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Manuel Incra Mamani
Manuel Incra Mamani was a Bolivian Incan ''cascarillero'' (bark and seed hunter) who found a cinchona tree that had a higher proportion of quinine than most others. It went into commercial cultivation, providing most of the world's quinine. Life and work Mamani was an experienced bark and seed collector, and had worked for Charles Ledger since 1843. He was able to identify 29 different sorts of cinchona trees. Mamani waited through four years of unsuitable weather (frosts destroyed the seeds from the high-quinine plants), and gave offerings to mountain spirits, in order to obtain a sample of seed from the high-quinine cinchona in 1865. The seeds that Mamani provided were sent to Ledger's brother, George, who then sold them to the Dutch government, who then cultivated plants in Java Java (; id, Jawa, ; jv, ꦗꦮ; su, ) is one of the Greater Sunda Islands in Indonesia. It is bordered by the Indian Ocean to the south and the Java Sea to the north. With a population of 15 ...
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Manuel Incra Mamari
Manuel may refer to: People * Manuel (name) * Manuel (Fawlty Towers), a fictional character from the sitcom ''Fawlty Towers'' * Charlie Manuel, manager of the Philadelphia Phillies * Manuel I Komnenos, emperor of the Byzantine Empire * Manuel I of Portugal, king of Portugal Places *Manuel, Valencia, a municipality in the province of Valencia, Spain *Manuel Junction, railway station near Falkirk, Scotland Other * Manuel (American horse), a thoroughbred racehorse * Manuel (Australian horse), a thoroughbred racehorse *Manuel and The Music of The Mountains, a musical ensemble *Manuel (album), ''Manuel'' (album), music album by Dalida, 1974 See also

*Manny, a common nickname for those named Manuel {{disambiguation ...
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Cinchona
''Cinchona'' (pronounced or ) is a genus of flowering plants in the family Rubiaceae containing at least 23 species of trees and shrubs. All are native to the tropical Andean forests of western South America. A few species are reportedly naturalized in Central America, Jamaica, French Polynesia, Sulawesi, Saint Helena in the South Atlantic, and São Tomé and Príncipe off the coast of tropical Africa, and others have been cultivated in India and Java, where they have formed hybrids. ''Cinchona'' has been historically sought after for its medicinal value, as the bark of several species yields quinine and other alkaloids. These were the only effective treatments against malaria during the height of European colonialism, which made them of great economic and political importance. Trees in the genus are also known as fever trees because of their anti-malarial properties. The artificial synthesis of quinine in 1944, an increase in resistant forms of malaria, and the emergence of ...
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Quinine
Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to '' Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. It can be taken by mouth or intravenously. Malaria resistance to quinine occurs in certain areas of the world. Quinine is also used as an ingredient in tonic water to impart a bitter taste. Common side effects include headache, ringing in the ears, vision issues, and sweating. More severe side effects include deafness, low blood platelets, and an irregular heartbeat. Use can make one more prone to sunburn. While it is unclear if use during pregnancy causes harm to the baby, treating malaria during pregnancy with quinine when appropriate is still recommended. Quinine is an alkaloid, a naturally occurring chemical compound. How it works as ...
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Charles Ledger
Charles Ledger (4 March 1818 – 19 May 1905)B. G. Andrews,, ''Australian Dictionary of Biography'', Volume 5, Melbourne University Press, MUP, 1974, pp 73-74. Retrieved 9 Sep 2009 was an alpaca farmer noted for his work in connection with quinine, a treatment for History of malaria, malaria. Background Ledger belonged to a huguenot family that emigrated to England in the 18th century; he was born at 1 Bucklersbury, City of London, the son of George Ledger, a mercantile broker, and his wife Charlotte, ''née'' Warren. After leaving school he went to Peru and in 1836 was a clerk in a British merchant's office at Lima. It was at Lima that Charles rescued a drowning native Manuel Incra Mamani, who offered to become his servant. Alpaca career He became an expert in alpaca wool, and in 1842 began business as a dealer in South American products. In 1847 he was grazing sheep and cattle half-way between Tacna and La Paz, and in 1852 went to Sydney to inquire into the possibility of intr ...
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Java
Java (; id, Jawa, ; jv, ꦗꦮ; su, ) is one of the Greater Sunda Islands in Indonesia. It is bordered by the Indian Ocean to the south and the Java Sea to the north. With a population of 151.6 million people, Java is the world's most populous island, home to approximately 56% of the Indonesian population. Indonesia's capital city, Jakarta, is on Java's northwestern coast. Many of the best known events in Indonesian history took place on Java. It was the centre of powerful Hindu-Buddhist empires, the Islamic sultanates, and the core of the colonial Dutch East Indies. Java was also the center of the Indonesian struggle for independence during the 1930s and 1940s. Java dominates Indonesia politically, economically and culturally. Four of Indonesia's eight UNESCO world heritage sites are located in Java: Ujung Kulon National Park, Borobudur Temple, Prambanan Temple, and Sangiran Early Man Site. Formed by volcanic eruptions due to geologic subduction of the Austra ...
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Cinchona Calisaya
''Cinchona calisaya'' is a species of shrub or tree in the family Rubiaceae. It is native to the forests of the eastern slopes of the Andes, where they grow from in elevation in Peru , image_flag = Flag of Peru.svg , image_coat = Escudo nacional del Perú.svg , other_symbol = Great Seal of the State , other_symbol_type = National seal , national_motto = "Firm and Happy f ... and Bolivia. References Further reading * calisaya Flora of the Andes Flora of the Amazon Flora of Bolivia Flora of Colombia Trees of the Amazon Trees of Peru Medicinal plants of South America Quinine {{Cinchonoideae-stub ...
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19th-century Bolivian People
The 19th (nineteenth) century began on 1 January 1801 ( MDCCCI), and ended on 31 December 1900 ( MCM). The 19th century was the ninth century of the 2nd millennium. The 19th century was characterized by vast social upheaval. Slavery was abolished in much of Europe and the Americas. The First Industrial Revolution, though it began in the late 18th century, expanding beyond its British homeland for the first time during this century, particularly remaking the economies and societies of the Low Countries, the Rhineland, Northern Italy, and the Northeastern United States. A few decades later, the Second Industrial Revolution led to ever more massive urbanization and much higher levels of productivity, profit, and prosperity, a pattern that continued into the 20th century. The Islamic gunpowder empires fell into decline and European imperialism brought much of South Asia, Southeast Asia, and almost all of Africa under colonial rule. It was also marked by the collapse of the la ...
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1871 Deaths
Events January–March * January 3 – Franco-Prussian War – Battle of Bapaume: Prussians win a strategic victory. * January 18 – Proclamation of the German Empire: The member states of the North German Confederation and the south German states, aside from Austria, unite into a single nation state, known as the German Empire. The King of Prussia is declared the first German Emperor as Wilhelm I of Germany, in the Hall of Mirrors at the Palace of Versailles. Constitution of the German Confederation comes into effect. It abolishes all restrictions on Jewish marriage, choice of occupation, place of residence, and property ownership, but exclusion from government employment and discrimination in social relations remain in effect. * January 21 – Giuseppe Garibaldi's group of French and Italian volunteer troops, in support of the French Third Republic, win a battle against the Prussians in the Battle of Dijon. * February 8 – 1871 French legislative election el ...
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