|
Koichi Tanaka
is a Japanese electrical engineer who shared the Nobel Prize in Chemistry in 2002 for developing a novel method for mass spectrometric analyses of biological macromolecules with John Bennett Fenn and Kurt Wüthrich (the latter for work in NMR spectroscopy). Early life and education Tanaka was born and raised in Toyama, Japan, his biological mother died one month after he was born. Tanaka graduated from Tohoku University with a bachelor's degree in electrical engineering in 1983, afterward he joined Shimadzu Corporation, where he engaged in the development of mass spectrometers. Soft laser desorption For mass spectrometry analyses of a macromolecule, such as a protein, the analyte must be ionized and vaporized by laser irradiation. The problem is that the direct irradiation of an intense laser pulse on a macromolecule causes cleavage of the analyte into tiny fragments and the loss of its structure. In February 1985, Tanaka found that by using a mixture of ultra fine metal pow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Japanese Nobel Laureates
Since 1949, there have been 29 Japanese laureates of the Nobel Prize. The Nobel Prize is a Sweden-based international monetary prize. The award was established by the 1895 will and estate of Swedish chemist and inventor Alfred Nobel. It was first awarded in Physics, Chemistry, Physiology or Medicine, Literature, and Peace in 1901. An associated prize, thus far, the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel, also sometimes known as the Nobel Prize in Economics, has yet to be awarded to a Japanese national. The Nobel Prizes in the above specific sciences disciplines and the Prize in Economics, which is commonly identified with them, are widely regarded as the most prestigious award one can receive in those fields. Of Japanese winners, twelve have been physicists, eight chemists, three for literature, five for physiology or medicine, and one for efforts towards peace. In the 21st century, in the field of natural science, the number of Japanese winners ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tohoku University
, or is a Japanese national university located in Sendai, Miyagi in the Tōhoku Region, Japan. It is informally referred to as . Established in 1907, it was the third Imperial University in Japan and among the first three Designated National Universities, along with the University of Tokyo and Kyoto University. Tohoku University is a Top Type university of the Top Global University Project, and since 2020 has been ranked the best university in Japan by Times Higher Education. In 2016, Tohoku University had 10 faculties, 16 graduate schools and 6 research institutes, with a total enrollment of 17,885 students. The university's three core values are "Research First (研究第一主義)," "Open-Doors (門戸開放)," and "Practice-Oriented Research and Education (実学尊重)." History On June 22, 1907(明治40年,''Mēji yonjyunen''), the university was established under the name by the Meiji government as the third Imperial University of Japan, following the Tokyo Imperi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toyama, Toyama
is the capital city of Toyama Prefecture, Japan, located on the coast of the Sea of Japan in the Chūbu region on central Honshū, about north of the city of Nagoya and northwest of Tokyo. , the city had an estimated population of 415,844 in 176,643 households, and a population density of 335 persons per km2. Its total area was . Overview The city has been designated an environmental model city by the national government for its efforts to reduce the emission of greenhouse gases. Cityscapes File:Toyama Castle (4207284334).jpg, Toyama Castle（2009） File:Anyobo, Toyama, Toyama Prefecture 930-0881, Japan - panoramio (35).jpg, Skyline of Toyama City（2015） File:View from Toyama City Hall, north side.jpg, CBD of Toyama（2018） File:Sogawa st.jpeg, Downtown Sōgawa（2016） File:Fugan unga.JPG, Toyama Kansui park（2016） Geography Located in the middle of its prefecture, Toyama is a seaside city by the coast of the Sea of Japan. Its municipal territory borders with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
History Of Mass Spectrometry
The history of mass spectrometry has its roots in physical and chemical studies regarding the nature of matter. The study of gas discharges in the mid 19th century led to the discovery of anode and cathode rays, which turned out to be positive ions and electrons. Improved capabilities in the separation of these positive ions enabled the discovery of stable isotopes of the elements. The first such discovery was with the element neon, which was shown by mass spectrometry to have at least two stable isotopes: 20Ne (neon with 10 protons and 10 neutrons) and 22Ne (neon with 10 protons and 12 neutrons). Mass spectrometers were used in the Manhattan Project for the separation of isotopes of uranium necessary to create the atomic bomb. Prout's Hypothesis Prout's hypothesis was an early 19th-century attempt to explain the properties of the chemical elements using the internal structure of the atom. In 1815, the English chemist William Prout observed that the atomic weights that had been mea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japan Academy
The Japan Academy (Japanese: 日本学士院, ''Nihon Gakushiin'') is an honorary organisation and science academy founded in 1879 to bring together leading Japanese scholars with distinguished records of scientific achievements. The Academy is currently an extraordinary organ of the Ministry of Education, Culture, Sports, Science and Technology with its headquarters located in Taito, Tokyo, Japan. Election to the Academy is considered the highest distinction a scholar can achieve, and members enjoy life tenure and an annual monetary stipend. History In 1973, Meiroku-sha (Meairoku Society) was founded. The main people of Meiroku-sha involved in Meiroku-sha were from Kaiseijo (later transformed into University of Tokyo and so on) and Keio Gijuku (Keio University). In an effort to replicate the institutional landscape found in many Western nations, the leaders of the Meiji government sought to create a national academy of scholars and scientists modelled to the British Royal So ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toyama Prefecture
