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Mallinckrodt Institute Of Radiology
The Mallinckrodt Institute of Radiology (MIR), established 1931, is an academic radiology center associated with the Washington University School of Medicine, located within the Washington University Medical Center in St. Louis, Missouri. In addition to providing diagnostic and therapeutic patient-care services, the institute is a top research and education center. It employs over 140 academic staff and is among the top recipients of National Institutes of Health funding of radiology departments. The center provides radiology services to Barnes-Jewish and St. Louis Children's hospitals, as well as multiple other hospitals and outpatient centers in the St. Louis area. The center performs 700,000 examinations and procedures annually. Mallinckrodt has for decades been considered the premier radiology residency training program in the United States and has consistently been ranked among the top three radiology training programs in the country. In 2020, Doximity ranked the institute at ...
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Private School
Private or privates may refer to: Music * " In Private", by Dusty Springfield from the 1990 album ''Reputation'' * Private (band), a Denmark-based band * "Private" (Ryōko Hirosue song), from the 1999 album ''Private'', written and also recorded by Ringo Sheena * "Private" (Vera Blue song), from the 2017 album ''Perennial'' Literature * ''Private'' (novel), 2010 novel by James Patterson * ''Private'' (novel series), young-adult book series launched in 2006 Film and television * ''Private'' (film), 2004 Italian film * ''Private'' (web series), 2009 web series based on the novel series * ''Privates'' (TV series), 2013 BBC One TV series * Private, a penguin character in '' Madagascar'' Other uses * Private (rank), a military rank * ''Privates'' (video game), 2010 video game * Private (rocket), American multistage rocket * Private Media Group, Swedish adult entertainment production and distribution company * '' Private (magazine)'', flagship magazine of the Private Medi ...
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Mallinckrodt
Mallinckrodt Pharmaceuticals is an American-Irish domiciled manufacturer of specialty pharmaceuticals (namely, adrenocorticotropic hormone), generic drugs and imaging agents. In 2017 it generated 90% of its sales from the U.S. healthcare system. While Mallinckrodt is headquartered in Ireland for tax purposes, its operational headquarters are in the U.S. Mallinckrodt's 2013 tax inversion to Ireland drew controversy when it was shown Acthar was Medicaid's most expensive drug. Mallinckrodt acquires (for repricing), manufactures, and distributes products used in diagnostic procedures and in the treatment of pain and related conditions. This includes the acquisition, manufacture, and distribution of specialty pharmaceuticals, active pharmaceutical ingredients, contrast products, and radiopharmaceuticals. The company employed 5,500 and had net sales of $3.2 billion in 2017; of which $2.9 billion was from the U.S. healthcare system. The company has been implicated as a major contribu ...
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Marcus Raichle
Marcus E. Raichle (born March 15, 1937) is an American neurologist at the Washington University School of Medicine in Saint Louis, Missouri. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease. He received the Kavli Prize in Neuroscience “for the discovery of specialized brain networks for memory and cognition", together with Brenda Milner and John O’Keefe in 2014. Career Noteworthy accomplishments of Marcus Raichle include the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI; the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signatu ...
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Maximum Intensity Projection
In scientific visualization, a maximum intensity projection (MIP) is a method for 3D data that projects in the visualization plane the voxels with maximum intensity that fall in the way of parallel rays traced from the viewpoint to the plane of projection. This implies that two MIP renderings from opposite viewpoints are symmetrical images if they are rendered using orthographic projection. MIP is used for the detection of lung nodules in lung cancer screening programs which use computed tomography scans. MIP enhances the 3D nature of these nodules, making them stand out from pulmonary bronchi and vasculature. MIP imaging is also used routinely by physicians in interpreting Positron Emission Tomography (PET) or Magnetic Resonance Angiography studies. Additional techniques This technique is computationally fast, but the 2D results do not provide a good sense of depth of the original data. To improve the sense of 3D, animations are usually rendered of several MIP frames in w ...
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Jerold Wallis
Jerold is a given name. Notable people with the name include: * Jerold Hoffberger (1919–1999), American businessman * Jerold Ottley, music director of the Mormon Tabernacle Choir from 1974 to 1999 *Jerold Promes (born 1984), Dutch footballer who currently plays for Sparta Rotterdam *Jerold Starr (born 1941), American writer and professor best known as a national reformer of public broadcasting * Jerold T. Hevener (born 1873), American film actor and director *Jerold Wells Jerold Wells (8 August 1908 – 19 July 1999) was an English actor. He was born in Wallington, Hampshire, and died in Bath, Somerset. He appeared primarily in British comedies. Films included ''Adventures of a Plumber's Mate'' and the TV-made ...
(1908–1999), English actor {{given name ...
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Cobalt-60
Cobalt-60 (60Co) is a synthetic radioactive isotope of cobalt with a half-life of 5.2713 years. It is produced artificially in nuclear reactors. Deliberate industrial production depends on neutron activation of bulk samples of the monoisotopic and mononuclidic cobalt isotope . (PDF also located aCanadian Nuclear FAQ Measurable quantities are also produced as a by-product of typical nuclear power plant operation and may be detected externally when leaks occur. In the latter case (in the absence of added cobalt) the incidentally produced is largely the result of multiple stages of neutron activation of iron isotopes in the reactor's steel structures via the creation of its precursor. The simplest case of the latter would result from the activation of . undergoes beta decay to the stable isotope nickel-60 (). The activated nickel nucleus emits two gamma rays with energies of 1.17 and 1.33 MeV, hence the overall equation of the nuclear reaction (activation and decay) is: ...
