MB-3 is a drug which acts as a potent and selective inhibitor of the

histone acetyltransferase Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-''N''-acetyllysine. DNA is wrapped around histones, and, by transferring an ...

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

GCN5 __NOTOC__ Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the ''KAT2A'' gene. Interactions GCN5L2 has been shown to interact with: * DDB1, * Ku70, * Ku80, * TADA2L, * TAF9, and * Transcription initiation protein S ...

, which usually functions as a negative modulator of

PGC-1α Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the ''PPARGC1A'' gene. PPARGC1A is also known as human accelerated region 20 ( HAR20). It may, therefore, have played a key ro ...

, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.

References

{{pharm-stub Enzyme inhibitors Vinylidene compounds

See also

References