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Magainin
The magainins are a class of antimicrobial peptides found in the African clawed frog (''Xenopus laevis''). The peptides are cationic, generally lack a stable conformation in water but form amphipathic α-helix in membranes; their mechanism against micro-organisms is unclear but they disrupt the cell membranes of a broad spectrum of bacteria, protozoa, and fungi. They were independently discovered at around the same time by the labs of Michael Zasloff at the NIH and Dudley H. Williams at the University of Cambridge. They were named by Zasloff, after the Hebrew word for "shield," מגן māgēn (Ashkenazi pronunciation: magain). Zasloff helped found a company, Magainin Pharmaceuticals (subsequently called Genaera) to develop magainins into drugs. One candidate was an analog of magainin called pexiganan (MSI-78) that the company developed as a topical agent for infected diabetic foot ulcer Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Zasloff
Michael A. Zasloff (born July 2, 1946) is an American physician, medical researcher, and entrepreneur. Zasloff is primarily known for his work on antimicrobial peptides. Early life Michael Alan Zasloff was born to a Jewish family, the son a dentist and an artist. Growing up on Manhattan's West Side, he studied at the Bronx High School of Science. Education Zasloff did his undergraduate work at Columbia University and earned his M.D. and Ph.D. from the New York University School of Medicine. He did his residency training in pediatrics at the Boston Children's Hospital and a research fellowship at Johns Hopkins University. In 1975 he joined the National Institutes of Health (NIH) as a postdoc. Professional career Zasloff stayed at the NIH after he finished his postdoc, and in 1981 he was made the Chief of the Human Genetics Branch of the National Institutes of Child Health and Human Development. In 1986 he discovered magainins, a family of antimicrobial peptides in the skin of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antimicrobial Peptides
Antimicrobial peptides (AMPs), also called host defence peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between prokaryotic and eukaryotic cells that may represent targets for antimicrobial peptides. These peptides are potent, broad spectrum antibiotics which demonstrate potential as novel therapeutic agents. Antimicrobial peptides have been demonstrated to kill Gram negative and Gram positive bacteria, enveloped viruses, fungi and even transformed or cancerous cells. Unlike the majority of conventional antibiotics it appears that antimicrobial peptides frequently destabilize biological membranes, can form transmembrane channels, and may also have the ability to enhance immunity by functioning as immunomodulators. Structure Antimicrobial peptides are a unique and diverse group of molecules, which are divided into subgroups on the basis of their amino acid composition and structure. Antimicrobial peptides are g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Clawed Frog
The African clawed frog (''Xenopus laevis'', also known as the xenopus, African clawed toad, African claw-toed frog or the ''platanna'') is a species of African aquatic frog of the family Pipidae. Its name is derived from the three short claws on each hind foot, which it uses to tear apart its food. The word ''Xenopus'' means 'strange foot' and ''laevis'' means 'smooth'. The species is found throughout much of Sub-Saharan Africa (Nigeria and Sudan to South Africa),Weldon; du Preez; Hyatt; Muller; and Speare (2004). Origin of the Amphibian Chytrid Fungus.' Emerging Infectious Diseases 10(12). and in isolated, introduced populations in North America, South America, Europe, and Asia. All species of the family Pipidae are tongueless, toothless and completely aquatic. They use their hands to shove food in their mouths and down their throats and a hyobranchial pump to draw or suck things in their mouth. Pipidae have powerful legs for swimming and lunging after food. They also use the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dudley H
Dudley is a large market town and administrative centre in the county of West Midlands, England, southeast of Wolverhampton and northwest of Birmingham. Historically an exclave of Worcestershire, the town is the administrative centre of the Metropolitan Borough of Dudley; in 2011 it had a population of 79,379. The Metropolitan Borough, which includes the towns of Stourbridge and Halesowen, had a population of 312,900. In 2014 the borough council named Dudley as the capital of the Black Country. Originally a market town, Dudley was one of the birthplaces of the Industrial Revolution and grew into an industrial centre in the 19th century with its iron, coal, and limestone industries before their decline and the relocation of its commercial centre to the nearby Merry Hill Shopping Centre in the 1980s. Tourist attractions include Dudley Zoo and Castle, the 12th century priory ruins, and the Black Country Living Museum. History Early history Dudley has a history dating back ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hebrew
Hebrew (; ; ) is a Northwest Semitic language of the Afroasiatic language family. Historically, it is one of the spoken languages of the Israelites and their longest-surviving descendants, the Jews and Samaritans. It was largely preserved throughout history as the main liturgical language of Judaism (since the Second Temple period) and Samaritanism. Hebrew is the only Canaanite language still spoken today, and serves as the only truly successful example of a dead language that has been revived. It is also one of only two Northwest Semitic languages still in use, with the other being Aramaic. The earliest examples of written Paleo-Hebrew date back to the 10th century BCE. Nearly all of the Hebrew Bible is written in Biblical Hebrew, with much of its present form in the dialect that scholars believe flourished around the 6th century BCE, during the time of the Babylonian captivity. For this reason, Hebrew has been referred to by Jews as '' Lashon Hakodesh'' (, ) since an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ashkenazi Hebrew
Ashkenazi Hebrew ( he, הגייה אשכנזית, Hagiyya Ashkenazit, yi, אַשכּנזישע הבֿרה, Ashkenazishe Havara) is the pronunciation system for Biblical and Mishnaic Hebrew favored for Jewish liturgical use and Torah study by Ashkenazi Jewish practice. Features As it is used parallel with modern Hebrew, its phonological differences are clearly recognized: * '' '' and '' '' are completely silent at all times in most forms of Ashkenazi Hebrew, where they are frequently both pronounced as a glottal stop in modern Hebrew. (Compare ''Yisroeil'' (Lithuanian) or ''Yisruayl'' (Polish-Galician) vs. ''Yisra'el'' (Israeli).) An earlier pronunciation of ''‘ayin'' as a velar nasal () is attested most prominently in Dutch Hebrew (and historically also the Hebrew of Frankfurt am Main). Vestiges of this earlier pronunciation are still found throughout the Yiddish-speaking world in names like ''Yankev'' (יעקבֿ) and words like ''manse'' (מעשׂה, more commonly pronounce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetic Foot Ulcer
Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process. Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength. Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques such as total contact casting. Surgery in some cases may improve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
