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Janssen Biotech, Inc., formerly Centocor Biotech, Inc., is a biotechnology company that was founded in Philadelphia
Philadelphia
in 1979 with an initial goal of developing new diagnostic assays using monoclonal antibody technology.

Contents

1 History 2 Products 3 References 4 External links

History[edit] In 1982 Centocor transitioned into a publicly traded company. Subsequently, the company moved to a larger facility in Malvern, Pennsylvania
Pennsylvania
(a northwest suburb of Philadelphia). In 1984, Centocor opened an overseas plant in Leiden, the Netherlands. In 1997, eighteen years after its foundation, Centocor achieved its first year of operating profitability.[citation needed] In 1998, Centocor sold its diagnostic division to Fujirebio, Inc..[1] In 1999, Centocor became a wholly owned subsidiary of Johnson & Johnson, the worldwide manufacturer and marketer of healthcare products. Since being acquired by Johnson and Johnson, Centocor has increased its annual sales from approximately $500 million to more than $2 billion. During the same period, research and development investment increased from $75 million to more than $300 million.[citation needed] In 2004 Centocor purchased a new manufacturing plant in St. Louis, Missouri, and is currently opening a new manufacturing facility in County Cork, Ireland. The Dutch plant has been expanded substantially with a $250 million investment in additional production facilities, which were opened in 2006.[citation needed] In 2007, Centocor broke new ground in advertising by releasing Innerstate, believed to be the first theatrically released documentary film both created and entirely funded by a drug company, to promote Remicade
Remicade
(Infliximab).[2] In 2008, Centocor, Inc. and Ortho Biotech Inc. merged to form Centocor Ortho Biotech Inc. In June 2010 Centocor Ortho Biotech acquired RespiVert, a privately held drug discovery company focused on developing small-molecule, inhaled therapies for the treatment of pulmonary diseases.[3] In June 2011 Centocor Ortho Biotech changed its name to Janssen Biotech, Inc. as part of a global effort to unite the Janssen Pharmaceutical Companies around the world under a common identity. In December 2014, the company announced it would co-develop MacroGenics cancer drug candidate (MGD011) which targets both CD19
CD19
and CD3 proteins in treating B-cell
B-cell
malignant tumours. This could net MacroGenics up to $700 million.[4] In January 2015, the company announced it will utilise Isis Pharmaceuticals' Rna-targeting technology to discover and develop antisense drugs targeting autoimmune disorders of the gastrointestinal tract, with the partnership potentially generating up to $835 million for Isis.[5] Products[edit] In 1984 Centocor developed their first product approved by the U.S. Food and Drug Administration (FDA) — a diagnostic test used to detect the rabies virus.[citation needed] In 1998 the company launched its top-selling monoclonal antibody Remicade
Remicade
(infliximab) for its first FDA approved indication in Crohn's Disease. Subsequently, Remicade's market has expanded with approvals for rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, and pediatric Crohn's disease. Remicade
Remicade
was approved for plaque psoriasis in September 2006. Centocor also markets ReoPro (abciximab), a biologic agent indicated as an adjunct to coronary angioplasty (PTCA). In 2009, the U.S. FDA approved Simponi, a human monoclonal antibody for treatment for arthritis, which was co-developed with Medarex, Inc.[6] References[edit]

^ Centocor reaches agreement to sell oncology diagnostics business, 1998 press release ^ Stephanie Saul. "Drug Gets a Cameo in a Film Backed by Its Maker", New York Times, February 21, 2007. https://www.nytimes.com/2007/02/21/business/media/21adco.html ^ Centocor Ortho Biotech Acquires RespiVert Archived 2010-06-05 at the Wayback Machine. News article from InfoGrok. ^ http://www.genengnews.com/gen-news-highlights/janssen-joins-macrogenics-in-up-to-700m-cancer-collaboration/81250728/ ^ http://www.genengnews.com/gen-news-highlights/janssen-isis-pharma-ink-up-to-835m-antisense-agreement/81250763/ ^ Marcial, Gene (4 May 2009). "Marcial: Medarex, a Bright Spot in Biotech". businessweek.com. Retrieved 24 Sep 2014. 

