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Joshua Boger
Joshua S. Boger (born April 12, 1951) is an organic chemist and the founder of Vertex Pharmaceuticals Incorporated. He is considered a pioneer in the field of structure-based rational drug design. Drugs developed include amprenavir, an HIV protease inhibitor; telaprevir, a protease inhibitor for treatment of hepatitis C; and Kalydeco, for the treatment of cystic fibrosis. In 2003, Vertex was listed as one of forty worldwide Technology Pioneers by the World Economic Forum. As of 2012, Boger became executive chairman of Alkeus Pharmaceuticals. Childhood Joshua S. Boger was born on April 12, 1951, in Concord, North Carolina to Charles E. Boger, Jr., a textile chemist and Mary Snead Boger, an actress and writer. Education From 1970 to 1973, Boger attended Wesleyan University. During this time Max Tishler, formerly the president of Merck Sharp and Dohme Research Laboratories, became Boger's mentor. Boger received a bachelor's degree in chemistry and philosophy from Wesleyan in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Concord, North Carolina
Concord is the county seat and largest city in Cabarrus County, in the U.S. state of North Carolina. As of the 2020 census, the city had a population of 105,186, with an estimated population in 2021 of 107,697. In terms of population, the city of Concord is the second-largest city in the Charlotte metropolitan area and is the 10th most populous city in North Carolina and 287th most populous city in the U.S. The city was a winner of the All-America City Award in 2004. Located near the center of Cabarrus County in the Piedmont region, it is northeast of Uptown Charlotte. Concord is the home to some of North Carolina's top tourist destinations, including NASCAR's Charlotte Motor Speedway and Concord Mills. History Concord, located in today's rapidly growing northeast quadrant of the Charlotte metropolitan area, was first settled about 1750 by German and Scots-Irish immigrants. The name Concord means with harmony. This name was chosen after a lengthy dispute between the Ger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Tishler
Max Tishler (October 30, 1906 – March 18, 1989) was president of Merck Sharp and Dohme Research Laboratories where he led the research teams that synthesized ascorbic acid, riboflavin, cortisone, pyridoxine, pantothenic acid, nicotinamide, methionine, threonine, and tryptophan. He also developed the fermentation processes for actinomycin, vitamin B12, streptomycin, and penicillin. Tishler invented sulfaquinoxaline for the treatment for coccidiosis. Biography He was born in Boston, Massachusetts on October 30, 1906. His father repaired shoes and he abandoned the family in 1911. Max worked in a pharmacy during the flu pandemic of 1918. He studied chemistry as an undergraduate at Tufts College, where he was a member of the Pi Lambda Phi fraternity. In 1934 he earned his Ph.D. in organic chemistry from Harvard University. He married Elizabeth M. Verveer in 1934. He taught at Harvard from 1934 to 1937. His son, Peter Verveer Tishler, was born on July 18, 1937. In 1937, he too ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GlaxoSmithKline
GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tenth largest pharmaceutical company and #294 on the 2022 ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. , it had a market capitalisation of £70 billion, the eighth largest on the London Stock Exchange. It has a secondary listing on the New York Stock Exchange. The company developed the first malaria vaccine, RTS,S, which it said in 2014 it would make available for five percent above cost. Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Molecule
Within the fields of molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs are small molecules; the terms are equivalent in the literature. Larger structures such as nucleic acids and proteins, and many polysaccharides are not small molecules, although their constituent monomers (ribo- or deoxyribonucleotides, amino acids, and monosaccharides, respectively) are often considered small molecules. Small molecules may be used as research tools to probe biological function as well as leads in the development of new therapeutic agents. Some can inhibit a specific function of a protein or disrupt protein–protein interactions. Pharmacology usually restricts the term "small molecule" to molecules that bind specific biological macromolecules and act as an effector, altering the activity or function of the target. Small ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renin Inhibitor
Renin inhibitors are pharmaceutical drugs inhibiting the activity of renin that is responsible for hydrolyzing angiotensinogen to angiotensin I, which in turn reduces the formation of angiotensin II that facilitates blood pressure. Renin inhibitor is often preceded by ''direct'', called ''direct'' renin inhibitor in order to distinguish its mechanism from other renin–angiotensin–aldosterone system-interfering drugs such as angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs) and aldosterone receptor antagonists. These drugs inhibit the first and rate-limiting step of the renin–angiotensin–aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I. This leads to a totality in absence of angiotensin II based on the rationale that renin only acts to inhibit this step unlike Angiotensin Converting Enzyme which is also involved in other biochemical reactions. Since the 1970s, scientists have been trying to develop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high blood pressure, however, is a major risk factor for stroke, coronary artery disease, heart failure, atrial fibrillation, peripheral arterial disease, vision loss, chronic kidney disease, and dementia. Hypertension is a major cause of premature death worldwide. High blood pressure is classified as primary (essential) hypertension or secondary hypertension. About 90–95% of cases are primary, defined as high blood pressure due to nonspecific lifestyle and genetic factors. Lifestyle factors that increase the risk include excess salt in the diet, excess body weight, smoking, and alcohol use. The remaining 5–10% of cases are categorized as secondary high blood pressure, defined as high blood pressure due to an identifiable cause, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strasbourg, France
Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian dialect, Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian dialect, Alsatian, Strossburig ) is the Prefectures in France, prefecture and largest city of the Grand Est Regions of France, region of Geography of France, eastern France and the Seat of the European Parliament in Strasbourg, official seat of the European Parliament. Located at the France–Germany border, border with Germany in the historic region of Alsace, it is the prefecture of the Bas-Rhin Departments of France, department. In 2019, the city proper had 287,228 inhabitants and both the Eurométropole de Strasbourg (Greater Strasbourg) and the Arrondissement of Strasbourg had 505,272 inhabitants. Strasbourg's functional area (France), metropolitan area had a population of 846,450 in 2018, making it the eighth-largest metro area in France and home to 14% of the Grand Est region's inhabitants. The transnational Eurodistrict Strasbourg-Ortenau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Université Louis Pasteur
Louis Pasteur University (''Université Louis-Pasteur''), also known as Strasbourg I or ULP was a large university in Strasbourg, Alsace, France. As of 15 January 2007, there were 18,847 students enrolled at the university, including around 3,000 foreign students. Research and teaching at ULP concentrated on the natural sciences, technology and medicine. On 1 January 2009, Louis Pasteur University became part of the refounded University of Strasbourg and lost its status as an independent university. The university was a member of the LERU (League of European Research Universities). It was named after the famous 19th-century French scientist Louis Pasteur. Nineteen Nobel laureates and two laureates of the Fields Medal have studied, taught or conducted research at Louis Pasteur University, underlining the excellent reputation of the university. Notable staff and students * Louis Pasteur (1822–1895), professor of chemistry * Adolf von Baeyer (1835–1917), professor of chemistr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jean-Marie Lehn
Jean-Marie Lehn (born 30 September 1939) is a French chemist. He received the Nobel Prize in Chemistry together with Donald Cram and Charles Pedersen in 1987 for his synthesis of cryptands. Lehn was an early innovator in the field of supramolecular chemistry, i.e., the chemistry of host–guest molecular assemblies created by intermolecular interactions, and continues to innovate in this field. his group has published 790 peer-reviewed articles in chemistry literature. Biography Early years Lehn was born in Rosheim, Alsace, France to Pierre and Marie Lehn. He is of Alsatian German descent. His father was a baker, but because of his interest in music, he later became the city organist. Lehn also studied music, saying that it became his major interest after science. He has continued to play the organ throughout his professional career as a scientist. His high school studies in Obernai, from 1950 to 1957, included Latin, Greek, German, and English languages, French literatur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Recognition
The term molecular recognition refers to the specific interaction between two or more molecules through noncovalent bonding such as hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions, halogen bonding, or resonant interaction effects. In addition to these ''direct'' interactions, solvents can play a dominant ''indirect'' role in driving molecular recognition in solution. The host and guest involved in molecular recognition exhibit molecular complementarity. Exceptions are molecular containers, including e.g. nanotubes, in which portals essentially control selectivity. Biological systems Molecular recognition plays an important role in biological systems and is observed in between receptor-ligand, antigen-antibody, DNA-protein, sugar- lectin, RNA-ribosome, etc. An important example of molecular recognition is the antibiotic vancomycin that selectively binds with the peptides with terminal D-alanyl-D-alanine in bacterial cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclodextrin
Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds. Cyclodextrins are produced from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental engineering. Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape: * α (alpha)-cyclodextrin: 6 glucose subunits * β (beta)-cyclodextrin: 7 glucose subunits * γ (gamma)-cyclodextrin: 8 glucose subunits The largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units. Poorly-characterized mixtures, containing at least 150-membered cyclic oligosaccharides are also known. Applications Drug delivery Cyclodextrins are ingredients in more than 30 d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeremy R
{{disambiguation ...
Jeremy may refer to: * Jeremy (given name), a given name * Jérémy, a French given name * ''Jeremy'' (film), a 1973 film * "Jeremy" (song), a song by Pearl Jam * Jeremy (snail), a left-coiled garden snail that died in 2017 * ''Jeremy'', a 1919 novel by Hugh Walpole See also * * * Jeremiah (other) * Jeremie (other) * Jerome (other) * Jeromy (other) Jeromy may refer to: * Jeromy Burnitz, American former professional baseball player * Jeromy Carriere, Canadian computer software engineer * Jeromy Cox, American colorist * Jeromy Farkas, American politician * Jeromy James, Belizean footballer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
