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Marc Feldmann
Sir Marc Feldmann, (born 2 December 1944), is an Australian-educated British immunologist. He is a professor at the University of Oxford and a senior research fellow at Somerville College, Oxford. Biography Feldmann was born 2 December 1944 in Lvov to a Jewish family who managed to get to France immediately postwar. He emigrated from France to Australia at age eight. After graduating with an MBBS degree from the University of Melbourne in 1967, he earned a Ph.D. in Immunology at the Walter and Eliza Hall Institute of Medical Research in 1972 with Sir Gustav Nossal.Feldmann, M. (2009) ''Translating molecular insights in autoimmunity into effective therapy.'' Annu. Rev. Immunol. 27: 1-27. He moved to London in the 1970s, working first with Avrion Mitchison at the Imperial Cancer Research Fund's Tumour Immunology Unit; in 1985 he moved to the Charing Cross Sunley Research Centre and the Kennedy Institute of Rheumatology (which joined with the Faculty of Medicine at Imper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lvov
Lviv ( uk, Львів) is the largest city in Western Ukraine, western Ukraine, and the List of cities in Ukraine, seventh-largest in Ukraine, with a population of . It serves as the administrative centre of Lviv Oblast and Lviv Raion, and is one of the main Ukrainian culture, cultural centres of Ukraine. It was named in honour of Leo I of Galicia, Leo, the eldest son of Daniel of Galicia, Daniel, King of Ruthenia. Lviv emerged as the centre of the historical regions of Red Ruthenia and Galicia (Eastern Europe), Galicia in the 14th century, superseding Halych, Chełm, Belz and Przemyśl. It was the capital of the Kingdom of Galicia–Volhynia from 1272 to 1349, when it was conquered by King Casimir III the Great of Poland. From 1434, it was the regional capital of the Ruthenian Voivodeship in the Crown of the Kingdom of Poland, Kingdom of Poland. In 1772, after the First Partition of Poland, the city became the capital of the Habsburg Kingdom of Galicia and Lodomeria. In 1918, f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Schering Prize
The Ernst Schering Prize is awarded annually by the Ernst Schering Foundation for especially outstanding basic research in the fields of medicine, biology or chemistry anywhere in the world. Established in 1991 by the Ernst Schering Research Foundation, and named after the German apothecary and industrialist, Ernst Christian Friedrich Schering, who founded the Schering Corporation, the prize is now worth €50,000. Recipients SourceSchering Foundation *1992 , (Center for Molecular Biology, University of Heidelberg, Germany) *1993 Christiane Nüsslein-Volhard, ( Max Planck Institute for Developmental Biology in Tübingen, Germany) *1994 Bert Vogelstein, (Oncology Center, Johns Hopkins University, Baltimore, Maryland, US) *1995 Yasutomi Nishizuka, (Kobe University, Japan) *1996 Judah Folkman, (Harvard Medical School, Harvard University, Boston, US) *1997 Johann Mulzer, (Institute for Organic Chemistry, University of Vienna, Austria) *1998 Ilme Schlichting, ( Max Planck Institute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crohn's Disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and fatigue. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer. While the precise causes of Crohn's disease (CD) are unknown, it is believed to be caused by a combination of environmental, immune, and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system defends the gastrointestinal tract, possibly targeting microbial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Etanercept
Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It has U.S. Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Tumor necrosis factor alpha (TNFα) is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha. Etanercept is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor-alpha. Second ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centocor
Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company. Subsidiaries * Actelion * Cilag AG * Janssen Biotech (formerly ''Centocor'') * Janssen Vaccines (formerly ''Crucell'') * Tibotec * Beijing Dabao Cosmetics Co., Ltd. History The ear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infliximab
Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behçet's disease. It is given by slow injection into a vein, typically at six- to eight-week intervals. Common side effects include infections, acute infusion reactions, and abdominal pain. Infliximab is a chimeric monoclonal antibody biologic. It seems to work by binding to and neutralizing TNF-α, preventing it from interacting with its receptors on the cell. TNF-α is a chemical messenger (cytokine) and a key part of the autoimmune reaction. Infliximab was originally developed in mice as a mouse antibody. Because humans have immune reactions to mouse proteins, the mouse common domains were replaced with similar human antibody domains. They are monoclonal antibodies and have identical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumor Necrosis Factor Alpha
Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. As an adipokine, TNF promotes insulin resistance, and is associated with obesity-induced type 2 diabetes. As a cytokine, TNF is used by the immune system for cell signaling. If macrophages (certain white blood cells) detect an infection, they release TNF to alert other immune system cells as part of an inflammatory response. TNF signaling occurs through two receptors: TNFR1 and TNFR2. TNFR1 is constituitively expressed on most cell types, whereas TNFR2 is restricted primarily to endothelial, epithelial, and subsets of immune cells. TNFR1 signaling tends to be pro-inflammatory and apoptotic, whereas TNFR2 signaling is anti-inflammatory and promotes cell proliferation. Suppression of TNFR1 signaling has been important for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ravinder N
Ravinder or Ravindra is an Indian given name. Notable people with this name include: * Ravinder Baliala, member of the Haryana Legislative Assembly * Ravinder Bhalla, American civil rights lawyer, and mayor of Hoboken, New Jersey * Ravinder Bhogal, restaurateur, food writer, and chef * Ravinder Bopara, cricketer * Ravinder Chadha, cricketer * Ravinder Dhallan, chairman and chief executive officer of Ravgen * Ravinder Goswami, professor at the department of endocrinology and metabolism at the All India Institute of Medical Sciences, Delhi * Ravinder Grewal, singer and actor * Ravinder K. Jain, physicist, and academic from the University of New Mexico *Ravinder Kapoor, film actor popularly known as Goga Kapoor * Ravinder Khatri, Greco-Roman wrestler * Ravinder Kumar, historian * Ravinder Kumar, Member of the Legislative Assembly of India * Ravinder Kumar, serial killer * Ravinder Kumar Dhir, Air Marshal * Ravinder Kumar Molhu, member of the 15th and the 16th Legislative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytokine
Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some overlap in the terminology). Cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avrion Mitchison
(Nicholas) Avrion Mitchison (born 5 May 1928) is a British zoologist and immunologist. Biography Mitchison was born in 1928, the son of the Labour politician Dick Mitchison (Baron Mitchison of Carradale in the County of Argyll, who died 1970) and his wife, the writer Naomi (née Haldane). His uncle was the biologist J.B.S. Haldane and his grandfather the physiologist John Scott Haldane. His elder brothers are the bacteriologist Denis Mitchison and the zoologist Murdoch Mitchison. His son is the cell biologist Tim Mitchison. He is married to Lorna Margaret Martin, daughter of Maj-Gen John Simson Stuart Martin, CSI. They have five children, Tim, Matthew, Mary, Hannah and Ellen. Two are cell biologists Tim Mitchison and Hannah M. Mitchison. He was educated at Leighton Park School and secured a Classics scholarship to Balliol College. He received his DPhil at New College, Oxford with Nobelist Sir Peter Medawar. This was followed by a long career as Professor of Zoology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gustav Nossal
Sir Gustav Victor Joseph Nossal (born 4 June 1931) is an Austrian-born Australian research biologist. He is famous for his contributions to the fields of antibody formation and immunological tolerance. Early life and education Nossal's family was from Vienna, Austria. He was born four weeks prematurely in Bad Ischl while his mother was on holiday. His family left their home town of Vienna for Australia in 1939 following Nazi Germany's annexation of Austria. As his father's grandparents were Jewish, he was also considered Jewish and at risk of being sent to concentration camps. In an interview with Adam Spencer, Nossal noted that his father was not a professing Jew but of Jewish ethnicity as he had been baptised a Roman Catholic as a child. Nossal remarked that his father "therefore thought that he would be somewhat protected from the Holocaust-type predicament. Of course, he hadn't properly read ''Mein Kampf''. It was all spelt out there: if your four grandparents were Jewish, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bachelor Of Medicine And Surgery
Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United Kingdom. The historical degree nomenclature states that they are two separate undergraduate degrees. In practice, however, they are usually combined as one and conferred together, and may also be awarded at graduate-level medical schools. It usually takes five to six years to complete this degree. Bachelor of Medicine (MB, also BM, BMed) is the primary medical degree awarded by medical schools in China and some medical schools in Australia and UK. It usually takes five years to complete. These medical graduates with an MB degree can still practice surgery. Both medical degrees are considered MD-equivalent in US universities and medical institutions. In North America, the equivalent medical degree is awarded as Doctor of Medicine (MD) or D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
