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Kishi, Y
is a Japanese chemist who is the Morris Loeb Professor of Chemistry at Harvard University. He is known for his contributions to the sciences of organic synthesis and total synthesis. Kishi was born in Nagoya, Japan and attended Nagoya University, where he obtained both his BS and PhD degrees. He was a postdoctoral research fellow at Harvard University where he worked with Robert Burns Woodward. From 1966 through 1974, he was a professor of chemistry at Nagoya University. Since 1974, Kishi has been a professor of chemistry at Harvard University. Kishi's research has focused on the total synthesis of complex natural products. The accomplishments of his research group include the total syntheses of palytoxin, mycolactones, halichondrins, saxitoxin, tetrodotoxin, geldanamycin, batrachotoxin and many others. Kishi has also contributed to the development of new chemical reactions including the Nozaki–Hiyama–Kishi reaction. Recognition *1999 Imperial Prize of the Japan A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nagoya
is the largest city in the Chūbu region, the fourth-most populous city and third most populous urban area in Japan, with a population of 2.3million in 2020. Located on the Pacific coast in central Honshu, it is the capital and the most populous city of Aichi Prefecture, and is one of Japan's major ports along with those of Tokyo, Osaka, Kobe, Yokohama, and Chiba. It is the principal city of the Chūkyō metropolitan area, which is the third-most populous metropolitan area in Japan with a population of 10.11million in 2020. In 1610, the warlord Tokugawa Ieyasu, a retainer of Oda Nobunaga, moved the capital of Owari Province from Kiyosu to Nagoya. This period saw the renovation of Nagoya Castle. The arrival of the 20th century brought a convergence of economic factors that fueled rapid growth in Nagoya, during the Meiji Restoration, and became a major industrial hub for Japan. The traditional manufactures of timepieces, bicycles, and sewing machines were followed by th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Halichondrin
Halichondrin B is a polyether macrolide originally isolated from the marine sponge ''Halichondria okadai'' by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in ''in vivo'' studies. Halichondrin B was highly prioritized for development as a novel anticancer therapeutic by the United States National Cancer Institute and, in 1991, was the original test case for identification of mechanism of action (in this case, tubulin-targeted mitotic inhibitor) by NCI's then-brand-new " 60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard University in 1992, an achievement that ultimately enabled the discovery and development of the structurally simplified and pharmaceutically optimized analog eribulin (E7389, ER-086526, NSC-707389). Eribulin was approved by the U.S. Food and Drug Administration o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University Faculty
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hitoshi Nozaki
, sometimes spelled Hitosi, was a Japanese chemist specializing in the field of organic chemistry, known as the head of Japanese organic chemistry research, and one of the discoverers of Nozaki–Hiyama–Kishi reaction. He was Emeritus Professor of Kyoto University. Life Nozaki was born in Okayama, Japan, in 1922. He received his BS and PhD degree, respectively, from the Kyoto Imperial University. Contributions In Japan, Hitoshi Nozaki was one of the leaders of the organic chemistry academic circles during the period of Japanese post-war economic miracle. *Terpene-based synthetic of carboxylic cation *Nozaki–Hiyama–Kishi reaction Notable students * Ryoji Noyori: 2001 Nobel Prize in Chemistry winner. *Yoshito Kishi: Professor at Harvard University. Recognition *1979 Chemistry Society of Japan(CSJ) Award *1986 Japan Academy Prize *1986 Medal with Purple Ribbon *1992 Order of the Sacred Treasure *1993 Special Award in Synthetic Organic Chemistry, Japan *1999 Member of Jap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ryoji Noyori Prize
The Ryoji Noyori Prize was established by the Society of Synthetic Organic Chemistry, Japan in 2002 to commemorate Ryōji Noyori winning the 101st Nobel Prize in Chemistry as well as the 60th anniversary of the Society of Synthetic Organic Chemistry. The prize is given "to recognize and encourage outstanding contributions to research in asymmetric synthetic chemistry defined in its broadest sense." The prize is sponsored by Takasago International Corporation. Prizewinners SourceNoyori Prize winners *2002 – Henri B. Kagan *2003 – Gilbert Stork *2004 – Dieter Seebach *2005 – Tsutomu Katsuki *2006 – David A. Evans *2007 – *2008 – Andreas Pfaltz *2009 – Yoshio Okamoto *2010 – Eric Jacobsen (chemist), Eric N. Jacobsen *2011 – Hisashi Yamamoto *2012 – Masakatsu Shibasaki *2013 – Barry Trost *2014 – Dieter Enders *2015 – Larry E. Overman *2016 – *2017 – David MacMillan *2018 – Yoshito Kishi *2019 – Scott E. Denmark *2020 – Tsuneo Imamoto *2021 – E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of The Sacred Treasure
The is a Japanese order, established on 4 January 1888 by Emperor Meiji as the Order of Meiji. Originally awarded in eight classes (from 8th to 1st, in ascending order of importance), since 2003 it has been awarded in six classes, the lowest two medals being abolished that year. Originally a male-only decoration, the order has been made available to women since 1919. The Order of the Sacred Treasure, which had 8 ranks until 2003, was awarded as a slightly lower rank than the Order of the Rising Sun for men and the Order of the Precious Crown for women. For example, the 1st class of the Order of the Sacred Treasure has been treated as between the 1st class and the 2nd class of the Order of the Rising Sun and the Order of the Precious Crown, and the 2nd class of the Order of the Sacred Treasure has been treated as between the 2nd class and the 3rd class of the Order of the Rising Sun and the Order of the Precious Crown. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Person Of Cultural Merit
