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GLAXOSMITHKLINE PLC (GSK) is a British pharmaceutical company headquartered in Brentford , London. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham, GSK was the world's sixth largest pharmaceutical company as of 2015, after Pfizer , Novartis
Novartis
, Merck , Hoffmann-La Roche and Sanofi
Sanofi
. Emma Walmsley became CEO on 31 March 2017 and is the first female CEO of the company.

The company has a primary listing on the London Stock Exchange
London Stock Exchange
and is a constituent of the FTSE 100 Index
FTSE 100 Index
. As of August 2016 it had a market capitalisation of £81 billion (around $107 billion), the fourth largest on the London
London
Stock Exchange. It has a secondary listing on the New York Stock Exchange .

GSK's drugs and vaccines earned £21.3 billion in 2013. Its top-selling products that year were Advair , Avodart , Flovent , Augmentin
Augmentin
, Lovaza and Lamictal . GSK's consumer products, which earned £5.2 billion in 2013, include Sensodyne and Aquafresh toothpaste, the malted-milk drink Horlicks , Abreva for cold sores, Breathe Right nasal strips , Nicoderm and Nicorette nicotine replacements, and Night Nurse, a cold remedy. The company developed the first malaria vaccine , RTS,S , which it said in 2014 it would make available for five percent above cost. Legacy products developed at GSK include several listed in the World Health Organization Model List of Essential Medicines , such as amoxicillin , mercaptopurine , pyrimethamine and zidovudine .

In 2012, GSK pleaded guilty to promotion of drugs for unapproved uses, failure to report safety data, and kickbacks to physicians in the United States and agreed to pay a $3 billion (£1.9bn) settlement, the largest settlement in the country by a drug company.

CONTENTS

* 1 History

* 1.1 Glaxo Wellcome * 1.2 SmithKline Beecham * 1.3 GlaxoSmithKline
GlaxoSmithKline
* 1.4 Venture arms

* 2 Research, products

* 2.1 Pharmaceuticals * 2.2 Malaria vaccine * 2.3 Consumer healthcare * 2.4 Facilities * 2.5 Scientific recognition

* 3 Operations and acquisitions since 2001

* 3.1 2001–2010 * 3.2 2011–present

* 4 Philanthropy and social responsibility

* 5 2012 criminal and civil settlement

* 5.1 Overview * 5.2 Rosiglitazone (Avandia) * 5.3 Paroxetine
Paroxetine
(Paxil/Seroxat) * 5.4 Bupropion
Bupropion
(Wellbutrin)

* 6 Other controversies

* 6.1 Antitrust case over griseofulvin * 6.2 Ribena * 6.3 SB Pharmco Puerto Rico
Puerto Rico
* 6.4 China * 6.5 Market manipulation in the UK * 6.6 Miscellaneous

* 7 Diagram of acquisition history * 8 See also * 9 Notes * 10 References * 11 External links

HISTORY

GLAXO WELLCOME

The historic Glaxo factory in Bunnythorpe, New Zealand , with the Glaxo Laboratories sign still visible

Glaxo was founded in the 1850s as a general trading company in Bunnythorpe , New Zealand, by a Londoner, Joseph Edward Nathan . In 1904 it began producing dried-milk baby food, first known as Defiance, then as Glaxo (from _lacto_), under the slogan "Glaxo builds bonny babies." :306 The Glaxo Laboratories sign is still visible _(right)_ on what is now a car repair shop on the main street of Bunnythorpe. The company's first pharmaceutical product, produced in 1920, was vitamin D. :306

Glaxo Laboratories opened new units in London
London
in 1935. The company bought two companies, Joseph Nathan and Allen & Hanburys in 1947 and 1958 respectively. The Scottish pharmacologist David Jack was working for Allen he went on to lead the company's R">:306 After the company bought Meyer Laboratories in 1978, it began to play an important role in the US market. In 1983 the American arm, Glaxo Inc., moved to Research Triangle Park (US headquarters/research) and Zebulon (US manufacturing) in North Carolina.

