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Mark Pallen
Mark J. Pallen is a research leader at the Quadram Institute and Professor of Microbial Genomics at the University of East Anglia. In recent years, he has been at the forefront of efforts to apply next-generation sequencing to problems in microbiology and ancient DNA research. Education Pallen was educated at Wallington High School. He completed an undergraduate degree in medical sciences at Fitzwilliam College, Cambridge and gained his medical qualification from the London Hospital Medical College. During the early 1990s, he gained an MD while working at St Bartholomew's Hospital Medical College. In the mid-1990s, he worked for a PhD under the supervision of Gordon Dougan at Imperial College. During this time, he captained the winning team from Imperial College in the TV quiz show University Challenge, while also writing a series of articles for the ''British Medical Journal'', introducing the medical profession to the Internet. Microbial genomics, metagenomics and bioinforma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carshalton
Carshalton () is a town, with a historic village centre, in south London, England, within the London Borough of Sutton. It is situated south-southwest of Charing Cross, in the valley of the River Wandle, one of the sources of which is Carshalton Ponds in the middle of the village. Prior to the creation of Greater London in 1965, Carshalton was in the administrative county of Surrey. Carshalton consists of a number of neighbourhoods. The main focal point, Carshalton Village, is visually scenic and picturesque. At its centre it has two adjoining ponds, which are overlooked by the Grade II listed All Saints Church on the south side and the Victorian Grove Park on the north side. The Grade II listed Honeywood Museum sits on the west side, a few yards from the water. There are a number of other listed buildings, as well as three conservation areas, including one in the village. In addition to Honeywood Museum, there are several other cultural features in Carshalton, including the Cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Warwick
The University of Warwick ( ; abbreviated as ''Warw.'' in post-nominal letters) is a public research university on the outskirts of Coventry between the West Midlands (county), West Midlands and Warwickshire, England. The university was founded in 1965 as part of a government initiative to expand higher education. The Warwick Business School was established in 1967, the Warwick Law School in 1968, WMG, University of Warwick, Warwick Manufacturing Group (WMG) in 1980, and Warwick Medical School in 2000. Warwick incorporated Coventry College of Education in 1979 and Horticulture Research International in 2004. Warwick is primarily based on a campus on the outskirts of Coventry, with a satellite campus in Wellesbourne and a central London base at the Shard. It is organised into three faculties—Arts, Science Engineering and Medicine, and Social Sciences—within which there are 32 departments. As of 2021, Warwick has around 29,534 full-time students and 2,691 academic and research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beijing Genomics Institute
BGI Group, formerly Beijing Genomics Institute, is a Chinese genomics company with headquarters in Yantian District, Shenzhen. The company was originally formed in 1999 as a genetics research center to participate in the Human Genome Project. It also sequences the genomes of other animals, plants and microorganisms. BGI has transformed from a small research institute, notable for decoding the DNA of pandas and rice plants, into a diversified company active in animal cloning, health testing, and contract research. BGI's earlier research was continued by the Beijing Institute of Genomics, Chinese Academy of Sciences. BGI Research, the group's nonprofit division, works with the Institute of Genomics and operates the China National GeneBank under a contract with the Chinese government. BGI Genomics, a subsidiary, was listed on the Shenzhen Stock Exchange in 2017. In 2021, details came to light about multiple controversies involving the BGI Group. These controversies include al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Torrent
Ion semiconductor sequencing is a method of DNA sequencing based on the detection of hydrogen ions that are released during the polymerization of DNA. This is a method of "sequencing by synthesis", during which a complementary strand is built based on the sequence of a template strand. A microwell containing a template DNA strand to be sequenced is flooded with a single species of deoxyribonucleotide triphosphate (dNTP). If the introduced dNTP is complementary to the leading template nucleotide, it is incorporated into the growing complementary strand. This causes the release of a hydrogen ion that triggers an ISFET ion sensor, which indicates that a reaction has occurred. If homopolymer repeats are present in the template sequence, multiple dNTP molecules will be incorporated in a single cycle. This leads to a corresponding number of released hydrogens and a proportionally higher electronic signal. This technology differs from other sequencing-by-synthesis technologies in tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H4 Outbreak
H4, H04, or H-4 may refer to: Science and mathematics * ATC code H04 ''Pancreatic hormones'', a subgroup of the Anatomical Therapeutic Chemical Classification System * Histamine H4 receptor, a human gene * Histone H4, a protein involved in the structure of chromatin in eukaryotic cells * Hydrogen-4 (H-4), an isotope of hydrogen * H4, a symmetry group in the fifth dimension. Technology * H-4 SOW, a precision-guided glide bomb used by the Pakistan Air Force * Halo 4, a video game created by 343 Industries for the Xbox 360 * Harrison Number Four, an 18th-century marine chronometer designed by John Harrison * Zoom H4 Handy Recorder, a handheld digital audio recorder * , level 4 heading markup for HTML Web pages, see HTML element#heading Transport Automobiles and roads * H4, a halogen headlamp bulb * H4, development name of the Hummer HX concept car * H-4, shorthand for a 4-cylinder horizontally-opposed or "flat four" engine (not to be confused with an actual H engine) * H4 Danst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crowdsourcing
