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Josef Issels
Josef M. Issels (November 21, 1907 – February 11, 1998) was a German physician known for promoting an alternative cancer therapy regimen, the Issels treatment. He claimed to cure cancer patients who had been declared incurable by conventional cancer treatments. During Issels' lifetime, his methods were controversial, and in 1961 he was charged with fraud and manslaughter for allegedly promising fraudulent cancer cures and for the subsequent deaths of patients under his care who refused standard cancer treatment. An initial conviction on the manslaughter charge was overturned in 1964 on the grounds that Issels had genuinely believed that his therapy could cure cancer.German Doctor Acquitted
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Mönchengladbach
Mönchengladbach (, li, Jlabbach ) is a city in North Rhine-Westphalia, Germany. It is located west of the Rhine, halfway between Düsseldorf and the Dutch border. Geography Municipal subdivisions Since 2009, the territory of Mönchengladbach has comprised four (previously ten) boroughs which are subdivided into 44 districts. The boroughs and their associated districts * ''Nord:'' Am Wasserturm, Dahl, Eicken, Gladbach, Hardt-Mitte, Hardter Wald, Ohler, Venn, Waldhausen, Westend, Windberg * ''Ost:'' Bettrath‑Hoven, Bungt, Flughafen, Giesenkirchen‑Mitte, Giesenkirchen‑Nord, Hardterbroich‑Pesch, Lürrip, Neuwerk‑Mitte, Schelsen, Uedding * ''Süd:'' Bonnenbroich‑Geneicken, Geistenbeck, Grenzland‑Stadion, Heyden, Hockstein, Mülfort, Odenkirchen‑Mitte, Odenkirchen‑West, Pongs, Rheydt, Sasserath, Schloss Rheydt, Schmölderpark, Schrievers * ''West:'' Hauptquartier, Hehn, Holt, Rheindahlen‑Land, Rheindahlen‑Mi ...
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Wehrmacht
The ''Wehrmacht'' (, ) were the unified armed forces of Nazi Germany from 1935 to 1945. It consisted of the ''Heer'' (army), the ''Kriegsmarine'' (navy) and the ''Luftwaffe'' (air force). The designation "''Wehrmacht''" replaced the previously used term and was the manifestation of the Nazi regime's efforts to rearm Germany to a greater extent than the Treaty of Versailles permitted. After the Nazi rise to power in 1933, one of Adolf Hitler's most overt and audacious moves was to establish the ''Wehrmacht'', a modern offensively-capable armed force, fulfilling the Nazi régime's long-term goals of regaining lost territory as well as gaining new territory and dominating its neighbours. This required the reinstatement of conscription and massive investment and defense spending on the arms industry. The ''Wehrmacht'' formed the heart of Germany's politico-military power. In the early part of the Second World War, the ''Wehrmacht'' employed combined arms tactics (close-cover ...
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Lillian Board
Lillian Barbara Board, (13 December 1948 – 26 December 1970) was a British athlete. She won the silver medal in the 400 metres at the 1968 Summer Olympics in Mexico City, and two gold medals at the 1969 European Championships in Athletics in Athens. Her career was cut short in 1970 when she developed the colorectal cancer that within months would claim her life. Early life Board was born in Durban on 13 December 1948. Her parents, George and Frances Board, had emigrated from Manchester, England, to South Africa in April 1947, along with their son George Alfred. Growing homesick shortly after the birth of Lillian and her fraternal twin sister, Irene, the family moved back to Manchester in February 1950. In 1956, the family moved to Ealing, west London, where Lillian and Irene, then aged 7, started studying at Drayton Green School. Developing athletics career In 1960, at the age of 11, Lillian and her sister moved to Grange Secondary Modern Girls' School, also in Ealing and ...
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Bob Marley
Robert Nesta Marley (6 February 1945 – 11 May 1981; baptised in 1980 as Berhane Selassie) was a Jamaican singer, musician, and songwriter. Considered one of the pioneers of reggae, his musical career was marked by fusing elements of reggae, ska, and rocksteady, as well as his distinctive vocal and songwriting style. Marley's contributions to music increased the visibility of Jamaican music worldwide, and made him a global figure in popular culture to this day. Over the course of his career, Marley became known as a Rastafari icon, and he infused his music with a sense of spirituality. He is also considered a global symbol of Jamaican music and culture and identity, and was controversial in his outspoken support for democratic social reforms. In 1976, Marley survived an assassination attempt in his home, which was thought to be politically motivated. He also supported legalization of marijuana, and advocated for Pan-Africanism. Born in Nine Mile, Jamaica, Ma ...