is an official Japanese recognition and honor which is awarded annually to select people who have made outstanding cultural contributions. This distinction is intended to play a role as a part of a system of support measures for the promotion of creative activities in Japan. By 1999, 576 people had been selected as Persons of Cultural Merit. Ministry of Education, Culture, Sports, Science and Technology (Japan) ''Culture 2000''./ref> System of recognition The Order of Culture and Persons of Cultural Merit function in tandem to honor those who have contributed to the advancement and development of Japanese culture in a variety of fields, including academia, arts, science and sports. ''Yomiuri Shimbun.'' October 29, 2008. Persons of Cultural Merit [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Guenther Award
The Ernest Guenther Award in the Chemistry of Natural Products is an American Chemical Society (ACS) award in the field of the chemistry of natural products. The purpose of the award is to recognize and encourage outstanding achievements in the analysis, structure elucidation, and chemical synthesis of natural products, with special consideration given to the independence of thought and originality. The award is granted regardless of race, gender, age, religion, ethnicity, nationality, sexual orientation, gender expression, gender identity, presence of disabilities, and educational background. The award consists of $6,000, a medallion, and a certificate. The medallion is presented during an award address. The award was established in 1948 by Fritzsche Dodge and Olcott Inc. to mark the 75th anniversary of the founding of the company. Since 1969,''Fritsche Award in Essential Oils Named for Dr. Guenther.'' In: ''Journal of the American Oil Chemists' Society.'' 44, 1967, S. A626– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahedron Prize
The Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry is awarded annually by Elsevier, the publisher of Tetrahedron Publications. It was established in 1980 and named in honour of the founding co-chairmen of these publications, Professor Sir Robert Robinson and Professor Robert Burns Woodward. The prize consists of a gold medal, a certificate, and a monetary award of US $15,000. Prizewinners Winners of the prize are: See also * List of chemistry awards This list of chemistry awards is an index to articles about notable awards for chemistry. It includes awards by the Royal Society of Chemistry, the American Chemical Society, the Society of Chemical Industry and awards by other organizations. ... References {{reflist Awards established in 1981 British science and technology awards Chemistry awards ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial Prize Of The Japan Academy
The is a prestigious honor conferred to two of the recipients of the Japan Academy Prize. Overviews It is awarded in two categories: humanities and natural sciences. The Emperor and Empress visit the awarding ceremony and present a vase to the awardees. Laureates * 2019 — Makoto Fujita (109th) * 2018 — , Chikashi Toyoshima (108th) * 2017 — (107th) * 2016 — Kazutoshi Mori (106th) * 2015 — Hideo Hosono * 2014 — Isamu Akasaki * 2013 — , Yoshinori Tokura * 2012 — , Keiichi Namba * 2011 — , (101st)Japan Academy 101st 20 June 2011 retrieved 2011-08-15 * 2010 — , Shinya Yamanaka (100th)Japan Academy 91st-100th retrieved 2011-08-15 * 2009 — , (99th) * 2008 — (98th) * 2007 — , Shizuo Akira (97th) * 2006 — Shuh Narumiya (96th) * 2005 — Kazuya Kato (95th) * 2004 — , Takeshi Yasumoto (94th) * 2003 — Mitsuhiro Yanagida (93rd) * 2002 — , Sumio Iijima (92nd) * 2001 — Fumio Hayashi, Makoto Asashima (91st) * 2000 — , Shigekazu Nagata (90th)Ja ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nozaki–Hiyama–Kishi Reaction
The Nozaki–Hiyama–Kishi reaction is a nickel/ chromium coupling reaction forming an alcohol from the reaction of an aldehyde with an allyl or vinyl halide. In their original 1977 publication, Tamejiro Hiyama and Hitoshi Nozaki reported on a chromium(II) salt solution prepared by reduction of chromic chloride by lithium aluminium hydride to which was added benzaldehyde and allyl chloride: : Compared to Grignard reactions, this reaction is very selective towards aldehydes with large tolerance towards a range of functional groups such as ketones, esters, amides and nitriles. Enals give exclusively 1,2-addition. Solvents of choice are DMF and DMSO, one solvent requirement is solubility of the chromium salts. Nozaki–Hiyama–Kishi reaction is a useful method for preparing medium-size rings. In 1983 the scope was extended by the same authors to include vinyl halides or triflates and aryl halides. It was observed that the success of the reaction depended on the source o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Batrachotoxin
Batrachotoxin (BTX) is an extremely potent cardio- and neurotoxic steroidal alkaloid found in certain species of beetles, birds, and frogs. The name is from the Greek word grc, βάτραχος, bátrachos, frog, label=none. Structurally-related chemical compounds are often referred to collectively as batrachotoxins. It is an extremely poisonous alkaloid. In certain frogs, this alkaloid is present mostly on the skin. Such frogs are among those used for poisoning darts. Batrachotoxin binds to and irreversibly opens the sodium channels of nerve cells and prevents them from closing, resulting in paralysis and death. No antidote is known. History Batrachotoxin was discovered by Fritz Märki and Bernhard Witkop, at the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. Märki and Witkop separated the potent toxic alkaloids fraction from ''Phyllobates bicolor'' and determined its chemical properties in 1963. They isolat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
