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Jules Hoffman
Jules A. Hoffmann (; born 2 August 1941) is a Luxembourg-born French biologist. During his youth, growing up in Luxembourg, he developed a strong interest in insects under the influence of his father, Jos Hoffmann. This eventually resulted in the younger Hoffmann's dedication to the field of biology using insects as model organisms. He currently holds a faculty position at the University of Strasbourg. He is a research director and member of the board of administrators of the National Center of Scientific Research ( CNRS) in Strasbourg, France. He was elected to the positions of Vice-President (2005-2006) and President (2007-2008) of the French Academy of Sciences. Hoffmann and Bruce Beutler were jointly awarded a half share of the 2011 Nobel Prize in Physiology or Medicine for "their discoveries concerning the activation of innate immunity,". ore specifically, the work showing increased Drosomycin expression following activation of Toll pathway in microbial infection. Hoffmann a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Echternach
Echternach ( lb, Iechternach or (locally) ) is a commune with town status in the canton of Echternach, which is part of the district of Grevenmacher, in eastern Luxembourg. Echternach lies near the border with Germany, and is the oldest town in Luxembourg. History The town grew around the Abbey of Echternach, which was founded in 698 by St Willibrord, an English monk from Ripon, Northumbria (in present-day North Yorkshire, England), who became the first bishop of Utrecht and worked to Christianize the Frisians. As bishop, he was the Echternach monastery's abbot until his death in 739. It is in his honour that the notable Dancing procession of Echternach takes place annually on Whit Tuesday. The river Sauer that flows past the town now forms the border between Luxembourg and Germany; in the later Roman Empire and under the Merovingian dynasty, Merovingians by contrast, the Sauer did not form a border or March (territory), march in this area. The Roman villa at Echternach (traces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bruno Lemaitre
Bruno Lemaitre (born in Lille, France) is a French immunologist and a professor at the École Polytechnique Fédérale de Lausanne (EPFL). His research focuses on the mechanisms of innate immunity and endosymbiosis in Drosophila. Lemaitre has also authored several books on the topic of narcissism in science. Career Lemaitre obtained a PhD in genetics from the Université Pierre-et-Marie-Curie in 1992, defending a thesis on the regulation of P element transposition in Drosophila. He then pursued work as research associate in the laboratory of Jules Hoffmann, where he identified Toll-like receptors as essential mediators of innate immunity in Drosophila. This work was considered as a landmark paper by the Nobel prize committee and was featured in the 2011 Nobel Prize in Physiology or Medicine awarded to Hoffmann. In 1998, he was appointed group leader at the Molecular Genetics Center of the French National Center for Scientific Research in Gif-sur-Yvette. He moved to EPFL in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, five Nobel Prizes have been awarded to drosophilists for their work using the insect. ''D. melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. It was originally an African species, with all non-African lineages having a common origin. Its geographic range includes all continents, including islands. ''D. melanogaster'' is a common pest in homes, restaurants, and othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diptericin
Diptericin is a 9 kDa antimicrobial peptide (AMP) of flies first isolated from the blowfly ''Phormia terranova''. It is primarily active against Gram-negative bacteria, disrupting bacterial membrane integrity. The structure of this protein includes a proline-rich domain with similarities to the AMPs drosocin, pyrrhocoricin, and abaecin, and a glycine-rich domain with similarity to attacin. Diptericin is an iconic readout of immune system activity in flies, used ubiquitously in studies of ''Drosophila'' immunity. Diptericin is named after the insect order Diptera. Structure and function Diptericins are found throughout Diptera, but are most extensively characterized in ''Drosophila'' fruit flies. The mature structures of diptericins are unknown, though previous efforts to synthesize Diptericin have suggested Diptericin in ''Protophormia terraenovae'' is one linear peptide. Yet ''Drosophila melanogaster's'' Diptericin B peptide is likely cleaved into two separate peptides. Synt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phormia Terranovae
''Phormia regina'', the black blow fly, belongs to the blow fly family Calliphoridae and was first described by Johann Wilhelm Meigen. The black blow fly's wings are specialized with a sharp bend. These flies are also have well-developed calypters. Blow flies generally are about the size of a house fly or a little larger, and many are metallic blue or green in color. Key characteristics of this species include black gena, mostly white calypters, and anterior thoracic spiracles that appear to be orange yellow due to being surrounded by bright orange setae. ''P. regina'' is especially important to forensic entomology. Female ''P. regina'', like other blow flies in the family Calliphoridae, oviposit their eggs on carrion, where they hatch. The larvae develop through three instar stages until pupation. Adult black blow flies aggregate on feces in order to mate. The success of these mating interactions has been studied appears related to size and diet of the adult flies. Following s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacillus Thuringiensis