External links[edit]

US site Dutch site

v t e

Johnson & Johnson

CEOs and presidents

Current: Alex Gorsky, Chairman and CEO

Robert Wood Johnson I James Wood Johnson Robert Wood Johnson II Robert Wood Johnson III Philip B. Hofmann Richard B. Sellars James E. Burke Ralph S. Larsen

Selected subsidiaries

ALZA
ALZA
Corporation Cilag Crucell DePuy, Inc. Ethicon Endo-Surgery, Inc. Ethicon, Inc. Independence Technology, LLC J&J PRD Janssen Biotech Janssen Pharmaceutica LifeScan McNeil Consumer & Specialty Pharmaceuticals McNeil Nutritionals Ortho-McNeil Pharmaceutical Ortho-Neutrogena Penaten Tibotec

Major brands

Acuvue Aveeno Bactidol Band-Aid Benadryl Benecol
Benecol
(US license) Bengay Caladryl Clean & Clear Combantrin Desitin Imodium Johnson's Baby Lactaid Listerine Lomotil Motrin Mylanta Mylicon Neosporin Neutrogena Nicorette OneTouch Pepcid Plax Rembrandt Sinutab Splenda Sudafed Trosyd Tylenol Visine

Annual revenue: US$74.3 billion (FY 2014) Annual net income: US$16.3 billion (FY 2014) Employees: 118,700

v t e

Pharmaceutical companies of the United States

Current

Abbott Laboratories Acorda Therapeutics Aderis Pharmaceuticals Advaxis Alcon Alexion Pharmaceuticals Alkermes Allergan Alnylam Amgen Avax Technologies Baxter International BioCryst Pharmaceuticals Biogen Bioverativ Biovest Biovista Bristol-Myers Squibb Century Pharmaceuticals Ceragenix Pharmaceuticals Combe Incorporated CytoSport CytRx Danco Laboratories Eli Lilly and Company Endo Pharmaceuticals

Par Pharmaceutical

Galena Biopharma Genentech Gilead Sciences Ionis Pharmaceuticals Institute for OneWorld Health Intercept Pharmaceuticals Johnson & Johnson

Ethicon Janssen Biotech McNeil Consumer Healthcare Ortho-McNeil Pharmaceutical

Kinetic Concepts Mallinckrodt McKesson Corporation Melinta Therapeutics (formerly Rib-X Pharmaceuticals) Melior Discovery Mentholatum Merck & Co. Myriad Genetics Northwest Biotherapeutics Norwich Pharma Services NovaBay Pharmaceuticals Ovation Pharmaceuticals Perrigo Pfizer

Hospira Searle

Pharmaceutical Product Development Prasco Laboratories Procter & Gamble Proteon Therapeutics Purdue Pharma Quark Pharmaceuticals Regeneron Repros Therapeutics RespireRx Sarepta Therapeutics Savage Laboratories Sheffield Pharmaceuticals Spectrum Pharmaceuticals Tec Laboratories Titan Pharmaceuticals Trevena Inc Upsher-Smith Laboratories Ventria Bioscience Vertex Pharmaceuticals West Pharmaceutical Services

Former

Alza Amylin Pharmaceuticals ARIAD Pharmaceuticals Biolex Bradley Pharmaceuticals CancerVax Cephalon CoTherix Covance Covidien Cubist Pharmaceuticals Cutter Laboratories DNAPrint Genomics Epix Pharmaceuticals Forest Laboratories Genta ImClone Systems ISTA Pharmaceuticals King Pharmaceuticals KV Pharmaceutical Leiner Health Products Martek Biosciences Corporation S. E. Massengill Company Miles Laboratories Naurex Nereus Pharmaceuticals Nuvelo Organon International Ortho Pharmaceutical OSI Pharmaceuticals Parke-Davis Qualitest Schering-Plough Smith, Kline & French Sterling Drug Tanox TAP Pharmaceutical Products Trubion Upjohn Verus Pharmaceuticals Vion Pharmaceuticals, Inc. ViroPharma Wyeth Zonite Products Corporation

List of pharma

.