John Brownstein
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John Brownstein
John Brownstein is a Canadian epidemiologist and Professor of Medicine at the Harvard Medical School as well as the Chief Innovation Officer at Boston Children’s Hospital. His research focuses on development of computational methods in epidemiology for applications to public health also known as computational epidemiology or e-epidemiology He is also the founder of several global public health surveillance systems including HealthMap. He is most known for his work on global tracking of disease outbreaks. Early life and education Brownstein is the son of Veronica (Coleman) and Stephen Brownstein, and his sister is Jessica Mulroney. He is a descendant of the founders of Browns Shoes. He grew up in Montreal and obtained his bachelor's degree in biology from the McGill University in 1999. He received a Ph.D. in epidemiology in 2004 from Yale University for work on the emergence of Lyme disease and West Nile virus in the United States. Career and research Brownstein joined the fa ...
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Montreal
Montreal ( ; officially Montréal, ) is the List of the largest municipalities in Canada by population, second-most populous city in Canada and List of towns in Quebec, most populous city in the Provinces and territories of Canada, Canadian province of Quebec. Founded in 1642 as ''Fort Ville-Marie, Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple-peaked hill around which the early city of Ville-Marie is built. The city is centred on the Island of Montreal, which obtained its name from the same origin as the city, and a few much smaller peripheral islands, the largest of which is Île Bizard. The city is east of the national capital Ottawa, and southwest of the provincial capital, Quebec City. As of 2021, the city had a population of 1,762,949, and a Census Metropolitan Area#Census metropolitan areas, metropolitan population of 4,291,732, making it the List of the largest municipalities in Canada by population, second-largest city, and List of cen ...
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Jessica Mulroney
Jessica Mulroney (née Brownstein; born March 14, 1980) is a Canadian fashion stylist and marketing consultant, noted for her previous work with Kleinfeld Bridal ( Hudson's Bay), past guest appearances on television shows ''Good Morning America'' and ''CityLine'', and hosting of '' I Do, Redo''. She is a Canadian fashion advocate and contributor to Sunwing's ''Wedding Vacations'' magazine. Early life Mulroney was born Jessica Brownstein to a Jewish family, the daughter of Veronica (née Coleman) and Stephen Brownstein. Her brother is Harvard professor John Brownstein. She is a great-granddaughter of Benjamin Brownstein, the founder of Browns Shoes. She grew up in Westmount and attended Miss Edgar's and Miss Cramp's School on a scholarship. She graduated from McGill University with a degree in industrial relations. Career Early in her career, Mulroney and sibling Elizabeth distributed the lingerie lines la Perla and Cosabell. In November 2015, Mulroney styled ensembles for So ...
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Zika
Zika fever, also known as Zika virus disease or simply Zika, is an infectious disease caused by the Zika virus. Most cases have no symptoms, but when present they are usually mild and can resemble dengue fever. Symptoms may include fever, red eyes, joint pain, headache, and a maculopapular rash. Symptoms generally last less than seven days. It has not caused any reported deaths during the initial infection. Mother-to-child transmission during pregnancy can cause microcephaly and other brain malformations in some babies. Infections in adults have been linked to Guillain–Barré syndrome (GBS). Zika fever is mainly spread via the bite of mosquitoes of the ''Aedes'' type. It can also be sexually transmitted and potentially spread by blood transfusions. Infections in pregnant women can spread to the baby. Diagnosis is by testing the blood, urine, or saliva for the presence of the virus's RNA when the person is sick, or the blood for antibodies after symptoms are present more than ...
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Ebola
Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after becoming infected with the virus. The first symptoms are usually fever, sore throat, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point, some people begin to bleed both internally and externally. The disease kills between 25% and 90% of those infected – about 50% on average. Death is often due to shock from fluid loss, and typically occurs between six and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start. The virus spreads through direct contact with body fluids, such as blood from infected humans or other animals, or from contact with items that have recently been conta ...
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Cholera
Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This may result in sunken eyes, cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish. Symptoms start two hours to five days after exposure. Cholera is caused by a number of types of ''Vibrio cholerae'', with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish is a common source. Humans are the only known host for the bacteria. Risk factors for the disease include poor sanitation, not enough clea ...