''Bacillus thuringiensis'' (or Bt) is a gram-positive, soil-dwelling bacterium, the most commonly used biological pesticide worldwide. ''B. thuringiensis'' also occurs naturally in the gut of caterpillars of various types of moths and butterflies, as well on leaf surfaces, aquatic environments, animal feces, insect-rich environments, and flour mills and grain-storage facilities. It has also been observed to parasitize other moths such as ''Cadra calidella''—in laboratory experiments working with ''C. calidella'', many of the moths were diseased due to this parasite. During sporulation, many Bt strains produce crystal proteins (proteinaceous inclusions), called delta endotoxins, that have insecticidal action. This has led to their use as insecticides, and more recently to genetically modified crops using Bt genes, such as Bt corn. Many crystal-producing Bt strains, though, do not have insecticidal properties. The subspecies ''israelensis'' is commonly used for control of mosq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Metchnikoff
Eli most commonly refers to: * Eli (name), a given name, nickname and surname * Eli (biblical figure) Eli or ELI may also refer to: Film * ''Eli'' (2015 film), a Tamil film * ''Eli'' (2019 film), an American horror film Music * ''Eli'' (Jan Akkerman album) (1976) * ''Eli'' (Supernaut album) (2006) Places * Alni, Ardabil Province, Iran, also known as Elī * Eli, Mateh Binyamin, an Israeli settlement in the West Bank * Éile or Éli, a medieval kingdom in Ireland * Eli, Kentucky, United States * Eli, Nebraska, United States * Eli, West Virginia, United States Other uses * ''Eli'' (opera), an opera by Walter Steffens * ELI (programming language) * Earth Learning Idea * English language institute * Environmental Law Institute, an American environmental law policy organization * European Law Institute * European Legislation Identifier * Extreme Light Infrastructure, a proposed high energy laser research facility of the European Union * Eli, someone from Yale University, after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marburg An Der Lahn
Marburg ( or ) is a university town in the German federal state (''Bundesland'') of Hesse, capital of the Marburg-Biedenkopf district (''Landkreis''). The town area spreads along the valley of the river Lahn and has a population of approximately 76,000. Having been awarded town privileges in 1222, Marburg served as capital of the landgraviate of Hessen-Marburg during periods of the fifteenth to seventeenth centuries. The University of Marburg was founded in 1527 and dominates the public life in the town to this day. Marburg is a historic centre of the pharmaceutical industry in Germany, and there is a plant in the town (by BioNTech) to produce vaccines to tackle Covid-19. History Founding and early history Like many settlements, Marburg developed at the crossroads of two important early medieval highways: the trade route linking Cologne and Prague and the trade route from the North Sea to the Alps and on to Italy, the former crossing the river Lahn here. A first mention ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philipps-Universität Marburg
The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the world. It is now a public university of the state of Hesse, without religious affiliation. The University of Marburg has about 23,500 students and 7,500 employees and is located in Marburg, a town of 76,000 inhabitants, with university buildings dotted in or around the town centre. About 14 per cent of the students are international, the highest percentage in Hesse. It offers an International summer university programme and offers student exchanges through the Erasmus programme. History In 1609, the University of Marburg established the world's first professorship in chemistry. In 2012 it opened the first German interactive chemistry museum, called '. Its experimental course programme is aimed at encouraging young people to pursue careers in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lycée De Garçons De Luxembourg
The Lycée de Garçons de Luxembourg ( en, Luxembourg Boys' High School) is a high school in Luxembourg City, in southern Luxembourg. The Lycée is located in the Limpertsberg quarter, in the north-west of the city and is currently considered to be among the top secondary institutions in Luxembourg. Today, it is a mixed school, girls are allowed since the 60s. The origins of the Lycée de Garçons go back to the first half of the 19th century, when Luxembourg saw the birth of industry and financial institutions alongside archaic agriculture and craftsmanship. The Athénée de Luxembourg's main mission being to train the country's intellectual elite on the basis of an education that was above all humanistic, there was an obvious need to give life to a school that could train engineers and accountants. Thus, the law of July 23, 1848 on higher and middle education created within the Athénée "an industrial school open to young people destined for the arts, industry and commerce". Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Septic Shock
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defines septic shock as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Patients with septic shock can be clinically identified by requiring a vasopressor to maintain a mean arterial pressure of 65 mm Hg or greater and having serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. This combination is associated with hospital mortality rates greater than 40%. The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. It may be located in any part of the body, but mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
