glarus frank ** Graubünden frank ** Luzern frank ** Schaffhausen frank ** Schwyz frank ** Solothurn frank ** St. Gallen frank ** Thurgau frank ** Unterwalden frank ** Uri frank ** Zürich frank Places * Frank, Alberta, Canada, an urban community, formerly a village * Franks, Illinois, United States, an unincorporated community * Franks, Missouri, Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Rosenthal (psychologist)
Robert Rosenthal (born March 2, 1933) is a German-born American psychologist who is a Distinguished Professor of Psychology at the University of California, Riverside. His interests include self-fulfilling prophecies, which he explored in a well-known study of the Pygmalion effect: the effect of teachers' expectations on students. Biography Rosenthal was born in Gießen, Hesse, on March 2, 1933, and left Germany with his family at the age of six. In 1956, he was awarded a PhD by the University of California, Los Angeles. He started his career as a clinical psychologist and then moved into social psychology. From 1962 to 1999 he taught at Harvard, became chairman of the psychology department there in 1992, and Edgar Pierce Professor of Psychology in 1995. On retiring from Harvard in 1999, he went to California. Much of his work has focused on nonverbal communication, particularly its influence on expectations: for example, in doctor-patient or manager-employee situations. The ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas C
Thomas may refer to: People * List of people with given name Thomas * Thomas (name) * Thomas (surname) * Saint Thomas (other) * Thomas Aquinas (1225–1274) Italian Dominican friar, philosopher, and Doctor of the Church * Thomas the Apostle * Thomas (bishop of the East Angles) (fl. 640s–650s), medieval Bishop of the East Angles * Thomas (Archdeacon of Barnstaple) (fl. 1203), Archdeacon of Barnstaple * Thomas, Count of Perche (1195–1217), Count of Perche * Thomas (bishop of Finland) (1248), first known Bishop of Finland * Thomas, Earl of Mar (1330–1377), 14th-century Earl, Aberdeen, Scotland Geography Places in the United States * Thomas, Illinois * Thomas, Indiana * Thomas, Oklahoma * Thomas, Oregon * Thomas, South Dakota * Thomas, Virginia * Thomas, Washington * Thomas, West Virginia * Thomas County (other) * Thomas Township (other) Elsewhere * Thomas Glacier (Greenland) Arts, entertainment, and media * ''Thomas'' (Burton novel) 1969 novel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacob Cohen (born 1923)
Jacob Cohen (April 20, 1923 – January 20, 1998) was an American psychologist and statistician best known for his work on statistical power and effect size, which helped to lay foundations for current statistical meta-analysis and the methods of estimation statistics. He gave his name to such measures as Cohen's kappa, Cohen's ''d'', and Cohen's ''h''. Power analysis and significance testing In addition to being an advocate of power analysis and effect size, Cohen was a critic of reliance on, and lack of understanding of, significance testing procedures used in statistics, especially misunderstandings of null hypothesis significance testing. In particular, he identified the "near universal misinterpretation of p as the probability that H0 is false, the misinterpretation that its complement is the probability of successful replication, and the mistaken assumption that if one rejects H0 one thereby affirms the theory that led to the test". He encouraged instead a recognition of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John E
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
