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Kampo List
Kampō (or Kanpō, 漢方) medicine is the Japanese study and adaptation of Traditional Chinese medicine. Today in Japan, Kampo is integrated into the national health care system. In 1967, the Ministry of Health, Labour and Welfare approved 4 kampo medicines for reimbursement under the National Health Insurance (NHI) program. In 1976, 82 kampo medicines were approved by the Ministry of Health, Labour and Welfare. Currently, 148 kampo medicines are approved for reimbursement Rather than modifying formulas as in Traditional Chinese medicine, the Japanese kampo tradition uses fixed combinations of herbs in standardized proportions according to the classical literature of Chinese medicine. Kampo medicines are produced by various manufacturers. However, each medicine is composed of exactly the same ingredients under the Ministry of Health, Labour and Welfare (Japan), Ministry's standardization methodology. The medicines are therefore prepared under strict manufacturing conditions that r ...
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Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans Japanese archipelago, an archipelago of List of islands of Japan, 6852 islands covering ; the five main islands are Hokkaido, Honshu (the "mainland"), Shikoku, Kyushu, and Okinawa Island, Okinawa. Tokyo is the Capital of Japan, nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto. Japan is the List of countries and dependencies by population, eleventh most populous country in the world, as well as one of the List of countries and dependencies by population density, most densely populated and Urbanization by country, urbanized. About three-fourths of Geography of Japan, the c ...
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Liu Wei Di Huang Wan
Liu Wei Di Huang Wan, also known as Liuwei Dihuang teapills () or Six Flavor Rehmanni, is a prescription (方剂 fāng jì) in traditional Chinese medicine and pharmacy to treat yin deficiency. In Japanese kampo, it is known as "Rokumi-gan" (六味丸 ろくみがん) (it is also known as Kampo #87). It is commonly made into Chinese patent medicine. History The formula was created by Qian Yi as dihuang pill (地黄丸). It was published in "Xiao'er Yao Zheng Zhi Jue" (also known as "Key to Therapeutics of Children's Diseases" or "The Correct Execution of Pediatric Medicinals and Patterns" ) in 1119 by Qian Yi's student. The formula was altered slightly when it was borrowed as a Japanese kampo formula. Some Chinese species of herbs were replaced with herbs found in Japan. For example, ''Alisma plantago-aquatica'' was replaced with ''Alisma orientale'' for zé xiè. Derivatives The Liuwei Dihuang Wan is one of the most important Chinese patent medicines, and is widely used in e ...
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Chinese Patent Medicine
Chinese patent medicine () are herbal medicines in Traditional Chinese medicine, modernized into a ready-to-use form such as tablets, oral solutions or dry suspensions, as opposed to herbs that require cooking (hot water extraction). Description Chinese patent medicines generally consist of extracted condensed pills called teapills, and are usually small, spherical, and black. They are called teapills because the herbs are cooked into an herbal tea to make the pills. Honey or water pills made from ground raw herbs are also a popular format in China, and they tend to be larger and are slightly to significantly softer than teapills. Modern teapills are created from herbs extracted in stainless steel extractors to create either a water decoction or water-alcohol decoction, depending on the herbs used. They are extracted at a low temperature (below 100 degrees Celsius; 212 degrees Fahrenheit) to preserve essential ingredients. The extracted liquid is then further condensed and a smal ...
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Paeonia Lactiflora
''Paeonia lactiflora'' (Chinese peony, Chinese herbaceous peony, or common garden peony) is a species of herbaceous perennial flowering plant in the family Paeoniaceae, native to central and eastern Asia from eastern Tibet across northern China to eastern Siberia. Description It is tall and broad, with 9-lobed leaves long. The flower buds appear in late spring (May in the Northern Hemisphere). They are large and round, opening into fragrant, cup- or bowl-shaped flowers in diameter, with 5–10 white, pink, or crimson petals and yellow stamens. The plant attracts butterflies. Its habitats include dry open stony slopes, riverbanks and sparse woodland edges. Background ''Paeonia lactiflora'' was known as the white peony (''P. albiflora'') when first introduced into Europe. It was brought to England in the mid-18th century, and is the parent of most modern varieties. It has been grown as an ornamental in China since the 7th century. The Latin specific epithet ''lactiflor ...
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Ginger
Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice A spice is a seed, fruit, root, bark, or other plant substance primarily used for flavoring or coloring food. Spices are distinguished from herbs, which are the leaves, flowers, or stems of plants used for flavoring or as a garnish. Spice ... and a folk medicine. It is a herbaceous perennial plant, perennial which grows annual pseudostems (false stems made of the rolled bases of leaves) about one meter tall bearing narrow leaf blades. The inflorescences bear flowers having pale yellow petals with purple edges, and arise directly from the rhizome on separate shoots. Ginger is in the family (taxonomy), family Zingiberaceae, which also includes turmeric (''Curcuma longa''), cardamom (''Elettaria cardamomum''), and galangal. Ginger originated in Maritime Southeast Asia and was likely domesticated first by the Austronesian peoples. It was transported with ...
