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Mallinckrodt
Mallinckrodt Pharmaceuticals is an American-Irish domiciled manufacturer of specialty pharmaceuticals (namely, adrenocorticotropic hormone), generic drugs and imaging agents. In 2017 it generated 90% of its sales from the U.S. healthcare system. While Mallinckrodt is headquartered in Ireland for tax purposes, its operational headquarters are in the U.S. Mallinckrodt's 2013 tax inversion to Ireland drew controversy when it was shown Acthar was Medicaid's most expensive drug. Mallinckrodt acquires (for repricing), manufactures, and distributes products used in diagnostic procedures and in the treatment of pain and related conditions. This includes the acquisition, manufacture, and distribution of specialty pharmaceuticals, active pharmaceutical ingredients, contrast products, and radiopharmaceuticals. The company employed 5,500 and had net sales of $3.2 billion in 2017; of which $2.9 billion was from the U.S. healthcare system. The company has been implicated as a major contrib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward Mallinckrodt
Mallinckrodt Pharmaceuticals is an American-Irish domiciled manufacturer of specialty pharmaceuticals (namely, adrenocorticotropic hormone), generic drugs and imaging agents. In 2017 it generated 90% of its sales from the U.S. healthcare system. While Mallinckrodt is headquartered in Ireland for tax purposes, its operational headquarters are in the U.S. Mallinckrodt's 2013 tax inversion to Ireland drew controversy when it was shown Acthar was Medicaid's most expensive drug. Mallinckrodt acquires (for repricing), manufactures, and distributes products used in diagnostic procedures and in the treatment of pain and related conditions. This includes the acquisition, manufacture, and distribution of specialty pharmaceuticals, active pharmaceutical ingredients, contrast products, and radiopharmaceuticals. The company employed 5,500 and had net sales of $3.2 billion in 2017; of which $2.9 billion was from the U.S. healthcare system. The company has been implicated as a major contrib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenocorticotropic Hormone (medication)
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. The form that is purified from pig pituitary glands is known as corticotropin is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland. The form that is made synthetically is tetracosactide, also known as synacthen, tetracosactrin and cosyntropin. It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide. Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function. Medical uses Both corticotropin and tetracosactide have been used for diagnostic purposes to determine adrenocortical insufficiency, particularly in Addison's disease, via the ACTH stimulation test. However, as of 2015 the US label for corticotropin does not include diagnostic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project
The Manhattan Project was a research and development undertaking during World War II that produced the first nuclear weapons. It was led by the United States with the support of the United Kingdom and Canada. From 1942 to 1946, the project was under the direction of Major General Leslie Groves of the United States Army Corps of Engineers, U.S. Army Corps of Engineers. Nuclear physicist Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the actual bombs. The Army component of the project was designated the Manhattan District as its first headquarters were in Manhattan; the placename gradually superseded the official codename, Development of Substitute Materials, for the entire project. Along the way, the project absorbed its earlier British counterpart, Tube Alloys. The Manhattan Project began modestly in 1939, but grew to employ more than 130,000 people and cost nearly US$2 billion (equivalent to about $ billion in ). Over 90 percent of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tyco International
Tyco International plc was a security systems company incorporated in the Republic of Ireland, with operational headquarters in Princeton, New Jersey, United States (Tyco International (US) Inc.). Tyco International was composed of two major business segments: security solutions and fire protection. On January 25, 2016, Johnson Controls announced it would merge with Tyco, and all businesses of Tyco and Johnson Controls would be combined under Tyco International plc, to be renamed as Johnson Controls International plc. The merger was completed on September 9, 2016. Timeline 1960s Founded by Arthur J. Rosenberg in 1960, Tyco, Inc. was formed as an investment and holding company with two segments: Tyco Semiconductors and The Materials Research Laboratory. In the first two years of operation, the company focused primarily on governmental research and military experiments in the private sector. In 1962, the business was incorporated in Massachusetts and refocused on high-tech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coldwater Creek (Missouri River Tributary)
Coldwater Creek (also Cold Water Creek) is a 19-mile tributary of the Missouri River in north St. Louis County in the U.S. state of Missouri. It is known to be contaminated with radioactive wastes. Location The creek begins in a small spring-fed lake in Overland, then flows north through the towns of Breckenridge Hills, St. Ann and Bridgeton, before entering a culvert underneath Lambert International Airport. North of the airport, it flows northeast through the cities of Hazelwood, Berkeley, Florissant, Old Jamestown, Black Jack, and Spanish Lake. According to ''St. Louis Magazine'', "It runs past schools, golf courses, and soccer fields." The creek terminates in the Missouri River between the Lewis Bridge and the Columbia Bottom Conservation Area. History The name "Coldwater Creek" is a translation of the original French name ''Rivière de L'eau Froide''. The Spaniards called it Rio Fernando, Spanish for "Ferdinand River." The French also called it Riviere aux Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corporation Tax In The Republic Of Ireland