Crowdsourcing involves a large group of dispersed participants contributing or producing goods or services—including ideas, votes, micro-tasks, and finances—for payment or as volunteers. Contemporary crowdsourcing often involves digital platforms to attract and divide work between participants to achieve a cumulative result. Crowdsourcing is not limited to online activity, however, and there are various historical examples of crowdsourcing. The word crowdsourcing is a portmanteau of "crowd" and " outsourcing". In contrast to outsourcing, crowdsourcing usually involves less specific and more public groups of participants. Advantages of using crowdsourcing include lowered costs, improved speed, improved quality, increased flexibility, and/or increased scalability of the work, as well as promoting diversity. Crowdsourcing methods include competitions, virtual labor markets, open online collaboration and data donation. Some forms of crowdsourcing, such as in "idea competiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Medical Journal
''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Originally called the ''British Medical Journal'', the title was officially shortened to ''BMJ'' in 1988, and then changed to ''The BMJ'' in 2014. The journal is published by BMJ Publishing Group Ltd, a subsidiary of the British Medical Association (BMA). The editor-in-chief of ''The BMJ'' is Kamran Abbasi, who was appointed in January 2022. History The journal began publishing on 3 October 1840 as the ''Provincial Medical and Surgical Journal'' and quickly attracted the attention of physicians around the world through its publication of high-impact original research articles and unique case reports. The ''BMJ''s first editors were P. Hennis Green, lecturer on the diseases of children at the Hunterian School of Medicine, who also was its f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Challenge
''University Challenge'' is a British television quiz programme which first aired in 1962. ''University Challenge'' aired for 913 episodes on ITV from 21 September 1962 to 31 December 1987, presented by quizmaster Bamber Gascoigne. The BBC revived the programme on 21 September 1994 with Jeremy Paxman as the quizmaster. Paxman will relinquish his role as host following the conclusion of the 52nd series in 2023, after which he will be succeeded by Amol Rajan. In October 2022, an ITV documentary, ''Paxman: Putting Up With Parkinson's'', revealed how the disease has impacted him and revealed that Paxman recorded his very last episode of ''University Challenge'' on 15 October 2022, which is to air sometime in 2023. The current title holders are Imperial College London, who won the 51st series on 4 April 2022. The show has always been produced by the same company (originally named Granada Television, renamed ITV Studios in 2009 and renamed again Lifted Entertainment in 2021), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wallington County Grammar School
Wallington County Grammar School (WCGS) is a selective state boys' grammar school with a coeducational Sixth Form located in the London Borough of Sutton. From 1968 to the mid-1990s the school was known as Wallington High School for Boys. One of a handful of grammar schools in the borough, it is consistently ranked as one of the top performing state schools in the country based on its GCSE and A-level results. History WCGS opened on 19 September 1927 on the 33rd birthday of its founding headmaster, W.T. Hutchins, with 71 pupils, half a mile from the current site. The building had a single storey, with a wooden extension. The school moved to its present site on Croydon Road in 1935. During the Second World War, WCGS was damaged by a V-2 bomb. All windows were blown out and the roof collapsed. WCGS continued to function, with teachers and students working to rebuild the structure. 52 old boys were killed in action. The 1950s to 1970s marked a period of expansion and develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ancient DNA
Ancient DNA (aDNA) is DNA isolated from ancient specimens. Due to degradation processes (including cross-linking, deamination and fragmentation) ancient DNA is more degraded in comparison with contemporary genetic material. Even under the best preservation conditions, there is an upper boundary of 0.4–1.5 million years for a sample to contain sufficient DNA for sequencing technologies. The oldest sample ever sequenced is estimated to be 1.65 million years old. Genetic material has been recovered from paleo/archaeological and historical skeletal material, mummified tissues, archival collections of non-frozen medical specimens, preserved plant remains, ice and from permafrost cores, marine and lake sediments and excavation dirt. On 7 December 2022, ''The New York Times'' reported that two-million year old genetic material was found in Greenland, and is currently considered the oldest DNA discovered so far. History of ancient DNA studies 1980s The first study of what would ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbiology
Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, protistology, mycology, immunology, and parasitology. Eukaryotic microorganisms possess membrane-bound organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include Bacteria and Archaea. Microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means. Microbiologists often rely on molecular biology tools such as DNA sequence based identification, for example the 16S rRNA gene sequence used for bacteria identification. Viruses have been variably classified as organisms, as they have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Next-generation Sequencing
Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged between 1994 and 1998 and have been commercially available since 2005. These technologies use miniaturized and parallelized platforms for sequencing of 1 million to 43 billion short reads (50 to 400 bases each) per instrument run. Many NGS platforms differ in engineering configurations and sequencing chemistry. They share the technical paradigm of massive parallel sequencing via spatially separated, clonally amplified DNA templates or single DNA molecules in a flow cytometry, flow cell. This design is very different from that of Sanger sequencing—also known as capillary sequencing or first-generation sequencing—which is based on electrophoretic separation of chain-termination products produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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