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NM_007348

NM_001081304

RefSeq (protein)

NP_031374

NP_001074773

Location (UCSC) Chr 1: 161.77 – 161.96 Mb Chr 1: 170.7 – 170.87 Mb PubMed search [3] [4] Wikidata
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Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[5][6][7] and is involved in the unfolded protein response.

Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

Interactions

ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118217 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026663 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
  6. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347Freely accessible. PMID 9271374. 
  7. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018. 
  8. ^ "Entrez Gene: ATF6 activating transcription factor 6". 
  9. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. PMC 85959Freely accessible. PMID 10866666. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.