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2009 Swine Flu Pandemic
The 2009 swine flu pandemic, caused by the H1N1 influenza virus and declared by the World Health Organization (WHO) from June 2009 to August 2010, is the third recent flu pandemic involving the H1N1 virus (the first being the 1918–1920 Spanish flu pandemic and the second being the 1977 Russian flu). The first two cases were discovered independently in the United States in April 2009. The virus appeared to be a new strain of H1N1 that resulted from a previous triple reassortment of bird, swine, and human flu viruses which further combined with a Eurasian pig flu virus, leading to the term "swine flu". Some studies estimated that the real number of cases including asymptomatic and mild cases could be 700 million to 1.4 billion people—or 11 to 21 percent of the global population of 6.8 billion at the time. The lower value of 700 million is more than the 500 million people estimated to have been infected by the Spanish flu pandemic. However, the Spanish flu infected approxima ...
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E-epidemiology
E-epidemiology (also known as Digital Epidemiology) is the science underlying the acquisition, maintenance and application of epidemiological knowledge and information using digital media such as the internet, mobile phones, digital paper, digital TV. E-epidemiology also refers to the large-scale epidemiological studies that are increasingly conducted through distributed global collaborations enabled by the Internet. The traditional approach in performing epidemiological trials by using paper questionnaires is both costly and time-consuming. The questionnaires have to be transformed to analyzable data and a large number of personnel are needed throughout the procedure. Modern communication tools, such as the web, cell phones and other current and future communication devices, allow rapidly and cost-efficient assembly of data on determinants for lifestyle and health for broad segments of the population. Modern IT technology provides means for storage, organization and retrieval of l ...
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Computational Epidemiology
Computational epidemiology is a multidisciplinary field that uses techniques from computer science, mathematics, geographic information science and public health to better understand issues central to epidemiology such as the spread of diseases or the effectiveness of a public health intervention. Computational epidemiology traces its origins to mathematical epidemiology, but began to experience significant growth with the rise of big data and the democratization of high-performance computing through cloud computing. Introduction In contrast with traditional epidemiology, computational epidemiology looks for patterns in unstructured sources of data, such as social media. It can be thought of as the hypothesis-generating antecedent to hypothesis-testing methods such as national surveys and randomized controlled trials. A mathematical model is developed which describes the observed behavior of the viruses, based on the available data. Then simulations of the model are performed to un ...
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Lagrange Prize
The Lagrange-CRT Foundation Prize is an annual International award created by the CRT Foundation with the scientific coordination of the ISI Foundation. The prize is awarded for scientific research in the field of complexity sciences, its applications and dissemination. The Lagrange Prize is awarded in Turin, Italy. Aim and Criteria The Lagrange-CRT Foundation Prize is awarded to a selected scientist (below 50 years of age) for achievements in research on complex systems, including theoretical and experimental research. In particular, the prize recognizes outstanding contributions relevant to the progress of complexity science. The Prize The winner of the Lagrange-CRT Foundation Prize is chosen by the Scientific Commission in collaboration with the ISI Foundation. The prize is in the amount of €50,000. The award ceremony takes place in Turin. List of Winners *2020 Corona-Researchers at the Institute for Scientific Interchange *2019 Iain Couzin , David Gruber *2018 ...
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West Nile Virus
West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the family ''Flaviviridae'', from the genus ''Flavivirus'', which also contains the Zika virus, dengue virus, and yellow fever virus. The virus is primarily transmitted by mosquitoes, mostly species of ''Culex''. The primary hosts of WNV are birds, so that the virus remains within a "bird–mosquito–bird" transmission cycle. The virus is genetically related to the Japanese encephalitis family of viruses. Humans and horses both exhibit disease symptoms from the virus, and symptoms rarely occur in other animals. Identification of the human disease was first made in 1937 in Uganda and in the latter half of the 20th century spread to many other parts of the world. Structure Like most other flaviviruses, WNV is an enveloped virus with icosahedral symmetry. Electron microscope studies reveal a 45–50 nm virion covered with a relatively smooth protein shell; this structure i ...
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Lyme Disease
Lyme disease, also known as Lyme borreliosis, is a vector-borne disease caused by the ''Borrelia'' bacterium, which is spread by ticks in the genus ''Ixodes''. The most common sign of infection is an expanding red rash, known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards. The rash is typically neither itchy nor painful. Approximately 70–80% of infected people develop a rash. Early diagnosis can be difficult. Other early symptoms may include fever, headaches and tiredness. If untreated, symptoms may include loss of the ability to move one or both sides of the face, joint pains, severe headaches with neck stiffness or heart palpitations. Months to years later repeated episodes of joint pain and swelling may occur. Occasionally shooting pains or tingling in the arms and legs may develop. Despite appropriate treatment about 10 to 20% of those affected develop joint pains, memory problems and tiredness for at least six months. Lym ...
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Yale University
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate col ...
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