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Kazutoshi Mori
is a Japanese molecular biologist known for research on unfolded protein response. He is a professor of Biophysics at the Graduate School of Science, Kyoto University, and shared the 2014 Albert Lasker Basic Medical Research Award with Peter Walter for discoveries concerning the unfolded protein response — an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and signals the nucleus to carry out corrective measures. Early life and education Mori was born in 1958 in Kurashiki, Okayama. In the elementary school era, he was good at mathematics and arithmetic, and learned from the newspaper about the existence of quarks. In the middle school era, he was influenced by the Nobel Prize in Physics of Hideki Yukawa, and he decided to study physics at the Faculty of Science at Kyoto University (at the time, the golden age of elementary particle physics). However, he was finally admitted to the Department of Synthetic Chemistry of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kurashiki, Okayama
is a historic city located in western Okayama Prefecture, Japan, sitting on the Takahashi River, on the coast of the Inland Sea. As of March 31, 2017, the city has an estimated population of 483,576 and a population density of 1,400 persons per km². The total area is 355.63 km². History The modern city of Kurashiki was founded on April 1, 1928. Previously, it was the site of clashes between the Taira and Minamoto clans during the Heian period. It gradually developed as a river port. During the Edo period, it became an area directly controlled by the shogunate. Distinctive white-walled, black-tiled warehouses were built to store goods. During the Meiji Restoration (Japan's Industrial Revolution period), factories were built, including the Ohara Spinning Mill, which still stands as the nostalgic tourist attraction Ivy Square. On August 1, 2005, the town of Mabi (from Kibi District), and the town of Funao (from Asakuchi District) were merged with Kurashiki. Geography C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physics
) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "MDCCCXXXIII" above, followed by (smaller) "OB•" then "MDCCCXCVI" below. , awarded_for = Outstanding contributions for humankind in the field of Physics , presenter = Royal Swedish Academy of Sciences , location = Stockholm, Sweden , date = , reward = 9 million Swedish kronor (2017) , year = 1901 , holder_label = Most recently awarded to , holder = Alain Aspect, John Clauser, and Anton Zeilinger , most_awards = John Bardeen (2) , website nobelprize.org, previous = 2021 , year2=2022, main=2022, next=2023 The Nobel Prize in Physics is a yearly award given by the Royal Swedish Academy of Sciences for those who have made the most outstanding contributions for humankind in the field of physics. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ire1
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ''ERN1'' gene. Function The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals (mainly the unfolded protein response). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. Signaling IRE1α possesses two functional enzymatic domains, an endonuclease and a trans-autophosphorylation kinase domain. Upon activation, IRE1α oligomerizes and carries out an unconventional RNA splicing activity, removing an intron from the X-box binding protein 1 ( XBP1) mRNA, and allowing it to become translated into a functional transcription factor, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATF6
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ''ATF6'' gene and is involved in the unfolded protein response. Function ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones. See also * Activating transcription factor Interactions ATF6 has been shown to interact with YY1 and Serum response factor Serum response factor, also known as SRF, is a transcription factor protein. Function Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum .... References Further reading * * * * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hac1 Xbp1 Intron
The bZIP intron RNA motif is an RNA structure guiding splicing of a non-canonical intron from bZIP-containing genes called HAC1 in yeast, XBP1 in Metazoa, Hxl1 or Cib1 in Basidiomycota and bZIP60 in plants. Splicing is performed independently of the spliceosome by Ire1, a kinase with endoribonuclease activity. Exons are joined by a tRNA ligase. Recognition of the intron splice sites is mediated by a base-paired secondary structure of the mRNA that forms at the exon/intron boundaries. Splicing of the bZIP intron is a key regulatory step in the unfolded protein response (UPR). The Ire-mediated unconventional splicing was first described for HAC1 in ''S. cerevisiae''. Consensus structure The secondary structure of the bZIP intron is very well conserved, and consists of two hairpins (H2 and H3) around the splice sites, and an extended hairpin (H1) that brings the splice sites together (see figure). The sequence of the intron is well conserved only around the splice sites. Non-can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Texas Southwestern Medical Center
The University of Texas Southwestern Medical Center (UT Southwestern or UTSW) is a public academic health science center in Dallas, Texas. With approximately 18,800 employees, more than 2,900 full-time faculty, and nearly 4 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and state of Texas.https://utsystem.edu/sites/default/files/documents/publication/2018/fast-facts/fast-facts-09-2018.pdf UT Southwestern's William P. Clements Jr University Hospital is nationally ranked in nine specialties by '' U.S. News & World Report'' and ranked the best hospital in the Dallas-Fort Worth/North Texas region. Forbes ranked UT Southwestern Medical Center as the top health care employer in the state of Texas and the top health care employer to new graduates in the United States. UT Southwestern's operating budget in 2021 was more than $4.1 billion, and is the largest medical institution in the Dallas–Fort Worth Metroplex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gifu Pharmaceutical University
is a municipal university located in the city of Gifu, Gifu, Gifu, Gifu Prefecture, Japan. The predecessor of the school was founded in 1932, and it was chartered as a university in 1949.''Gifu-shi no Ayumi (Outline of Gifu City 2005)''. Gifu City Hall, April 2005. International exchanges The university has added to Gifu's sister city exchanges by becoming a sister university or setting up an academic exchange program with three of Gifu's sister cities: Hangzhou (China), Cincinnati, Ohio, Cincinnati (United States) and Florence (Italy).GPU: Brief History . Gifu Pharmaceutical University. Accessed January 21, 2008. It has had a sister university agreement with Zhejiang University in Hangzhou since 1984. Since then, it has set up exchange programs with the pharmacy programs at the University of Cincinnati in Ohio and the University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UPR Simplified JPEG
UPR may refer to: *Unfolded protein response, a biological response in the endoplasmic reticulum when some proteins did not properly fold. *Union Pacific Railroad, a freight railroad based in Omaha, Nebraska. *Universal Periodic Review of the United Nations Human Rights Council *Unconditional positive regard, one of the three core conditions of Person-centered_therapy *Utah Public Radio, a radio station, part of the College of Humanities and Social Sciences at Utah State University. Politics *Unia Polityki Realnej, a political party in Poland * Popular Republican Union (1919) (french: Union populaire républicaine, UPR) was a Christian democratic party in Alsace, France during the Third Republic. Founded in 1919, the UPR became the dominant party in Alsace during the Interwar era. *Popular Republican Union of Gironde (French: ''Union Populaire Républicaine de la Gironde'', UPR) was a Christian democratic party in Gironde, France during the Third Republic. *Popular Republica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Physiology Or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Susumu Tonegawa
is a Japanese scientist who was the sole recipient of the Nobel Prize for Physiology or Medicine in 1987 for his discovery of V(D)J recombination, the Genetics, genetic mechanism which produces antibody diversity. Although he won the Nobel Prize for his work in immunology, Tonegawa is a molecular biology, molecular biologist by training and he again changed fields following his Nobel Prize win; he now studies neuroscience, examining the molecular, cellular and neuronal basis of memory formation and retrieval. Early life and education Tonegawa was born in Nagoya, Japan and attended Hibiya High School in Tokyo. While a student at Kyoto University, Tonegawa became fascinated with operon theory after reading papers by François Jacob and Jacques Monod, whom he credits in part for inspiring his interest in molecular biology. Tonegawa graduated from Kyoto University in 1963 and, due to limited options for molecular biology study in Japan at the time, moved to the University of Californi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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