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Matthew Rabinowitz
Matthew Rabinowitz (born 4 February 1973) is a South African entrepreneur and investor. He is the co-founder and executive chairman of Natera (NTRA), a clinical genetic testing company. He serves as executive chairman, board member, adviser and angel investor to several companies and non-profits in diagnostics, biotech, gene editing, preventative healthcare, machine learning and conservation. Rabinowitz has been a consulting professor in Aeronautics and Astronautics at Stanford University, Visiting Faculty in Genetics at Harvard Medical School, and his technologies have generated over 100 patents and peer-reviewed publications, including the genetics, reproductive and oncology journals, ''Science'' and the cover of ''Nature''. In 2006, he received the Scott Helt Memorial award from IEEE for his work in wireless communication and navigation. Early life and education Matthew Rabinowitz was born on 4 February 1973 in Johannesburg, South Africa. His parents, Bernard “Bokkie” R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johannesburg
Johannesburg ( , , ; Zulu and xh, eGoli ), colloquially known as Jozi, Joburg, or "The City of Gold", is the largest city in South Africa, classified as a megacity, and is one of the 100 largest urban areas in the world. According to Demographia, the Johannesburg–Pretoria urban area (combined because of strong transport links that make commuting feasible) is the 26th-largest in the world in terms of population, with 14,167,000 inhabitants. It is the provincial capital and largest city of Gauteng, which is the wealthiest province in South Africa. Johannesburg is the seat of the Constitutional Court, the highest court in South Africa. Most of the major South African companies and banks have their head offices in Johannesburg. The city is located in the mineral-rich Witwatersrand range of hills and is the centre of large-scale gold and diamond trade. The city was established in 1886 following the discovery of gold on what had been a farm. Due to the extremely large gold de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South Africa
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countries of Namibia, Botswana, and Zimbabwe; and to the east and northeast by Mozambique and Eswatini. It also completely enclaves the country Lesotho. It is the southernmost country on the mainland of the Old World, and the second-most populous country located entirely south of the equator, after Tanzania. South Africa is a biodiversity hotspot, with unique biomes, plant and animal life. With over 60 million people, the country is the world's 24th-most populous nation and covers an area of . South Africa has three capital cities, with the executive, judicial and legislative branches of government based in Pretoria, Bloemfontein, and Cape Town respectively. The largest city is Johannesburg. About 80% of the population are Black South Afri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natera
Natera, Inc. is a clinical genetic testing company based in Austin, Texas that specializes in non-invasive, cell-free DNA (cfDNA) testing technology, with a focus on women’s health, cancer, and organ health. Natera’s proprietary technology combines novel molecular biology techniques with a suite of bioinformatics software that allows detection down to a single molecule in a tube of blood. Natera operates CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in San Carlos, California and Austin, Texas. History Natera (previously Gene Security Network) was founded by Matthew Rabinowitz and Jonathan Sheena in 2004. Natera launched its first product, the Spectrum preimplantation genetic test, in 2009. In 2010, the company introduced the Anora miscarriage (POC) test. Natera's advanced carrier screening test, Horizon, launched in 2012. The following year, 2013, Natera launched the Panorama non-invasive prenatal test (NIPT). In July ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Editing
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site-specific locations. The basic mechanism involved in genetic manipulations through programmable nucleases is the recognition of target genomic loci and binding of effector DNA-binding domain (DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases ( FokI and Cas), and the repair of DSBs through homology-directed recombination (HDR) or non-homologous end joining (NHEJ). History Genome editing was pioneered in the 1990s, before the advent of the common current nuclease-based gene editing platforms, however, its use was limited by low efficiencies of editing. Genome editing with engineered nucleases, i.e. all three major classes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inkatha Freedom Party
The Inkatha Freedom Party ( zu, IQembu leNkatha yeNkululeko, IFP) is a right-wing political party in South Africa. The party has been led by Velenkosini Hlabisa since the party's 2019 National General Conference. Mangosuthu Buthelezi founded the party in 1975 and led it until 2019. The IFP is currently the fourth largest party in the National Assembly of South Africa, in 2014 yielding third place to the Economic Freedom Fighters, formed in 2013. Although registered as a national party, it has had only minor electoral success outside its home province of KwaZulu-Natal. Policies Policy proposals of the IFP include: * Devolution of power to provincial governments * Making the head of state and head of government posts separate, with a ceremonial figurehead as head of state. * Mixed-member proportional representation for the National Assembly. * Liberalisation of trade * Lower income taxes * More flexible labour laws * Autonomy for traditional African communities and their lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Redhill School (Johannesburg)
Redhill School is a private English medium co-educational multi-faith day school located in Morningside, Johannesburg, Gauteng, South Africa. The school's motto is 'Free to Build'.Redhill School website http://www.redhill.co.za/ It was founded in 1907 and has over a thousand pupils from pre-primary (3 years) to high school (grade 12) enrolled. The school is part of ISASA (the Independent Schools Association of Southern Africa) and matriculants write the South African IEB examinations. In 2018, the school also introduced the IB (International Baccalaureate The International Baccalaureate (IB), formerly known as the International Baccalaureate Organization (IBO), is a nonprofit foundation headquartered in Geneva, Switzerland, and founded in 1968. It offers four educational programmes: the IB D ...) Diploma Program as an optional parallel program to the IEB. The school is divided into a Redhill Early Learning Center, Redhill Preparatory School, Redhill Middle School an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of The Witwatersrand
The University of the Witwatersrand, Johannesburg (), is a multi-campus South African Public university, public research university situated in the northern areas of central Johannesburg. It is more commonly known as Wits University or Wits ( or ). The university has its roots in the mining industry, as do Johannesburg and the Witwatersrand in general. Founded in 1896 as the South African School of Mines in Kimberley, South Africa, Kimberley, it is the third oldest South African university in continuous operation. The university has an enrolment of 40,259 students as of 2018, of which approximately 20 percent live on campus in the university's 17 residences. 63 percent of the university's total enrolment is for Undergraduate education, undergraduate study, with 35 percent being Postgraduate education, postgraduate and the remaining 2 percent being Occasional Students. The 2017 Academic Ranking of World Universities (ARWU) places Wits University, with its overall score, as the h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning started after the idea was picked up in 1984 by the US government, the project formally launched in 1990, and was declared essentially complete on April 14, 2003, but included only about 85% of the genome. Level "complete genome" was achieved in May 2021, with a remaining only 0.3% bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the United States government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Noninvasive Prenatal Testing
Noninvasive prenatal testing (NIPT) is a method used to determine the risk for the fetus being born with certain chromosomal abnormalities, such as trisomy 21, trisomy 18 and trisomy 13. This testing analyzes small DNA fragments that circulate in the blood of a pregnant woman. Unlike most DNA found in the nucleus of a cell, these fragments are not found within the cells, instead they are free-floating, and so are called cell free fetal DNA (cffDNA). These fragments usually contain less than 200 DNA building blocks (base pairs) and arise when cells die, and their contents, including DNA, are released into the bloodstream. cffDNA derives from placental cells and is usually identical to fetal DNA. Analysis of cffDNA from placenta provides the opportunity for early detection of certain chromosomal abnormalities without harming the fetus. Background The use of ultrasound and biochemical markers to detect aneuploidies is usually done in the first and / or second trimester of pregnancy. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In-vitro Fertilization
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's ovulatory process, removing an ovum or ova (egg or eggs) from their ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy. IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
