|
Negri Bodies
Negri bodies are eosinophilic, sharply outlined, pathognomonic inclusion bodies (2–10 μm in diameter) found in the cytoplasm of certain nerve cells containing the virus of rabies, especially in pyramidal cells within Ammon's horn of the hippocampus. They are also often found in the Purkinje cells of the cerebellar cortex from postmortem brain samples of rabies victims. They consist of ribonuclear proteins produced by the virus. They are named for Adelchi Negri. History and use as a Rabies Diagnosis Adelchi Negri, an assistant pathologist working in the laboratory of Camillo Golgi, observed these inclusions in rabbits and dogs with rabies. These findings were presented in 1903 at a meeting of the Società Medico-Chirurgica of Pavia. The American pathologist Anna Wessels Williams made the same discovery, but because Negri published his results first, the bodies bear his name. Negri was convinced the inclusions were a parasitic protozoon and the etiologic agent of ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histopathology Of Negri Bodies In Rabies Encephalitis
Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία ''-logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks"). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adelchi Negri
Adelchi Negri (16 July 1876 – 19 February 1912) was an Italian pathologist and microbiologist born in Perugia. He studied medicine and surgery at the University of Pavia, where he was a pupil of Camillo Golgi (1843–1926). After graduation in 1900, he became an assistant to Golgi at his pathological institute. In 1909 Negri became a professor of bacteriology, and the first official instructor of bacteriology in Pavia. On 19 February 1912 he died of tuberculosis at age 35. Negri performed extensive research in the fields of histology, hematology, cell biology, cytology, protozoology and hygiene. In 1903 he discovered the eponymous Negri bodies, defined as cytoplasmatic inclusion bodies located in the Purkinje cells of the cerebellum in cases of rabies in animals and humans. He documented his findings in an article titled ''Contributo allo studio dell'eziologia della rabbia'', published in the journal ''Bollettino della Società medico-chirurgica''. At the time, Negri mistakenly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabies
Rabies is a viral disease that causes encephalitis in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: nausea, vomiting, violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is virtually always death, regardless of treatment. The time period between contracting the disease and the start of symptoms is usually one to three months but can vary from less than one week to more than one year. The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system. Rabies is caused by lyssaviruses, including the rabies virus and Australian bat lyssavirus. It is spread when an infected animal bites or scratches a human or other animals. Saliva from an infected animal can also transmit rabies if the saliva come ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histopathology
Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία '' -logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks"). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898,Dimmock p. 4 more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or ''virions'', consisting of (i) the genetic material, i. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naples
Naples (; it, Napoli ; nap, Napule ), from grc, Νεάπολις, Neápolis, lit=new city. is the regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 909,048 within the city's administrative limits as of 2022. Its province-level municipality is the third-most populous metropolitan city in Italy with a population of 3,115,320 residents, and its metropolitan area stretches beyond the boundaries of the city wall for approximately 20 miles. Founded by Greeks in the first millennium BC, Naples is one of the oldest continuously inhabited urban areas in the world. In the eighth century BC, a colony known as Parthenope ( grc, Παρθενόπη) was established on the Pizzofalcone hill. In the sixth century BC, it was refounded as Neápolis. The city was an important part of Magna Graecia, played a major role in the merging of Greek and Roman society, and was a significant cultural centre under the Romans. Naples served a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfonso Di Vestea
