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Luis Moroder
Luis Moroder (born 6 December 1940) is an Italian peptide chemist, who pioneered research on the interactions between peptide hormones and cell membrane-bound hormone receptors. He later expanded this research to other biological systems of medical relevance such as protein inhibitors, collagens, and synthetic proteins. A hallmark of his research is interdisciplinarity as reflected in his use and development of methods in organic chemistry, biophysics and molecular biology. He is a co-editor of the five-volume Houben-Weyl, Methods of Organic Chemistry, Synthesis of Peptides and Peptidomimetics. Since 2008 he is the editor-in-chief of the ''Journal of Peptide Science'', the official journal of the European Peptide Society. Early life, education and career Moroder studied chemistry at the University of Padova, where he graduated 1965 in chemistry with the doctoral thesis on synthesis of S-peptide of ribonuclease A in the laboratory of Ernesto Scoffone at the Institute of Organic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urtijëi
Urtijëi (; german: St. Ulrich in Gröden ; it, Ortisei ) is a town of 4,637 inhabitants in South Tyrol in northern Italy. It occupies the Val Gardena within the Dolomites, a mountain chain that is part of the Alps. Geography Urtijëi borders the following municipalities: Kastelruth, Villnöß, Lajen and Santa Cristina Gherdëina. History The Ladin-language name Urtijëi derives from the Latin word and the suffix '','' with the meaning "place of nettles". From 1860 to 1914 Urtijëi experienced a relevant economic growth due to the opening of a major road connecting Val Gardena to the main railroad; as a result the local woodcarving industry flourished. International tourism developed through the discovery of the Dolomites first by English tourists, and subsequently visitors from other parts of Austria-Hungary as well as the German Empire. Currently, the town's economy is mostly based on winter skiing tourism, summer hiking tourism, and woodcarving. Coat of arms The emblem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Fellow
A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a principal investigator. Although research fellow positions vary in different countries and academic institutions, it is in general that they are junior researchers who try to develop their research careers under the guidance of senior researchers. United Kingdom In many universities this position is a career grade of a ''Research Career Pathway'', following on from a postdoctoral position such as research associate, and may be open-ended, subject to normal probation regulations. Within such a path, the next two higher career grades are usually senior research fellow and professorial fellow. Although similar to the position of a research fellow, these two positions are research only posts, with the rise of the career grade there will normal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Products
A natural product is a natural Chemical compound, compound or chemical substance, substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary metabolite, primary or secondary metabolite, secondary metabolism. Within the field of medicinal chemistry, the definition is often further restric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Habilitation
Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a dissertation. The degree, abbreviated "Dr. habil." (Doctor habilitatus) or "PD" (for "Privatdozent"), is a qualification for professorship in those countries. The conferral is usually accompanied by a lecture to a colloquium as well as a public inaugural lecture. History and etymology The term ''habilitation'' is derived from the Medieval Latin , meaning "to make suitable, to fit", from Classical Latin "fit, proper, skillful". The degree developed in Germany in the seventeenth century (). Initially, habilitation was synonymous with "doctoral qualification". The term became synonymous with "post-doctoral qualification" in Germany in the 19th century "when holding a doctorate seemed no longer sufficient to guarantee a proficient transfer o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenocorticotropic Hormone
Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol by the cortex of the adrenal gland. ACTH is also related to the circadian rhythm in many organisms. Deficiency of ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary ad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Klaus H
