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Krishna Chatterjee
Vengalil Krishna Kumar Chatterjee is a Professor of Endocrinology in the Department of Medicine at the University of Cambridge and a Fellow of Churchill College, Cambridge. He is also the director of the Cambridge Clinical Research Centre which is part of the National Institute for Health Research (NIHR). Education Chatterjee was educated at Wolfson College, Oxford where he was awarded Bachelor of Arts and Bachelor of Medicine, Bachelor of Surgery degrees in 1982. Research and career Chatterjee is distinguished for his discoveries of genetic disorders of thyroid gland formation, regulation of hormone synthesis and hormone action, which have advanced fundamental knowledge of the hypothalamic–pituitary–thyroid axis. He has identified dominant negative inhibition by defective nuclear receptors as a common mechanism in thyroid hormone resistance and peroxisome proliferator-activated receptor gamma (PPARγ)-mediated insulin resistance. He has shown how deficiency of human sele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic development a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2023 New Year Honours
The 2023 New Year Honours are appointments by some of the 15 Commonwealth realms to various orders and honours to recognise and reward good works by citizens of those countries. The New Year Honours are awarded as part of the New Year celebrations at the start of January and those for 2023 were announced on 30 December 2022. The recipients of honours are displayed as they were styled before their new honour and arranged by the country whose ministers advised Charles III on the appointments, then by the honour and by the honour's grade (''i.e.'' Knight/Dame Grand Cross, Knight/Dame Commander ''etc.''), and then by divisions (''i.e.'' Civil, Diplomatic, and Military), as appropriate. The 2023 New Year Honours was the first honours list issued by King Charles III. United Kingdom Below are the individuals appointed by Charles III in his right as King of the United Kingdom with honours within his own gift and with the advice of the Government for other honours. The Order of the Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Commander Of The Order Of The British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established on 4 June 1917 by King George V and comprises five classes across both civil and military divisions, the most senior two of which make the recipient either a knight if male or dame if female. There is also the related British Empire Medal, whose recipients are affiliated with, but not members of, the order. Recommendations for appointments to the Order of the British Empire were originally made on the nomination of the United Kingdom, the self-governing Dominions of the Empire (later Commonwealth) and the Viceroy of India. Nominations continue today from Commonwealth countries that participate in recommending British honours. Most Commonwealth countries ceased recommendations for appointments to the Order of the British Empire when they cre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nick Wareham
Nicholas J. Wareham is a British epidemiologist who researches obesity, diabetes, and other metabolic disorders. He is director of the MRC Epidemiology Unit and co-director of the Institute of Metabolic Science at the University of Cambridge. He is also a Wellcome Trust Senior Fellow in Clinical Science at the University of Cambridge, the director of the University's Centre for Diet and Activity Research (CEDAR), and the co-leader of the University's Aetiology of Diabetes and Related Metabolic Disorders Programme. He was educated at St Thomas's Hospital Medical School and the London School of Hygiene and Tropical Medicine. Before joining the faculty at Cambridge, he worked at Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le .... References External links * Li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antonio Vidal-Puig
Antonio Vidal-Puig (born Valencia, Spain , image_flag = Bandera de España.svg , image_coat = Escudo de España (mazonado).svg , national_motto = ''Plus ultra'' (Latin)(English: "Further Beyond") , national_anthem = (English: "Royal March") , i ... June 12, 1962) is a Spanish medical doctor and scientist who works as a Professor of Nutrition, Molecular Nutrition and Metabolism at the University of Cambridge (UK), best known for advancing the concept that pharmacological targeting of brown fat may serve to treat overweight and obesity in affected individuals, as well as for introducing the concept of adipose tissue "expandability" as an important factor in the pathogenesis of insulin resistance in the context of Energy homeostasis, positive energy balance. His published work focuses on areas such as adipose tissue metabolism and lipotoxicity, regulation of insulin secretion, and the pathophysiology of metabolic syndrome, obesity, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stephen O'Rahilly