Alphons (Latinized ''Alphonsus'', ''Adelphonsus'', or ''Adefonsus'') is a male given name recorded from the 8th century (Alfonso I of Asturias, r. 739–757) in the Christian successor states of the Visigothic kingdom in the Iberian peninsula. In the later medieval period it became a standard name in the Hispanic and Portuguese royal families. It is derived from a Gothic name, or a conflation of several Gothic names; from ''*Aþalfuns'', composed of the elements ''aþal'' "noble" and ''funs'' "eager, brave, ready", and perhaps influenced by names such as ''*Alafuns'', ''*Adefuns'' and ''* Hildefuns''. It is recorded as ''Adefonsus'' in the 9th and 10th century, and as ''Adelfonsus'', ''Adelphonsus'' in the 10th to 11th. The reduced form ''Alfonso'' is recorded in the late 9th century, and the Portuguese form ''Afonso'' from the early 11th. and ''Anfós'' in Catalan from the 12th Century until the 15th. Variants of the name include: ''Alonso'' (Spanish), ''Alfonso'' (Spanish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Constantinople
la, Constantinopolis ota, قسطنطينيه , alternate_name = Byzantion (earlier Greek name), Nova Roma ("New Rome"), Miklagard/Miklagarth (Old Norse), Tsargrad ( Slavic), Qustantiniya (Arabic), Basileuousa ("Queen of Cities"), Megalopolis ("the Great City"), Πόλις ("the City"), Kostantiniyye or Konstantinopolis ( Turkish) , image = Byzantine Constantinople-en.png , alt = , caption = Map of Constantinople in the Byzantine period, corresponding to the modern-day Fatih district of Istanbul , map_type = Istanbul#Turkey Marmara#Turkey , map_alt = A map of Byzantine Istanbul. , map_size = 275 , map_caption = Constantinople was founded on the former site of the Greek colony of Byzantion, which today is known as Istanbul in Turkey. , coordinates = , location = Fatih, İstanbul, Turkey , region = Marmara Region , type = Imperial city , part_of = , length = , width ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Remlinger
Paul Remlinger (29 December 1871 – 9 March 1964) was a French physician and biologist born in Bertrange, Moselle. He studied medicine at the Val de Grâce military hospital, supporting his doctoral thesis in 1893 at the University of Lyon with a study on the heredity of tuberculosis. In 1896 he became head of the bacteriology laboratory in Tunis, followed by an assignment to the Constantinople Imperial Bacteriology Institute (1900). Soon afterwards he succeeded Maurice Nicolle (1862-1932) as director of the institute. In 1914 he relocated to Tangier, where he served at the newly founded Pasteur Institute. He would be associated with the Tangier institute until his retirement in 1957. During World War I he worked as a doctor at Argonne, where he performed research of bacillary dysentery with Julien Dumas (1884-1965). Remlinger was a leading authority on rabies and rabies vaccination. In 1903 he demonstrated that the causative agent of rabies was a filterable virus. He was a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cause (medicine)
Cause, also known as etiology () and aetiology, is the reason or origination of something. The word ''etiology'' is derived from the Greek , ''aitiologia'', "giving a reason for" (, ''aitia'', "cause"; and , ''-logia''). Description In medicine, etiology refers to the cause or causes of diseases or pathologies. Where no etiology can be ascertained, the disorder is said to be idiopathic. Traditional accounts of the causes of disease may point to the "evil eye". The Ancient Roman scholar Marcus Terentius Varro put forward early ideas about microorganisms in a 1st-century BC book titled ''On Agriculture''. Medieval thinking on the etiology of disease showed the influence of Galen and of Hippocrates. Medieval European doctors generally held the view that disease was related to the air and adopted a miasmatic approach to disease etiology. Etiological discovery in medicine has a history in Robert Koch's demonstration that species of the pathogenic bacteria ''Mycobacterium tuberculosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protozoa
Protozoa (singular: protozoan or protozoon; alternative plural: protozoans) are a group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic tissues and debris. Historically, protozoans were regarded as "one-celled animals", because they often possess animal-like behaviours, such as motility and predation, and lack a cell wall, as found in plants and many algae. When first introduced by Georg Goldfuss (originally spelled Goldfuß) in 1818, the taxon Protozoa was erected as a class within the Animalia, with the word 'protozoa' meaning "first animals". In later classification schemes it was elevated to a variety of higher ranks, including phylum, subkingdom and kingdom, and sometimes included within Protoctista or Protista. The approach of classifying Protozoa within the context of Animalia was widespread in the 19th and early 20th century, but not universal. By the 1970s, it became usual to require th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