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Glycyrrhiza
''Glycyrrhiza'' is a genus of about 20 accepted species in the legume family (Fabaceae), with a subcosmopolitan distribution in Asia, Australia, Europe, and the Americas. The genus is best known for liquorice (British English; licorice in American English), ''G. glabra'', a species native to Eurasia and North Africa, from which most confectionery liquorice is produced. Species Species include: *'' Glycyrrhiza acanthocarpa'' *'' Glycyrrhiza aspera'' *'' Glycyrrhiza astragalina'' *'' Glycyrrhiza bucharica'' *''Glycyrrhiza echinata'' *'' Glycyrrhiza eglandulosa'' *''Glycyrrhiza foetida'' *''Glycyrrhiza foetidissima'' *''Glycyrrhiza glabra'' – liquorice, licorice *'' Glycyrrhiza gontscharovii'' *''Glycyrrhiza iconica'' *''Glycyrrhiza inflata'' *''Glycyrrhiza korshinskyi'' *''Glycyrrhiza lepidota'' – American licorice *''Glycyrrhiza pallidiflora'' *''Glycyrrhiza squamulosa'' *''Glycyrrhiza triphylla'' *''Glycyrrhiza uralensis'' *''Glycyrrhiza yunnanensis ''Glycyrrhiza yunnane ...
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Seirogan
is a pharmaceutical drug marketed in Japan, sold as a treatment of the digestive tract (especially as an antidiarrhoeal), whose main active ingredient is "wood creosote" (also wood-tar creosote, or beechwood creosote). The name is nominally a registered trademark of based in Suita, Osaka which is still the major market-share holder, but the enforceability of the tradename has been voided by the Supreme Court of Japan, which ruled ''seirogan'' to be a common generic name. The ruling only recognizes proprietary use of the bugle logo by Taiko,, pp. 131-; discusses bugle as only recognized trademark; mentions a site that collected 26 different similar looking seirogan brand boxes; on p. 134 is a gallery of 20 different such boxes. but not protection of its characteristic packaging. As a result, dozens of extremely similar packaged drugs are being manufactured and sold in the market. Overview Seirogan is a general-use medicine, mainly to treat the gastro-intestinal system. It cont ...
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Tablet (pharmacy)
A tablet (also known as a pill) is a pharmaceutical oral dosage form (''oral solid dosage'', or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. Tablets are prepared either by molding or by compression. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf li ...
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Takeda Pharmaceuticals
The is a Japanese multinational pharmaceutical company, with partial American and British roots. It is the largest pharmaceutical company in Asia and one of the top 20 largest pharmaceutical companies in the world by revenue (top 10 following its merger with Shire). The company has over 49,578 employees worldwide and achieved US$19.299 billion in revenue during the 2018 fiscal year. The company is focused on oncology, rare diseases, neuroscience, gastroenterology, plasma-derived therapies and vaccines. Its headquarters is located in Chuo-ku, Osaka, and it has an office in Nihonbashi, Chuo, Tokyo. In January 2012, Fortune Magazine ranked the Takeda Oncology Company as one of the 100 best companies to work for in the United States. As of 2015, Christophe Weber was appointed as the CEO and president of Takeda. History Founding and initial acquisitions (1781-2010) Takeda Pharmaceuticals was founded in 1781, and was incorporated on January 29, 1925. One of the firm's ma ...
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Sustained Release
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release R, XR, XLdosage) or to a specific target in the body (targeted-release dosage).Pharmaceutics: Drug Delivery and Targeting
p. 7-13
Sustained-release dosage forms are s designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentrati ...
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Eucalyptol
Eucalyptol is a monoterpenoid. A colorless liquid, it is a bicyclic ether. Eucalyptol has a fresh mint-like smell and a spicy, cooling taste. It is insoluble in water, but miscible with organic solvents. Eucalyptol makes up ~70% - 90% of eucalyptus oil. Eucalyptol forms crystalline adducts with hydrohalic acids, ''o''-cresol, resorcinol, and phosphoric acid. Formation of these adducts is useful for purification. In 1870, F. S. Cloez identified and ascribed the name "eucalyptol" to the dominant portion of ''Eucalyptus globulus'' oil. Uses Because of its pleasant, spicy aroma and taste, eucalyptol is used in flavorings, fragrances, and cosmetics. Cineole-based eucalyptus oil is used as a flavouring at low levels (0.002%) in various products, including baked goods, confectionery, meat products, and beverages. In a 1994 report released by five top cigarette companies, eucalyptol was listed as one of the 599 additives to cigarettes. It is claimed to be added to improve the f ...
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Menthol
Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1''R'',2''S'',5''R'') configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak κ-opioid receptor agonist. Structure Natural menthol exists as one pure stereoisomer, nearly always the (1''R'',2''S'',5''R'') form (bottom left corner of the diagram below). The eight possible stereoisomers are: : In the natural compound, the isopropyl group is in the ''trans'' orientation to both the methyl and hydroxyl groups. Thus, it can be drawn in any of the ways shown: : The (+)- and (−)-enantiomers of menthol are the most stable among ...
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