Ireland's Corporate Tax System is a central component of Ireland's economy. In 2016–17, foreign firms paid 80% of Irish corporate tax, employed 25% of the Irish labour force (paid 50% of Irish salary tax), and created 57% of Irish OECD non-farm value-add. As of 2017, 25 of the top 50 Irish firms were U.S.–controlled businesses, representing 70% of the revenue of the top 50 Irish firms. By 2018, Ireland had received the most U.S. in history, and Apple was over one–fifth of Irish GDP. Academics rank Ireland as the largest tax haven; larger than the Caribbean tax haven system. Ireland's "headline" corporation tax rate is 12.5%, however, foreign multinationals pay an aggregate of 2.2–4.5% on global profits "shifted" to Ireland, via Ireland's global network of bilateral tax treaties. These lower effective tax rates are achieved by a complex set of Irish base erosion and profit shifting ("BEPS") tools which handle the largest BEPS flows in the world (e.g. the Double Ir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metallurgical Laboratory
The Metallurgical Laboratory (or Met Lab) was a scientific laboratory at the University of Chicago that was established in February 1942 to study and use the newly discovered chemical element plutonium. It researched plutonium's chemistry and metallurgy, designed the world's first nuclear reactors to produce it, and developed chemical processes to separate it from other elements. In August 1942 the lab's chemical section was the first to chemically separate a weighable sample of plutonium, and on 2 December 1942, the Met Lab produced the first controlled nuclear chain reaction, in the reactor Chicago Pile-1, which was constructed under the stands of the university's old football stadium, Stagg Field. The Metallurgical Laboratory was established as part of the Metallurgical Project, also known as the "Pile" or "X-10" Project, headed by Chicago professor Arthur H. Compton, a Nobel Prize laureate. In turn, this was part of the Manhattan Project – the Allied effort to develop the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Minerals And Chemical Corporation
IMC Global (also known as International Minerals and Chemical Corporation and Imcera) was a mining and production company, formerly listed on the S&P MidCap 400. It was founded in 1909 as International Agricultural Corporation. In 2004, IMC Global merged with Cargill, Inc.'s crop nutrition division to form The Mosaic Company, a crop nutrition company. History IMC Global was incorporated as International Agricultural Corporation on June 14, 1909 by Walderman Schmidten in the state of New York. A native German, Schmidten moved to secure entire capital in mines from his home country; he was successful in doing so with the Kaliwerke Sollstedt Gewerkschaft. Phosphate and potash production facilities were acquired in Tennessee and Florida. Capital stock of the International Agricultural Corporation was originally fixed at $15 million in July 1909, but increased to $36 million by April 1911. As World War I broke out, demand for fertilizer declined while that for sulfuric acid skyrocketed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Holly Compton
Arthur Holly Compton (September 10, 1892 – March 15, 1962) was an American physicist who won the Nobel Prize in Physics in 1927 for his 1923 discovery of the Compton effect, which demonstrated the particle nature of electromagnetic radiation. It was a sensational discovery at the time: the wave nature of light had been well-demonstrated, but the idea that light had both wave and particle properties was not easily accepted. He is also known for his leadership over the Metallurgical Laboratory at the University of Chicago during the Manhattan Project, and served as chancellor of Washington University in St. Louis from 1945 to 1953. In 1919, Compton was awarded one of the first two National Research Council Fellowships that allowed students to study abroad. He chose to go to the University of Cambridge's Cavendish Laboratory in England, where he studied the scattering and absorption of gamma rays. Further research along these lines led to the discovery of the Compton ef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
St Louis
St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million, making it the largest metropolitan area in Missouri and the second-largest in Illinois. Before European settlement, the area was a regional center of Native American Mississippian culture. St. Louis was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. Maxent, Pierre Laclède and Auguste Chouteau, who named it for Louis IX of France. In 1764, following France's defeat in the Seven Years' War, the area was ceded to Spain. In 1800, it was retroceded to France, which sold it three years later to the United States as part of the Louisiana Purchase; the city was then the point of embarkation for the Corps of Discovery on the Lewis and Clark Expe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tax Inversion
A tax inversion or corporate tax inversion is a form of tax avoidance where a corporation restructures so that the current parent is replaced by a foreign parent, and the original parent company becomes a subsidiary of the foreign parent, thus moving its tax residence to the foreign country. Executives and operational headquarters can stay in the original country. The US definition requires that the original shareholders remain a majority control of the post-inverted company. The majority of the less than 100 material tax inversions recorded since 1993 have been of US corporations (85 inversions), seeking to pay less to the US corporate tax system. The only other jurisdiction to experience a material outflow of tax inversions was the United Kingdom from 2007 to 2010 (22 inversions); however, UK inversions largely ceased post the reform of the UK corporate tax code from 2009 to 2012. The first inversion was McDermott International in 1983. Reforms by US Congress in 2004 hal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Superfund
Superfund is a United States federal environmental remediation program established by the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The program is administered by the United States Environmental Protection Agency, Environmental Protection Agency (EPA). The program is designed to investigate and clean up sites contaminated with hazardous substances. Sites managed under this program are referred to as "Superfund" sites. There are 40,000 federal Superfund sites across the country, and approximately 1,300 of those sites have been listed on the National Priorities List (NPL). Sites on the NPL are considered the most highly contaminated and undergo longer-term remedial investigation and remedial action (cleanups). The EPA seeks to identify parties responsible for hazardous substances released to the environment (polluters) and either compel them to clean up the sites, or it may undertake the cleanup on its own using the Superfund (a trust ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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