Burroughs Wellcome ">:18 which served as the US headquarters until the company moved to Research Triangle Park in North Carolina in 1971. The Nobel Prize winning scientists Gertrude B. Elion and George H. Hitchings worked there and invented drugs still used many years later, such as mercaptopurine . In 1959 the Wellcome Company bought Cooper, McDougall ">:309 Glaxo restructured its R&D operation that year, cutting 10,000 jobs worldwide, closing its R&D facility in Beckenham, Kent, and opening a Medicines Research Centre in Stevenage, Hertfordshire. Also that year, Glaxo Wellcome acquired the California-based Affymax, a leader in the field of combinatorial chemistry .

By 1999 Glaxo Wellcome had become the world's third-largest pharmaceutical company by revenues (behind Novartis
Novartis
and Merck), with a global market share of around 4 per cent. Its products included Imigran (for the treatment of migraine), salbutamol (Ventolin) (for the treatment of asthma), Zovirax (for the treatment of coldsores), and Retrovir and Epivir (for the treatment of AIDS). In 1999 the company was the world's largest manufacturer of drugs for the treatment of asthma and HIV/AIDS. It employed 59,000 people, including 13,400 in the UK, had 76 operating companies and 50 manufacturing facilities worldwide, and seven of its products were among the world's top 50 best-selling pharmaceuticals. The company had R&D facilities in Hertfordshire, Kent and London, and manufacturing plants in Scotland and the north of England. It had R"> Beecham's Clock Tower, constructed 1877, part of the Beecham 's factory, St Helens

In 1843 Thomas Beecham launched his Beecham\'s Pills laxative in England, giving birth to the Beecham Group . In 1859 Beecham opened its first factory in St Helens , Lancashire
Lancashire
. By the 1960s Beecham was extensively involved in pharmaceuticals.

John K. Smith opened his first pharmacy in Philadelphia
Philadelphia
in 1830. In 1865 Mahlon Kline joined the business, which 10 years later became Smith, Kline & Co. In 1891 it merged with French, Richard and Company, and in 1929 changed its name to Smith Kline & French Laboratories as it focused more on research. Years later it bought Norden Laboratories, a business doing research into animal health, and Recherche et Industrie Thérapeutiques in Belgium in 1963 to focus on vaccines. The company began to expand globally, buying seven laboratories in Canada and the United States in 1969. In 1982 it bought Allergan , a manufacturer of eye and skincare products.

SmithKline & French merged with Beckman Inc. in 1982 and changed its name to _SmithKline Beckman_. In 1988 it bought its biggest competitor, International Clinical Laboratories, and in 1989 merged with Beecham to form _SmithKline Beecham Plc_. The headquarters moved from the United States to England. To expand R another opened in 1997 in England at New Frontiers Science Park, Harlow
Harlow
.

GLAXOSMITHKLINE

Glaxo Wellcome and SmithKline Beecham announced their intention to merge in January 2000. The merger was completed in December that year, forming GlaxoSmithKline
GlaxoSmithKline
(GSK). The company's global headquarters are at GSK House, Brentford , London, officially opened in 2002 by then-Prime Minister Tony Blair
Tony Blair
. The building was erected at a cost of £300 million and as of 2002 was home to 3,000 administrative staff.

VENTURE ARMS

SR One was established in 1985 by SmithKline Beecham to invest in new biotechnology companies and continued operating after GSK was formed; by 2003 GSK had formed another subsidiary, GSK Ventures, to out-license or start new companies around drug candidates that it did not intend to develop further. As of 2003, SR One tended to invest only if the company aligned with GSK's business.