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Carbon-14
Carbon-14, C-14, or radiocarbon, is a radioactive isotope of carbon with an atomic nucleus containing 6 protons and 8 neutrons. Its presence in organic materials is the basis of the radiocarbon dating method pioneered by Willard Libby and colleagues (1949) to date archaeological, geological and hydrogeological samples. Carbon-14 was discovered on February 27, 1940, by Martin Kamen and Sam Ruben at the University of California Radiation Laboratory in Berkeley, California. Its existence had been suggested by Franz Kurie in 1934. There are three naturally occurring isotopes of carbon on Earth: carbon-12 (), which makes up 99% of all carbon on Earth; carbon-13 (), which makes up 1%; and carbon-14 (), which occurs in trace amounts, making up about 1 or 1.5 atoms per 1012 atoms of carbon in the atmosphere. Carbon-12 and carbon-13 are both stable, while carbon-14 is unstable and has a half-life of 5,730 ± 40 years. Carbon-14 decays into nitrogen-14 () through beta decay. A gra ...
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Martin Kamen
Martin David Kamen (August 27, 1913, Toronto – August 31, 2002, Montecito, California) was an American chemist who, together with Sam Ruben, co-discovered the synthesis of the isotope carbon-14 on February 27, 1940, at the University of California Radiation Laboratory, Berkeley. He also confirmed that all of the oxygen released in photosynthesis comes from water, not carbon dioxide, in 1941. Kamen was the first to use carbon-14 to study a biochemical system, and his work revolutionized biochemistry and molecular biology, enabling scientists to trace a wide variety of biological reactions and processes. Despite being blacklisted for nearly a decade on suspicion of being a security risk, Kamen went on to receive the Albert Einstein World Award of Science in 1989, and the U.S. Department of Energy's 1995 Enrico Fermi award for lifetime scientific achievement. Early life and education Kamen was born on August 27, 1913, in Toronto, the son of Russian Jewish immigrants. ...
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Kymograph
A kymograph (from Greek κῦμα, swell or wave + γραφή, writing; also called a kymographion) is an analog device that draws a graphical representation of spatial position over time in which a spatial axis represents time. It basically consists of a revolving drum wrapped with a sheet of paper on which a stylus moves back and forth recording perceived changes of phenomena such as motion or pressure. The kymograph was initially a mechanical and hydraulic device, invented by German physiologist Carl Ludwig in the 1840s, and found its first use as a means to monitor blood pressure. The blood pressure was conveyed by hydraulics and levers to move a stylus that scratched a white trace into soot-covered paper on the revolving drum. Time is represented by the drum's rotation rate, and was recorded by a further stylus driven by a clock or tuning fork. The kymograph almost immediately became the central instrument in physiology and physiology education. Throughout the nineteenth a ...
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Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, -FDG is commonly used to detect cancer, NaF is widely used for detecting bone formation, and oxygen-15 is sometimes used to measure blood flow. PET is a common imaging technique, a medical scintillography technique used in nuclear medicine. A radiopharmaceutical — a radioisotope attached to a drug — is injected into the body as a tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is emitted, and when the positron collides with an ordinary electron, the two particles annihilate and gamma rays are emitted. These gamma rays are detecte ...
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Cyclotron
A cyclotron is a type of particle accelerator invented by Ernest O. Lawrence in 1929–1930 at the University of California, Berkeley, and patented in 1932. Lawrence, Ernest O. ''Method and apparatus for the acceleration of ions'', filed: January 26, 1932, granted: February 20, 1934 A cyclotron accelerates charged particles outwards from the center of a flat cylindrical vacuum chamber along a spiral path. The particles are held to a spiral trajectory by a static magnetic field and accelerated by a rapidly varying electric field. Lawrence was awarded the 1939 Nobel Prize in Physics for this invention. The cyclotron was the first "cyclical" accelerator. The primary accelerators before the development of the cyclotron were electrostatic accelerators, such as the Cockcroft–Walton accelerator and Van de Graaff generator. In these accelerators, particles would cross an accelerating electric field only once. Thus, the energy gained by the particles was limited by the maximum e ...
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Bile
Bile (from Latin ''bilis''), or gall, is a dark-green-to-yellowish-brown fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is produced continuously by the liver (liver bile) and stored and concentrated in the gallbladder. After eating, this stored bile is discharged into the duodenum. The composition of hepatic bile is (97–98)% water, 0.7% bile salts, 0.2% bilirubin, 0.51% fats (cholesterol, fatty acids, and lecithin), and 200 meq/L inorganic salts. The two main pigments of bile are bilirubin, which is yellow, and its oxidised form biliverdin, which is green. When mixed, they are responsible for the brown color of feces. About 400 to 800 millilitres of bile is produced per day in adult human beings. Function Bile or gall acts to some extent as a surfactant, helping to emulsify the lipids in food. Bile salt anions are hydrophilic on one side and hydrophobic on the other side; consequently, they tend t ...
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