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Bavaria
Bavaria ( ; ), officially the Free State of Bavaria (german: Freistaat Bayern, link=no ), is a state in the south-east of Germany. With an area of , Bavaria is the largest German state by land area, comprising roughly a fifth of the total land area of Germany. With over 13 million inhabitants, it is second in population only to North Rhine-Westphalia, but due to its large size its population density is below the German average. Bavaria's main cities are Munich (its capital and largest city and also the third largest city in Germany), Nuremberg, and Augsburg. The history of Bavaria includes its earliest settlement by Iron Age Celtic tribes, followed by the conquests of the Roman Empire in the 1st century BC, when the territory was incorporated into the provinces of Raetia and Noricum. It became the Duchy of Bavaria (a stem duchy) in the 6th century AD following the collapse of the Western Roman Empire. It was later incorporated into the Holy Roman Empire, became an ind ...
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Manfred Von Ardenne
Manfred von Ardenne (20 January 1907 – 26 May 1997) was a German researcher and applied physicist and inventor. He took out approximately 600 patents in fields including electron microscopy, medical technology, nuclear technology, plasma physics, and radio and television technology. From 1928 to 1945, he directed his private research laboratory ''Forschungslaboratorium für Elektronenphysik''. For ten years after World War II, he worked in the Soviet Union on their atomic bomb project and was awarded a Stalin Prize. Upon his return to the then East Germany, he started another private laboratory, ''Forschungsinstitut Manfred von Ardenne''. Career Early years The stormy life of von Ardenne's grandmother, Elisabeth von Ardenne (1853–1952), is said to have been be the inspiration for ''Effi Briest'' by Theodor Fontane, one of the most famous German realist novels. Born in 1907 in Hamburg to a wealthy aristocratic family, Ardenne was the oldest of five children. In 1913, Ard ...
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Hyperthermia
Hyperthermia, also known simply as overheating, is a condition in which an individual's body temperature is elevated beyond normal due to failed thermoregulation. The person's body produces or absorbs more heat than it dissipates. When extreme temperature elevation occurs, it becomes a medical emergency requiring immediate treatment to prevent disability or death. Almost half a million deaths are recorded every year from hyperthermia. The most common causes include heat stroke and adverse reactions to drugs. Heat stroke is an body temperature, acute temperature elevation caused by exposure to excessive heat, or combination of heat and humidity, that overwhelms the heat-regulating mechanisms of the body. The latter is a relatively rare side effect of many drugs, particularly those that affect the central nervous system. Malignant hyperthermia is a rare complication of some types of general anesthesia. Hyperthermia can also be caused by a traumatic brain injury. Hyperthermia di ...
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William Coley
William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher best known for his early contributions to the study of cancer immunotherapy. Although his work was not proven effective in his lifetime, modern discoveries and research in immunology have led to a greater appreciation for his work in cancer immunotherapy and his targeted therapy, Coley's toxins. Today, Coley is recognized as the ''Father of Cancer Immunotherapy'' for his contributions to the science. Early life and career Education William Coley was born on January 12, 1862, in Saugatuck, a neighborhood of Westport, Connecticut. His parents were Horace Bradley Coley and Clarina B. Wakeman. He received his bachelor's degree in Classics from Yale University and his medical degree from Harvard Medical School in 1888. After his schooling, Coley began working at New York Hospital, now Weill Cornell Medical Center, as a surgical intern. Early sarcoma patients In 1890, Coley b ...
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Coley Vaccine
Coley's toxins (also called Coley's toxin, Coley's vaccine, Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture containing toxins filtered from killed bacteria of species ''Streptococcus pyogenes'' and ''Serratia marcescens'', named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment for cancer. Their use in the late nineteenth and early 20th centuries represented a precursor to modern immunotherapy, although at that time their mechanism of action was not completely understood. Many important aspects of the mechanisms of action, such as that involving T-cells and NK cells, have been more recently identified. The FDA-approved BCG for non-muscle invasive bladder cancer is a highly related strategy of Coley's Toxin. History Bacterial immunotherapy for the treatment of cancer has been utilized throughout history, with the earliest cases going back to c 2600 BC. Egyptian ...
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms ( palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). The development of therapies with specific molecular or genetic targets, wh ...
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Surgery
Surgery ''cheirourgikē'' (composed of χείρ, "hand", and ἔργον, "work"), via la, chirurgiae, meaning "hand work". is a medical specialty that uses operative manual and instrumental techniques on a person to investigate or treat a pathological condition such as a disease or injury, to help improve bodily function, appearance, or to repair unwanted ruptured areas. The act of performing surgery may be called a surgical procedure, operation, or simply "surgery". In this context, the verb "operate" means to perform surgery. The adjective surgical means pertaining to surgery; e.g. surgical instruments or surgical nurse. The person or subject on which the surgery is performed can be a person or an animal. A surgeon is a person who practices surgery and a surgeon's assistant is a person who practices surgical assistance. A surgical team is made up of the surgeon, the surgeon's assistant, an anaesthetist, a circulating nurse and a surgical technologist. Surgery usually spa ...
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Immune System
The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use molecules and cells to perform their functions. Nearly all organisms have some kind of immune system. Bacteria have a rudimentary immune system in the form of enzymes that protect against virus infections. Other basic immune mechanisms evolved in ancient plants and animals and remain in their modern descendants. These mechanisms include phagocytosis, antimicrobial pe ...
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