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MB-3 Tamoyo
MB-3 may refer to: * MB-3 (drug), an enzyme inhibitor * Thomas-Morse MB-3, a biplane from the 1920s * Martin-Baker MB 3 The Martin-Baker MB 3 was a British prototype fighter aircraft, developed from Martin-Baker’s earlier private ventures, the MB 1 and the MB 2. The design was notable for its heavy armament of six 20 mm Hispano cannons. The fatal cra ...
, an experimental WWII aircraft {{disambig ...
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MB-3 (drug)
MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5, which usually functions as a negative modulator of PGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the ''PPARGC1A'' gene. PPARGC1A is also known as human accelerated region 20 ( HAR20). It may, therefore, have played a key ro ..., and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation. See also * HY-124798 References {{pharm-stub Enzyme inhibitors Vinylidene compounds ...
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Thomas-Morse MB-3
The Thomas-Morse MB-3 was an open-cockpit biplane fighter primarily manufactured by the Boeing Company for the U.S. Army Air Service in 1922. The MB-3A was the mainstay fighter for the Air Service between 1922 and 1925. Development In March 1918, the United States Army Air Service requested several American aircraft manufacturers to design a new fighter, to be powered by a water-cooled Wright-Hispano H, a license-built Hispano-Suiza 8, to replace the French-built SPAD XIII.Pelletier ''Air Enthusiast'' September–October 2007, p. 46.Angelucci and Bowers 1987, pp. 420–421.Dorr and Donald, 1990, p. 20. The Thomas-Morse Aircraft Corporation of Ithaca, New York proposed the MB-3, designed by its British-born chief designer B. Douglas Thomas, to meet this requirement, with an order for four prototypes being placed in September 1918.Wegg 1990, p. 24. The MB-3 was a single seat two- bay biplane of similar layout to the SPAD XIII that it was intended to replace. It was of wood and f ...
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