is a prefecture of Japan located in the Chūbu region of Honshu. Toyama Prefecture has a population of 1,044,588 (1 June 2019) and has a geographic area of 4,247.61 km2 (1,640.01 sq mi). Toyama Prefecture borders Ishikawa Prefecture to the west, Gifu Prefecture to the south, Nagano Prefecture to the east, and Niigata Prefecture to the northeast. Toyama is the capital and largest city of Toyama Prefecture, with other major cities including Takaoka, Imizu, and Nanto. Toyama Prefecture is part of the historic Hokuriku region, and the majority of prefecture's population lives on Toyama Bay, one of the largest bays in Japan. Toyama Prefecture is the leading industrial prefecture on the Japan Sea coast and has the advantage of cheap electricity from abundant hydroelectric resources. Toyama Prefecture contains the only known glaciers in East Asia outside of Russia, first recognized in 2012, and 30% of the prefecture's area is designated as national parks. History Hist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analytical Chemistry (journal)
''Analytical Chemistry'' is a biweekly peer-reviewed scientific journal published since 1929 by the American Chemical Society. Articles address general principles of chemical measurement science and novel analytical methodologies. Topics commonly include chemical reactions and selectivity, chemometrics and data processing, electrochemistry, elemental and molecular characterization, imaging, instrumentation, mass spectrometry, microscale and nanoscale systems, -omics, sensing, separations, spectroscopy, and surface analysis. It is abstracted and indexed in Chemical Abstracts Service, CAB International, EBSCOhost, ProQuest, PubMed, Scopus, and the Science Citation Index Expanded. According to the ''Journal Citation Reports'', it has a 2020 impact factor of 6.986 . The editor-in-chief is Jonathan V. Sweedler (University of Illinois). See also * List of chemistry journals References External links * {{DEFAULTSORT:Analytical Chemistry (Journal) Analytical Chemistry Analyti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matrix-assisted Laser Desorption/ionization
In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy absorbing matrix to create ions from large molecules with minimal fragmentation. It has been applied to the analysis of biomolecules ( biopolymers such as DNA, proteins, peptides and carbohydrates) and various organic molecules (such as polymers, dendrimers and other macromolecules), which tend to be fragile and fragment when ionized by more conventional ionization methods. It is similar in character to electrospray ionization (ESI) in that both techniques are relatively soft (low fragmentation) ways of obtaining ions of large molecules in the gas phase, though MALDI typically produces far fewer multi-charged ions. MALDI methodology is a three-step process. First, the sample is mixed with a suitable matrix material and applied to a metal plate. Second, a pulsed laser irradiates the sample, triggering ablation and desorption of the sample and matrix materi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, hydrogen cyanide), are not classified as organic compounds and are considered inorganic. Other than those just named, little consensus exists among chemists on precisely which carbon-containing compounds are excluded, making any rigorous definition of an organic compound elusive. Although organic compounds make up only a small percentage of Earth's crust, they are of central importance because all known life is based on organic compounds. Living t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Karas
Michael Karas (born 1952) is a German physical chemistry scientist and Professor, known for his researches on matrix-assisted laser desorption/ionization (MALDI), a technique in mass spectrometry. Michael Karas studied Chemistry at the University of Bonn, where he obtained a PhD in the field of physical chemistry in 1982. From 1983 to 1986, he was part of the Hillenkamp research group in the Institut für Biophysik at Johann Wolfgang Goethe University Frankfurt am Main. In 1987, he followed Hillenkamp at Münster and both formed a group in the Faculty of Medicine at University of Münster The University of Münster (german: Westfälische Wilhelms-Universität Münster, WWU) is a public research university located in the city of Münster, North Rhine-Westphalia in Germany. With more than 43,000 students and over 120 fields of stud .... He returned to Frankfurt in 1995 as a full professor for Instrumental Analytical Chemistry. Awards * 1997: Recipient of the John B. Fenn Aw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Hillenkamp
Franz Hillenkamp (March 18, 1936 – August 22, 2014) was a German scientist known for his development of the laser microprobe mass analyzer and, with Michael Karas, matrix-assisted laser desorption/ionization (MALDI). Early life and education Franz Hillenkamp was born in 1936 in Essen, Germany. He attended high school in Lünen, graduating in 1955. He received a M.S. degree in electrical engineering from Purdue University in 1961. He received a Ph.D. (Dr.-Ing.) from the Technische Universität München in 1966 with a thesis entitled “An Absolutely Calibrated Calorimeter for the Measurement of Pulsed Laser Radiation.” Academic career Hillenkamp was a professor at Goethe University Frankfurt in Frankfurt from 1982 to 1986. In 1986, he became a professor on the Medical Faculty of the University of Münster where he remained until his retirement in 2001. Laser microprobe In 1973, Hillenkamp developed a high performance laser microprobe mass spectrometer with a spatial resolution ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> History Of Mass Spectrometry")