SR One was led by:

* 1985 to 1999: Peter Sears * 1999 to 2001: Brenda Gavin * 2001 to 2003: Barbara Dalton * 2004 to ? Maxine Gowen * ? to ?: Joyce Lonergan * ? to ?: Tamar Howson * 2008 to 2010: Russell Greig * 2010 to 2011: Christoph Westphal * 2011: Jens Eckstein

RESEARCH, PRODUCTS

Further information: List of GlaxoSmithKline products

PHARMACEUTICALS

GSK manufactures products for major disease areas such as asthma, cancer, infections, diabetes and mental health. Its biggest-selling in 2013 were Advair , Avodart , Flovent , Augmentin
Augmentin
, Lovaza , and Lamictal ; its drugs and vaccines earned £21.3 billion that year. Other top-selling products include its asthma / COPD inhalers Advair, Ventolin, and Flovent; its diphtheria /tetanus /pertussis vaccine Infanrix and its hepatitis B vaccine ; the epilepsy drug Lamictal , and the antibacterial Augmentin. :220

Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin and amoxicillin-clavulanate , ticarcillin-clavulanate , mupirocin , and ceftazidime for bacterial infections, zidovudine for HIV infection , valacyclovir for herpes virus infections, albendazole for parasitic infections, sumatriptan for migraine , lamotrigine for epilepsy, bupropion and paroxetine for major depressive disorder , cimetidine and ranitidine for gastroesophageal reflux disorder , mercaptopurine and thioguanine for the treatment of leukemia, allopurinol for gout , pyrimethamine for malaria , and the antibacterial trimethoprim .

Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupriocin, pyrimethamine, ranitidine, thioguanine, trimethoprim and zidovudine are listed on the World Health Organization's list of essential medications.

MALARIA VACCINE

In 2014 GSK applied for regulatory approval for the first malaria vaccine . Malaria is responsible for over 650,000 deaths annually, mainly in Africa. Known as RTS,S , the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates Foundation . The company has committed to making the vaccine available in developing countries for five percent above the cost of production.

As of 2013 RTS,S, which uses GSK's proprietary AS01 adjuvant, was being examined in a Phase 3 trial in eight African countries. PATH reported that "n the 12-month period following vaccination, RTS,S conferred approximately 50% protection from clinical Plasmodium falciparum disease in children aged 5-17 months, and approximately 30% protection in children aged 6-12 weeks when administered in conjunction with Expanded Program for Immunization (EPI) vaccines." In 2014 Glaxo said it had spent more than $350 million and expected to spend an additional $260 million before seeking regulatory approval. A second generation malaria vaccine is being evaluated in Phase 2 clinical trials.

CONSUMER HEALTHCARE

GSK's consumer healthcare division, which earned £5.2 billion in 2013, sells oral healthcare, including Aquafresh , Maclean's and Sensodyne toothpastes; and drinks such as Horlicks , Boost and a chocolate-flavoured malt drink sold in India. GSK also previously owned the Lucozade and Ribena brands of soft drinks, but they were sold in 2013 to Suntory for £1.35bn. Other products include Abreva to treat cold sores; Night Nurse, a cold remedy; Breathe Right nasal strips ; and Nicoderm and Nicorette nicotine replacements. In March 2014 it recalled Alli , an over-the-counter weight-loss drug, in the United States and Puerto Rico
Puerto Rico
because of possible tampering, following customer complaints.

FACILITIES

As of 2013 GSK had offices in over 115 countries and employed over 99,000 people, 12,500 in R its consumer-products division is in Moon Township, Pennsylvania . :7 Company facilities include:

* R&D sites: England ( Stevenage
Stevenage
, Stockley Park , Ware ), the US (Research Triangle Park, North Carolina, and Collegeville, Pennsylvania ), Canada, China, Croatia, France and India. GSK is also planning to open a R King of Prussia, Pennsylvania ; Zebulon, North Carolina ), as well as Australia, Belgium, France, Italy, Malaysia, Poland, Puerto Rico, Romania and Singapore. * Manufacturing sites for consumer products: England (Maidenhead), Ireland (Dungarvan), the US (Aiken, South Carolina; Oak Hill, New York; St. Louis, Missouri), Brazil, Canada and Kenya.

SCIENTIFIC RECOGNITION

Four GlaxoSmithKline
GlaxoSmithKline
scientists have been recognized by the Nobel Committee for their contributions to basic medical science and/or therapeutics development.

* Henry Dale , a former student of Paul Ehrlich , received the 1936 Nobel Prize in Medicine for his work on the chemical transmission of neural impulses. Dale served as a pharmacologist and then as Director of the Wellcome Physiological Research Laboratories from 1904 to 1914, and later served as Trustee and Chairman of the Board of the Wellcome Trust . * John Vane of Wellcome Research Laboratories shared the 1982 Nobel Prize for Medicine for his work on prostaglandin biology and the discovery of prostacyclin . Vane served as Group Research and Development Director for The Wellcome Foundation from 1973 to 1985. * Gertrude B. Elion and George Hitchings , both of the Wellcome Research Laboratories, shared the 1988 Nobel Prize in Medicine with Sir James W. Black ""for their discoveries of important principles for drug treatment"." Elliot and Hitchings were responsible for the discovery of a plethora of important drugs, including mercaptopurine and thioguanine for the treatment of leukemia, the immunosuppressant azothioprine, allopurinol for gout, pyrimethamine for malaria, the antibacterial trimethoprim, acyclovir for herpes virus infection, and nelarabine for cancer treatment.

OPERATIONS AND ACQUISITIONS SINCE 2001

2001–2010

Andrew Witty , GSK's CEO since May 2008

GSK completed the acquisition of New Jersey-based Block Drug in 2001 for US$1.24 billion. In 2006 GSK acquired the US-based consumer healthcare company CNS Inc., whose products included Breathe Right nasal strips and FiberChoice dietary supplements, for US$566 million in cash.

Chris Gent , previously CEO of Vodafone
Vodafone
, was appointed chairman of the board in 2005.

GSK opened its first R the companies had collaborated on developing the lupus drug Belimumab (Benlysta), albiglutide for type 2 diabetes , and darapladib for atherosclerosis .

In March 2014 GSK paid $1 billion to raise its stake in its Indian pharmaceutical unit, GlaxoSmithKline
GlaxoSmithKline
Pharmaceuticals, to 75 percent as part of a move to focus on emerging markets. In April 2014 Novartis and Glaxo agreed on more than $20 billion in deals, with Novartis selling its vaccine business to GSK and buying GSK's cancer business. In February 2015 GSK announced that it would acquire GlycoVaxyn, a Swiss pharmaceutical company, for $190 million, and in June that year that it would sell two meningitis drugs to Pfizer , Nimenrix and Mencevax for around $130 million.

Philip Hampton , at that time chair of the Royal Bank of Scotland
Royal Bank of Scotland
, became GSK chairman in September 2015.

In September 2016 the company announced that Witty would be succeeded as CEO by Emma Walmsley in March 2017; Walmsley was a management professional originally from Lancashire
Lancashire
with a background in marketing.

PHILANTHROPY AND SOCIAL RESPONSIBILITY

GlaxoSmithKline, Center City, Philadelphia

Since 2010 GlaxoSmithKline
GlaxoSmithKline
has several times ranked first among pharmaceutical companies on the Global Access to Medicines Index, which is funded by the Bill and Melinda Gates Foundation . In 2014 the Human Rights Campaign
Human Rights Campaign
, an LGBT
LGBT
-rights advocacy group gave GSK a score of 100 percent in its Corporate Equality Index .

GSK has been active, with the World Health Organization (WHO), in the Global Alliance to Eliminate Lymphatic Filariasis
Filariasis
(GAELF). Around 120 million people globally are believed to be infected with lymphatic filariasis . In 2012 the company endorsed the London
London
Declaration on Neglected Tropical Diseases ; it agreed to donate 400 million albendazole tablets to the WHO each year to fight soil-transmitted helminthiasis and to provide 600 million albendazole tablets every year for lymphatic filariasis until the disease is eradicated. As of 2014 over 5 billion treatments had been delivered, and 18 of 73 countries in which the disease is considered endemic had progressed to the surveillance stage.

In 2009 the company said it would cut drug prices by 25 percent in 50 of the poorest nations, release intellectual property rights for substances and processes relevant to neglected disease into a patent pool to encourage new drug development, and invest 20 percent of profits from the least-developed countries in medical infrastructure for those countries. Médecins Sans Frontières welcomed the decision, but criticized GSK for failing to include HIV patents in its patent pool and for not including middle-income countries in the initiative.

In 2013 GSK licensed its HIV portfolio to the Medicines Patent Pool for use in children, and agreed to negotiate a license for dolutegravir , an integrase inhibitor then in clinical development. In 2014 this license was extended to include dolutegravir and adults with HIV. The licenses include countries in which 93 percent of adults and 99 percent of children with HIV live. Also in 2013 GSK joined AllTrials , a British campaign to ensure that all clinical trials are registered and the results reported. The company said it would make its past clinical-trial reports available and future ones within a year of the studies' end.

2012 CRIMINAL AND CIVIL SETTLEMENT

OVERVIEW

In July 2012 GSK pleaded guilty in the United States to criminal charges, and agreed to pay $3 billion, in what was the largest settlement until then between the Justice Department and a drug company. The $3 billion included a criminal fine of $956,814,400 and forfeiture of $43,185,600. The remaining $2 billion covered a civil settlement with the government under the False Claims Act . The investigation was launched largely on the basis of information from four whistleblowers who filed qui tam (whistleblower) lawsuits against the company under the False Claims Act.

The charges stemmed from GSK's promotion of the anti-depressants Paxil (paroxetine ) and Wellbutrin (bupropion ) for unapproved uses from 1998–2003, specifically as suitable for patients under the age of 18, and from its failure to report safety data about Avandia (rosiglitazone ), both in violation of the Federal Food, Drug, and Cosmetic Act . Other drugs promoted for unapproved uses were two inhalers, Advair (fluticasone/salmeterol ) and Flovent (fluticasone propionate ), as well as Zofran (ondansetron ), Imitrex (sumatriptan ), Lotronex (alosetron ) and Valtrex (valaciclovir ).

The settlement also covered reporting false best prices and underpaying rebates owed under the Medicaid Drug Rebate Program , and kickbacks to physicians to prescribe GSK's drugs. There were all-expenses-paid spa treatments and hunting trips for doctors and their spouses, speakers' fees at conferences, and payment for articles ghostwritten by the company and placed by physicians in medical journals. The company set up a ghostwriting programme called CASPPER, initially to produce articles about Paxil but which was extended to cover Avandia.

As part of the settlement GSK signed a five-year Corporate Integrity Agreement with the Department of Health and Human Services , which obliged the company to make major changes in the way it did business, including changing its compensation programmes for its sales force and executives, and to implement and maintain transparency in its research practices and publication policies. It announced in 2013 that it would no longer pay doctors to promote its drugs or attend medical conferences, and that its sales staff would no longer have prescription targets.

ROSIGLITAZONE (AVANDIA)

Further information: Rosiglitazone § Adverse effects , and Rosiglitazone § Lawsuits Rosiglitazone

The 2012 settlement included a criminal fine of $242,612,800 for failing to report safety data to the FDA about Avandia (rosiglitazone ), a diabetes drug approved in 1999, and a civil settlement of $657 million for making false claims about it. The Justice Department said GSK had promoted rosiglitazone to physicians with misleading information, including that it conferred cardiovascular benefits despite an FDA-mandated label warning of cardiovascular risks.

In 1999 John Buse , a diabetes specialist, told medical conferences that rosiglitazone might carry an increased risk of cardiovascular problems. GSK threatened to sue him, called his university head of department, and persuaded him to sign a retraction. GSK raised questions internally about the drug's safety in 2000, and in 2002 the company ghostwrote an article in _Circulation_ describing a GSK-funded clinical trial that suggested rosiglitazone might have a beneficial effect on cardiovascular risk. From 2001 reports began to link the thiazolidinediones (the class of drugs to which rosiglitazone belongs) to heart failure . In April that year GSK began a six-year, open-label , randomized trial , known as RECORD, to examine rosiglitazone and cardiovascular events. Two GSK meta-analyses in 2005 and 2006 showed an increased risk of cardiovascular problems with rosiglitazone; the information was passed to the FDA and posted on the company website, but not otherwise published. By December 2006 rosiglitazone had become the top-selling diabetes drug, with annual sales of US$3.3 billion.

In June 2007 the _New England Journal of Medicine_ published a meta-analysis that associated the drug with an increased risk of heart attack . GSK had reportedly tried to persuade one of the authors, Steven Nissen , not to publish it, after receiving an advance copy from one of the journal's peer reviewers, a GSK consultant. In July 2007 FDA scientists suggested that rosiglitazone had caused 83,000 excess heart attacks between 1999 and 2007. :4 The FDA placed restrictions on the drug, including adding a boxed warning , but did not withdraw it. (In 2013 the FDA rejected that the drug had caused excess heart attacks.) A Senate Finance Committee inquiry concluded in 2010 that GSK had sought to intimidate scientists who had concerns about rosiglitazone. In February that year the company tried to halt publication of an editorial about the controversy by Nissen in the _European Heart Journal_.

The results of GSK's RECORD trial were published in June 2009. It confirmed an association between rosiglitazone and an increased risk of heart failure and fractures, but not of heart attack, and concluded that it "does not increase the risk of overall cardiovascular morbidity or mortality compared with standard glucose-lowering drugs." Steven Nissan and Kathy Wolkski argued that the study's low event rates reduced its statistical power. In September 2009 rosiglitazone was suspended in Europe. The results of the RECORD study were confirmed in 2013 by the Duke Clinical Research Institute, in an independent review required by the FDA. In November that year the FDA lifted the restrictions it had placed on the drug. The boxed warning about heart attack was removed; the warning about heart failure remained in place.

PAROXETINE (PAXIL/SEROXAT)

Main article: Study 329 Paroxetine
Paroxetine
, known as Paxil and Seroxat

GSK was fined for promoting Paxil/Seroxat (paroxetine ) for treating depression in the under-18s, although the drug had not been approved for pediatric use. Paxil had $4.97 billion worldwide sales in 2003. The company conducted nine clinical trials between 1994 and 2002, none of which showed that Paxil helped children with depression. From 1998 to 2003 it promoted the drug for the under-18s, paying physicians to go on all-expenses paid trips, five-star hotels and spas. From 2004 Paxil's label, along with those of similar drugs, included an FDA-mandated boxed warning that it might increase the risk of suicidal ideation and behaviour in patients under 18.

An internal SmithKline Beecham document said in 1998, about withheld data from two GSK studies: "It would be commercially unacceptable to include a statement that efficacy had not been demonstrated, as this would undermine the profile of paroxetine." The company ghostwrote an article, published in 2001 in the _Journal of the American Academy of Child and Adolescent Psychiatry_, that misreported the results of one of its clinical trials, Study 329 . The article concluded that Paxil was "generally well tolerated and effective for major depression in adolescents." The suppression of the research findings is the subject of _Side Effects _ (2008) by Alison Bass .

For 10 years GSK marketed Paxil as non-habit forming. In 2001 35 patients filed a class-action suit alleging they had suffered withdrawal symptoms, and in 2002, a Los Angeles court issued an injunction preventing GSK from advertising that the drug was not habit forming. The court withdrew the injunction after the FDA objected that the court had no jurisdiction over drug marketing that the FDA had approved. In 2003, a World Health Organization committee reported that Paxil was among the top 30 drugs, and top three antidepressants, for which dependence had been reported.

BUPROPION (WELLBUTRIN)

The company was also fined for promoting Wellbutrin (bupropion ) – approved at the time for major depressive disorder and also sold as a smoking-cessation aid, Zyban – for weight loss and the treatment of attention deficit hyperactivity disorder , sexual dysfunction and substance addiction. GSK paid doctors to promote these off-label uses, and set up supposedly independent advisory boards and Continuing Medical Education programmes.

OTHER CONTROVERSIES

ANTITRUST CASE OVER GRISEOFULVIN

In the 1960s Glaxo Group Ltd. (Glaxo) and Imperial Chemical Industries (ICI) each owned patents covering various aspects of the antifungal drug griseofulvin . :54, nn. 1–2 They created a patent pool by cross-licensing their patents, subject to express licensing restrictions that the chemical from which the "finished" form of the drug (tablets and capsules) was made must not be resold in bulk form, and they licensed other drug companies to sell the drug in finished form and subject to similar restrictions. :54–55 The effect and intent of the bulk-sale restriction was to keep the drug chemical out of the hands of small companies that might act as price-cutters, and the effect was to maintain stable, uniform prices.

