KDEL (amino Acid Sequence)
KDEL is a target peptide sequence in mammals and plants located on the C-terminal end of the amino acid structure of a protein. The KDEL sequence prevents a protein from being secreted from the endoplasmic reticulum (ER) and facilitates its return if it is accidentally exported. A protein with a functional KDEL motif will be retrieved from the Golgi apparatus by retrograde transport to the ER lumen. It also targets proteins from other locations (such as the cytoplasm) to the ER. Proteins can only leave the ER after this sequence has been cleaved off. The abbreviation KDEL is formed by the corresponding letters to each amino acid. This letter system was defined by the IUPAC and IUBMB in 1983, and is as follows: *K—Lysine *D—Aspartic acid *E—Glutamic acid *L—Leucine Therefore, the KDEL sequence in three letter code is: Lysine, Lys-Aspartic acid, Asp-Glutamic acid, Glu-Leucine, Leu. The soluble resident protein will remain in the ER as long as it contains a KDEL signal seq ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Target Peptide
Target may refer to: Physical items * Shooting target, used in marksmanship training and various shooting sports ** Bullseye (target), the goal one for which one aims in many of these sports ** Aiming point, in field artillery, fixed at a specific target * Color chart (or reference card), the reference target used in digital imaging for accurate color reproduction Places * Target, Allier, France * Target Lake, a lake in Minnesota Terms * Target market, marketing strategy ** Target audience, intended audience or readership of a publication, advertisement, or type of message * In mathematics, the target of a function is also called the codomain * Target (cricket), the total number of runs a team needs to win People * Target (rapper), stage name of Croatian hip-hop artist Nenad Šimun * DJ Target, stage name of English grime DJ Darren Joseph, member of Roll Deep * Gui-Jean-Baptiste Target (1733–1807), French lawyer Art and media * The Target, a comic book charact ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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HDEL (amino Acid Sequence)
HDEL is a target peptide sequence in plants and yeasts located on the C-terminal end of the amino acid structure of a protein. The HDEL sequence prevents a protein from being secreted from the endoplasmic reticulum (ER) and facilitates its return if it is accidentally exported. The similar sequence KDEL performs the same function in animals, while plants are known to utilize both KDEL and HDEL signaling sequences.{{cite journal, author1=Denecke J., author2=De Rycke R., author3=Botterman J., date=Jun 1992, title=Plant and mammalian sorting signals for protein retention in the endoplasmic reticulum contain a conserved epitope., journal=EMBO Journal, volume=11, issue=6, pages=2345–2355, doi=10.1002/j.1460-2075.1992.tb05294.x, pmc=556702, pmid=1376250 The abbreviation HDEL is as follows. * H—Histidine * D—Aspartic acid * E—Glutamic acid * L—Leucine Three letter code is: His His or HIS may refer to: Computing * Hightech Information System, a Hong Kong graphics card com ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Amino Acids
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha amino acids appear in the genetic code. Amino acids can be classified according to the locations of the core structural functional groups, as Alpha and beta carbon, alpha- , beta- , gamma- or delta- amino acids; other categories relate to Chemical polarity, polarity, ionization, and side chain group type (aliphatic, Open-chain compound, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acid '' residues'' form the second-largest component (water being the largest) of human muscles and other tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis. It is thought that they played a key role in enabling lif ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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KDELR3
ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the ''KDELR3'' gene. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys- asp- glu- leu ( KDEL) in animal cells and his-asp-glu-leu ( HDEL) in ''S. cerevisiae''. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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KDELR2
ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the ''KDELR2'' gene. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys- asp- glu- leu ( KDEL) in animal cells and his-asp-glu-leu ( HDEL) in ''S. cerevisiae''. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. See also *KDELR1 *KDELR3 ER lum ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, also known as KDELR1, is a protein which in humans is encoded by the ''KDELR1'' gene. Function Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis- Golgi or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys- asp- glu- leu ( KDEL) in animal cells and his-asp-glu-leu ( HDEL) in ''S. cerevisiae''. This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein and then returns it to the ER. In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identi ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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KKXX (amino Acid Sequence)
KKXX and for some proteins XKXX is a target peptide motif located in the C terminus in the amino acid structure of a protein responsible for retrieval of endoplasmic reticulum (ER) membrane proteins to and from the Golgi apparatus. These ER membrane proteins are transmembrane proteins that are then embedded into the ER membrane after transport from the Golgi. This motif is exclusively cytoplasmic and interacts with the COPI protein complex to target the ER from the ''cis'' end of the Golgi apparatus by retrograde transport. The abbreviation KKXX is formed by the corresponding standard abbreviations for lysine (K) and any amino acid (X). This letter system was defined by the IUPAC and IUBMB in 1983, and is as follows: *K—Lysine *K—Lysine *X— any amino acid *X— any amino acid See also * ER retention * KDEL (amino acid sequence) KDEL is a target peptide sequence in mammals and plants located on the C-term ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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ER Retention
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting signals. The classical ER retention signal is the C-terminal KDEL sequence for lumen bound proteins and KKXX (signal sequence is located in cytoplasm) for transmembrane localization. These signals allow for retrieval from the Golgi apparatus by ER retention receptors, effectively maintaining the protein in the ER. Other mechanisms for ER retention are being studied but are not as well characterized as signal retention. ER retention receptors proteins *KDELR1 *KDELR2 *KDELR3 See also * KKXX (amino acid sequence) * KDEL (amino acid sequence) * Signal peptide *Protein targeting :''This article deals with protein targeting in eukaryotes unless ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Histidine
Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO− form under biological conditions), and an imidazole side chain (which is partially protonated), classifying it as a positively charged amino acid at physiological pH. Initially thought essential only for infants, it has now been shown in longer-term studies to be essential for adults also. It is encoded by the codons CAU and CAC. Histidine was first isolated by Albrecht Kossel and Sven Gustaf Hedin in 1896. It is also a precursor to histamine, a vital inflammatory agent in immune responses. The acyl radical is histidyl. Properties of the imidazole side chain The conjugate acid (protonated form) of the imidazole side chain in histidine has a p''K''a of approximately 6.0. Thus, below a pH of 6, the imidazole ring ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Plant
Plants are predominantly photosynthetic eukaryotes of the kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all current definitions of Plantae exclude the fungi and some algae, as well as the prokaryotes (the archaea and bacteria). By one definition, plants form the clade Viridiplantae (Latin name for "green plants") which is sister of the Glaucophyta, and consists of the green algae and Embryophyta (land plants). The latter includes the flowering plants, conifers and other gymnosperms, ferns and their allies, hornworts, liverworts, and mosses. Most plants are multicellular organisms. Green plants obtain most of their energy from sunlight via photosynthesis by primary chloroplasts that are derived from endosymbiosis with cyanobacteria. Their chloroplasts contain chlorophylls a and b, which gives them their green color. Some plants are parasitic or mycotrophic and have lost the ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Yeast
Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to constitute 1% of all described fungal species. Yeasts are unicellular organisms that evolved from multicellular ancestors, with some species having the ability to develop multicellular characteristics by forming strings of connected budding cells known as pseudohyphae or false hyphae. Yeast sizes vary greatly, depending on species and environment, typically measuring 3–4 µm in diameter, although some yeasts can grow to 40 µm in size. Most yeasts reproduce asexually by mitosis, and many do so by the asymmetric division process known as budding. With their single-celled growth habit, yeasts can be contrasted with molds, which grow hyphae. Fungal species that can take both forms (depending on temperature or other conditions) are ca ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |