Vengalil Krishna Kumar Chatterjee
[ ] [ is a ]Professor
Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who pr ...
of Endocrinology
Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...
in the Department of Medicine at the University of Cambridge
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
Fellow
A fellow is a concept whose exact meaning depends on context.
In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements.
Within the context of higher education ...
of Churchill College, Cambridge
Churchill College is a constituent college of the University of Cambridge, England. It has a primary focus on science, engineering and technology, but still retains a strong interest in the arts and humanities.
In 1958, a trust was establish ...
.National Institute for Health Research
The National Institute for Health and Care Research (NIHR) is the British government’s major funder of clinical, public health, social care and translational research. With a budget of over £1.2 billion in 2020–21, its mission is to "impr ...
(NIHR).
Education
Chatterjee was educated at Wolfson College, Oxford
Wolfson College () is a constituent college of the University of Oxford in England. Located in north Oxford along the River Cherwell, Wolfson is an all-graduate college with around sixty governing body fellows, in addition to both research and ...
where he was awarded Bachelor of Arts
Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four years ...
and Bachelor of Medicine, Bachelor of Surgery
Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United King ...
degrees in 1982.[
]
Research and career
Chatterjee is distinguished for his discoveries of genetic disorder
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders ...
s of thyroid
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thy ...
gland formation, regulation of hormone
A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...
synthesis and hormone action, which have advanced fundamental knowledge of the hypothalamic–pituitary–thyroid axis
The hypothalamic–pituitary–thyroid axis (HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress.
As its na ...
.[ He has identified dominant negative inhibition by defective ]nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of speci ...
s as a common mechanism in thyroid hormone resistance
Thyroid hormone resistance (also resistance to thyroid hormone (RTH), and sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or ...
and peroxisome proliferator-activated receptor gamma (PPARγ)-mediated insulin resistance
Insulin resistance (IR) is a pathological condition in which cell (biology), cells fail to respond normally to the hormone insulin.
Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood gluco ...
.[ ] He has shown how deficiency of human selenocysteine
Selenocysteine (symbol Sec or U, in older publications also as Se-Cys) is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the s ...
-containing proteins causes a multisystem disease, including disordered thyroid hormone metabolism. He seeks to translate such understanding into better diagnosis and therapy of both rare and common thyroid conditions.[ One or more of the preceding sentences incorporates text from the royalsociety.org website where: ]
Notable Cambridge scientists with whom Chatterjee has shared paper authorship include Sadaf Farooqi
Ismaa Sadaf Farooqi is a Wellcome Trust Senior Research fellow in Clinical Science, professor of Metabolism and Medicine at the University of Cambridge and a consultant physician at Addenbrooke's Hospital in Cambridge, UK.
Education
Farooqi w ...
, Stephen O'Rahilly
Sir Stephen Patrick O'Rahilly (born 1 April 1958) is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders.
Education
...
, Antonio Vidal-Puig
Antonio Vidal-Puig (born Valencia, Spain
, image_flag = Bandera de España.svg
, image_coat = Escudo de España (mazonado).svg
, national_motto = ''Plus ultra'' (Latin)(English: "Further Beyond")
, national_ant ...
, and Nick Wareham
Nicholas J. Wareham is a British epidemiologist who researches obesity, diabetes, and other metabolic disorders. He is director of the MRC Epidemiology Unit and co-director of the Institute of Metabolic Science at the University of Cambridge. He i ...
.
Chatterjee was appointed Commander of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established o ...
(CBE) in the 2023 New Year Honours
The 2023 New Year Honours are appointments by some of the 15 Commonwealth realms to various orders and honours to recognise and reward good works by citizens of those countries. The New Year Honours are awarded as part of the New Year celebration ...
for services to people with endocrine disorders.
References
Fellows of the Royal Society
Fellows of the Academy of Medical Sciences (United Kingdom)
Fellows of Churchill College, Cambridge
NIHR Senior Investigators
Alumni of the University of Oxford
Living people
1958 births
British endocrinologists
Commanders of the Order of the British Empire
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