The United States brought an antitrust suit against the two companies—_ United States v. Glaxo Group Ltd. _—charging them with violation of the Sherman Act and also seeking to have the patents declared invalid. :55 The trial court found that the defendants had engaged in several unlawful conspiracies, but dismissed the part of the suit seeking invalidation of patents and refused to grant as relief mandatory sales of the bulk drug chemical and compulsory licensing of the patents. :56 The government appealed to the Supreme Court, which reversed, in _ United States v. Glaxo Group Ltd. _, 410 U.S. 52 (1973).

RIBENA

Old Ribena bottle, year unknown, made by Beecham Products, Brentford, Middlesex; the label states: "widely used in hospitals and clinics."

There were concerns in the 2000s about the sugar and vitamin content of Ribena , a blackcurrant -based syrup and soft drink owned by GSK until 2013. Produced in England by H.W. Carter Bactroban , used to treat skin infections; Paxil, the anti-depressant; and Avandamet , a diabetes drug. GSK closed the factory in 2009.

According to the _New York Times_, the case began in 2002 when GSK sent experts to fix problems cited by the FDA. The lead inspector recommended recalls of defective products, but they were not authorized; she was fired in 2003 and filed a whistleblower lawsuit. In 2005 federal marshals seized $2 billion worth of products, the largest such seizure in history. In the 2010 settlement SB Pharmco plead guilty to criminal charges, and agreed to pay $150 million in a criminal fine and forfeiture, at that time the largest such payment ever by a manufacturer of adulterated drugs, and $600 million in civil penalties to settle the civil lawsuit.

CHINA

In 2013 Chinese authorities announced that, since 2007, GSK had funnelled HK$3.8 billion in kickbacks to GSK managers, doctors, hospitals and others who prescribed their drugs, using over 700 travel agencies and consulting firms. Chinese authorities arrested four GSK executives as part of a four-month investigation into claims that doctors were bribed with cash and sexual favours. In 2014 a Chinese court found the company guilty of bribery and imposed a fine of $490 million. Mark Reilly, the British head of GSK's Chinese operations, received a three-year suspended prison sentence after a one-day trial held in secret. Reilly was reportedly deported from China and dismissed by the company.

MARKET MANIPULATION IN THE UK

In February 2016 the company was fined more than £37 million by the Competition and Markets Authority for paying Generics UK, Alpharma and Norton Healthcare more than £50m between 2001 and 2004, in order to keep generic varieties of Paroxetine
Paroxetine
out of the NHS market. The generics companies were fined a further £8 million. At the end of 2003 when generics were available in the UK the price of Paroxetine dropped 70%.

MISCELLANEOUS

Italian police sought bribery charges in May 2004 against 4,400 doctors and 273 GSK employees. GSK and its predecessor were accused of having spent £152m on physicians, pharmacists and others, giving them cameras, computers, holidays and cash. Doctors were alleged to have received cash based on the number of patients they treated with a cancer drug, topotecan (Hycamtin). The following month prosecutors in Munich accused 70–100 doctors of having accepted bribes from SmithKline Beecham between 1997 and 1999. The inquiry was opened over allegations that the company had given over 4,000 hospital doctors money and free trips. All charges were dismissed by the Verona court in January 2009.

In 2006 in the United States GSK settled the largest tax dispute in IRS history, agreeing to pay $3.1 billion. At issue were Zantac and other products sold in 1989–2005. The case revolved around intracompany transfer pricing —determining the share of profit attributable to the US subsidiaries of GSK and subject to tax by the IRS.

The UK's Serious Fraud Office (SFO) opened a criminal inquiry in 2014 into GSK's sales practices, using powers granted by the Bribery Act 2010 . The SFO said it was collaborating with Chinese authorities to investigate bringing charges in the UK related to GSK's activities in China, Europe and the Middle East. Also as of 2014 the US Department of Justice was investigating GSK with reference to the Foreign Corrupt Practices Act .