Sir Stephen Patrick O'Rahilly (born 1 April 1958) is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders. Education O'Rahilly was born in Dublin, IrelandEllen Ruppel ShellFat Genes Discover Magazine, 1 May 2000 and educated at Beneavin College. He attended University College Dublin to study medicine. Research O'Rahilly undertook research into Type 2 diabetes and insulin resistance at the University of Oxford and Harvard Medical School, before joining the University of Cambridge where he is a Professor of Clinical Biochemistry and Medicine, Director of the Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Director of the MRC Metabolic Diseases Unit and co-director of the Wellcome-MRC Institute of Metabolic Science. He is also the scientific Director of the National Institute for Health and Care Research (NIHR) Cambridge Biomed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sadaf Farooqi
Ismaa Sadaf Farooqi is a Wellcome Trust Senior Research fellow in Clinical Science, professor of Metabolism and Medicine at the University of Cambridge and a consultant physician at Addenbrooke's Hospital in Cambridge, UK. Education Farooqi was educated at the University of Birmingham where she studied medicine, and was awarded a Bachelor of Medicine, Bachelor of Surgery degree in 1993.Sadaf Farooqi's After working as a pre-registration house officer and senior house officer, she moved into research and was awarded a PhD in 2001 from the University of Cambridge for research on the genetics of severe childhood obesity. Research Farooqi's research investigates the genetics of obesity. Using candidate genes found in patients with severe obesity, her research group have identified patients with mutations in genes encoding leptin, the leptin receptor and biological targets of leptin action, such as the Melanocortin 4 receptor (MC4R). Her group have also demonstrated that the cent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Creative Commons License
A Creative Commons (CC) license is one of several public copyright licenses that enable the free distribution of an otherwise copyrighted "work".A "work" is any creative material made by a person. A painting, a graphic, a book, a song/lyrics to a song, or a photograph of almost anything are all examples of "works". A CC license is used when an author wants to give other people the right to share, use, and build upon a work that the author has created. CC provides an author flexibility (for example, they might choose to allow only non-commercial uses of a given work) and protects the people who use or redistribute an author's work from concerns of copyright infringement as long as they abide by the conditions that are specified in the license by which the author distributes the work. There are several types of Creative Commons licenses. Each license differs by several combinations that condition the terms of distribution. They were initially released on December 16, 2002, by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroid Disease
Thyroid disease is a medical condition that affects the function of the thyroid gland. The thyroid gland is located at the front of the neck and produces thyroid hormones that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ. These hormones normally act in the body to regulate energy use, infant development, and childhood development. There are five general types of thyroid disease, each with their own symptoms. A person may have one or several different types at the same time. The five groups are: # Hypothyroidism (low function) caused by not having enough free thyroid hormones # Hyperthyroidism (high function) caused by having too many free thyroid hormones # Structural abnormalities, most commonly a goiter (enlargement of the thyroid gland) # Tumors which can be benign (not cancerous) or cancerous # Abnormal thyroid function tests without any clinical symptoms (subclinical hypothyroidism or subclinical hyperthyroidism). In som ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Selenocysteine
Selenocysteine (symbol Sec or U, in older publications also as Se-Cys) is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur. Selenocysteine is present in several enzymes (for example glutathione peroxidases, tetraiodothyronine 5′ deiodinases, thioredoxin reductases, formate dehydrogenases, glycine reductases, selenophosphate synthetase 2, methionine-''R''-sulfoxide reductase B1 (SEPX1), and some hydrogenases). It occurs in all three domains of life, including important enzymes (listed above) present in humans. Selenocysteine was discovered by biochemist Thressa Stadtman at the National Institutes of Health. Chemistry Selenocysteine is the Se-analogue of cysteine. It is rarely encountered outside of living tissue (and is not available commercially) because it is very susceptible to air-oxidation. More common is the oxidized derivative selenocystine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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