Klaus is a German, Dutch and Scandinavian given name and surname. It originated as a short form of Nikolaus, a German form of the Greek given name Nicholas. Notable persons whose family name is Klaus * Billy Klaus (1928–2006), American baseball player * Chris Klaus (born 1973), American entrepreneur * Frank Klaus (1887–1948), German-American boxer, 1913 Middleweight Champion *Fred Klaus (born 1967), German footballer * Josef Klaus (1910–2001), Chancellor of Austria 1966–1970 *Karl Ernst Claus (1796–1864), Russian chemist *Václav Klaus (born 1941), Czech politician, former President of the Czech Republic * Walter K. Klaus (1912–2012), American politician and farmer Notable persons whose given name is Klaus *Brother Klaus, Swiss patron saint *Klaus Augenthaler (born 1957), German football player and manager *Klaus Badelt (born 1967), German composer *Klaus Barbie (1913–1991), German SS-Hauptsturmführer and Holocaust Perpetrator *Klaus Bargsten (1911–2000), G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribonuclease A
Pancreatic ribonuclease family (, ''RNase'', ''RNase I'', ''RNase A'', ''pancreatic RNase'', ''ribonuclease I'', ''endoribonuclease I'', ''ribonucleic phosphatase'', ''alkaline ribonuclease'', ''ribonuclease'', ''gene S glycoproteins'', ''Ceratitis capitata alkaline ribonuclease'', ''SLSG glycoproteins'', ''gene S locus-specific glycoproteins'', ''S-genotype-assocd. glycoproteins'', ''ribonucleate 3'-pyrimidino-oligonucleotidohydrolase'') is a superfamily of pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the RNA helix by complexing with single-stranded RNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Peptide Science
The ''Journal of Peptide Science'' is a monthly peer-reviewed scientific journal, published since 1995 by John Wiley & Sons on behalf of the European Peptide Society. The current editor-in-chief is Paolo Rovero ( Universita di Firenze). Abstracting and indexing The ''Journal of Peptide Science'' is abstracted and indexed by Chemical Abstracts Service, MEDLINE/PubMed, Scopus, and the Science Citation Index. According to the ''Journal Citation Reports'', the journal has a 2021impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 2.408, ranking it 66th out of 87 journals in the category "Chemistry Analytical" and 255th out of 297 journals in the category "Biochemistry & Molecular Biology". Most-cited papers The three most-cited papers published in this journal are: # ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Editor-in-chief
An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies. The highest-ranking editor of a publication may also be titled editor, managing editor, or executive editor, but where these titles are held while someone else is editor-in-chief, the editor-in-chief outranks the others. Description The editor-in-chief heads all departments of the organization and is held accountable for delegating tasks to staff members and managing them. The term is often used at newspapers, magazines, yearbooks, and television news programs. The editor-in-chief is commonly the link between the publisher or proprietor and the editorial staff. The term is also applied to academic journals, where the editor-in-chief gives the ultimate decision whether a submitted manuscript will be published. This decision is made by the editor-in-chief after seeking input from reviewers selected on the basis of re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptidomimetic
A peptidomimetic is a small protein-like chain designed to mimic a peptide. They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and Beta-peptide, β-peptides. Irrespective of the approach, the altered chemical structure is designed to advantageously adjust the molecular properties such as stability or biological activity. This can have a role in the development of drug-like compounds from existing peptides. Peptidomimetics can be prepared by cyclization of linear peptides or coupling of stable unnatural amino acids. These modifications involve changes to the peptide that will not occur naturally (such as altered backbones and the incorporation of nonnatural amino acids). Unnatural amino acids can be generated from their native analogs via modifications such as amine alkylation, side chain substitution, structural bond extension cyclization, and isosteric replacements within the amino acid backb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Houben-Weyl Methods Of Organic Chemistry
''Houben-Weyl Methods of Organic Chemistry'' (Ger. ''Methoden der Organischen Chemie'') established in 1909 by the German chemist Theodor Weyl, is a classic chemistry text. It consisted initially of two volumes and covered literature published as early as 1834. Heinrich J. Houben revised and reissued it in 1913. It is considered one of the most significant resources for chemists. Up to the 4th edition the work was published in German by Thieme from 1952 to 1987, with supplementary volumes published between 1982 and 1999, some of them (from 1990 on) in English. It consists of 16 volumes, some of which are further divided. Overall, the 4th edition consists of 90 individual books. A new English-language edition was published by Thieme from 2000 to 2010 as ''Science of Synthesis'' in 48 volumes. It is constantly updated. References Chemistry books {{chem-book-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