DIAGRAM OF ACQUISITION HISTORY

The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):

GLAXOSMITHKLINE

SmithKline Beecham plc (renamed 1989)

SmithKline Beckman (renamed 1982)

SmithKline-RIT (renamed 1968)

Smith, Kline padding:0;">

French, Richards and Company (Acq 1891)

Smith, Kline and Company (Founded 1830)

Lever Brothers (Angio-seal div. Acq 1900

Recherche et Industrie Thérapeutiques (Acq 1968)

Beckman Instruments, Inc. (Merged 1982, Sold 1989)

Specialized Instruments Corp. (Acq 1954)

Offner Electronics (Acq 1961)

Allergan (Acq 1982, Sold 1989)

International Clinical Laboratories (Acq 1989)

Reckitt border-left:1px solid;vertical-align:top;text-align:center;">

Stiefel Laboratories (Acq 2000 by SmithKline Beckman)

Sanofi-Synthelabo (Acq 2001)

Beecham Group Plc (merged 1989)

Norcliff Thayer (Acq 1986)

Beecham Group Ltd

S. E. Massengill Company (Acq 1971)

Beecham Group Ltd (Renamed 1945)

C.L. Bencard (Acq 1953)

County Chemicals (Acq 1929)

Glaxo Wellcome (Renamed 1995)

Glaxo (Merged 1995)

Glaxo (Founded 1850)

Joseph Nathan (Acq 1947)

Allen border-left:1px solid;vertical-align:top;text-align:center;">

Margarine Unie (Angio-seal div, Acq 1924)

Meyer Laboratories (Acq 1978)

Affymax (Acq 1995)

Burroughs Wellcome (Merged 1995)

McDougall border-left:1px solid;vertical-align:top;text-align:center;">

Burroughs Wellcome vertical-align:top;text-align:center;">

Block Drug (Acq 2001)

CNS Inc. (Acq 2006)

Stiefel Laboratories (Acq 2009)

Laboratorios Phoenix (Acq 2010)

Maxinutrition (Acq 2010)

CellZome (Acq 2011)

Human Genome Sciences (Acq 2013)

Novartis
Novartis
( Vaccine
Vaccine
div; Acq 2014)

GSK Cancer division (Sold 2014 to Novartis)

GlycoVaxyn (Acq 2015)

SEE ALSO

* Companies portal

* List of toothpaste brands * Index of oral health and dental articles * Recherche et Industrie Thérapeutiques (R.I.T.) * Galvani Bioelectronics

NOTES

* ^ Glaxo Wellcome was formed from Glaxo's 1995 acquisition of Burroughs Wellcome and SmithKline Beecham from the 1989 merger of the Beecham Group and the SmithKline Beckman Corporation . * ^ World Health Organization Expert Committee on Drug Dependence, 2003: "The Committee noted the striking number of reports on paroxetine and 'withdrawal syndrome' ... The representative of Consumers International reported that a number of patients had experienced difficulty in withdrawing from SSRIs in general. It was agreed that withdrawal was indeed a problem in some patients, but there was a difference of opinion on the degree of dependence that was involved, given the possibility that the need for treatment of resistant or relapsing disease could make these drugs indispensable for patient care. The Committee expressed concern about the possibility of inappropriate prescribing resulting in the risk of problems of withdrawal outweighing the benefits of treatment with SSRIs."

REFERENCES

* ^ _A_ _B_ _C_ "Annual Report 2016" (PDF). Retrieved 7 April 2017.

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* ^ Max Baucus , Chuck Grassley , "Finance Committee Letter to the FDA Regarding Avandia", United States Senate Finance Committee, 12 July 2010.

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* ^ "FDA requires removal of certain restrictions on the diabetes drug Avandia", Food and Drug Administration, 25 November 2013. "Readjudication of the Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycemia in Diabetes Trial (RECORD)", Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Food and Drug Administration, 5–6 June 2013. Steven Nissen, "Steven Nissen: The Hidden Agenda Behind The FDA\'s New Avandia Hearings", _Forbes_, 23 May 2013.

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" GlaxoSmithKline
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* Official website * GlaxoSmithKline
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