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John Q. Trojanowski
John Quinn Trojanowski (December 17, 1946 – February 8, 2022) was an American academic research neuroscientist specializing in neurodegeneration. He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration. Biography John Quinn Trojanowski was born on December 17, 1946, in Bridgeport, Connecticut, as the second of the seven children of Maurice Trojanowski and Margaret (Quinn) Trojanowski. Trojanowski obtained his M.D./Ph.D. in 1976 from Tufts University in Boston. After a medicine internship at Mt. Auburn Hospital and Harvard Medical School, he began pathology/neuropathology training at Massachusetts General Hospital and Harvard Medical School (1977–1979), and completed training at the University of Pennsylvania School of Medicine in 1980 where he was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodegeneration
A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frontotemporal Lobar Degeneration
Frontotemporal lobar degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes. Common proteinopathies that are found in FTLD include the accumulation of tau proteins and TAR DNA-binding protein 43 (TDP-43). Mutations in the ''C9orf72'' gene have been established as a major genetic contribution of FTLD, although defects in the granulin (GRN) and microtubule-associated proteins (MAPs) are also associated with it. Classification There are 3 main histological subtypes found at post-mortem: * FTLD-tau is characterised by tau positive inclusion bodies often referred to as Pick-bodies. Examples of FTLD-tau include; Pick's disease, corticobasal degeneration, progressive supranuclear palsy. * FTLD-TDP (or FTLD-U ) is characterised by ubiquitin and TDP-43 positive, tau negative, FUS negative inclusion bodies. The pathological h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School Alumni
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease Researchers
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of APOE. Other risk factors include a history of head injury, clinical depression, and high blood press ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tufts University School Of Medicine Alumni
Tufts University is a private research university on the border of Medford and Somerville, Massachusetts. It was founded in 1852 as Tufts College by Christian universalists who sought to provide a nonsectarian institution of higher learning. Tufts remained a small New England liberal arts college until the 1970s, when it transformed into a large research university offering several doctorates;Its corporate name is still "The Trustees of Tufts College" it is classified as a "Research I university", denoting the highest level of research activity. Tufts is a member of the Association of American Universities, a selective group of 64 leading research universities in North America. The university is known for its internationalism, study abroad programs, and promoting active citizenship and public service across all disciplines. Tufts offers over 90 undergraduate and 160 graduate programs across ten schools in the greater Boston area and Talloires, France. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2022 Deaths
The following notable deaths occurred in 2022. Names are reported under the date of death, in alphabetical order. A typical entry reports information in the following sequence: * Name, age, country of citizenship at birth, subsequent nationality (if applicable), what subject was noted for, cause of death (if known), and reference. December 25 * Chalapathi Rao, 78, Indian actor and producer, heart attack. (death announced on this date) 24 *Vittorio Adorni, 85, Italian road racing cyclist. *Cotton Davidson, 91, American football player ( Baltimore Colts, Dallas Texans, Oakland Raiders). (death announced on this date) *Franco Frattini, 65, Italian politician and magistrate, twice minister of foreign affairs, twice of public administration, European commissioner for justice (2004–2008), cancer. *Madosini, 78, South African musician. *Barry Round, 72, Australian footballer (Sydney, Footscray, Williamstown), organ failure. *Royal Applause, 29, British Thoroughbred racehorse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1946 Births
Events January * January 6 - The 1946 North Vietnamese parliamentary election, first general election ever in Vietnam is held. * January 7 – The Allies recognize the Austrian republic with its 1937 borders, and divide the country into four Allied-occupied Austria, occupation zones. * January 10 ** The first meeting of the United Nations is held, at Methodist Central Hall Westminster in London. ** ''Project Diana'' bounces radar waves off the Moon, measuring the exact distance between the Earth and the Moon, and proves that communication is possible between Earth and outer space, effectively opening the Space Age. * January 11 - Enver Hoxha declares the People's Republic of Albania, with himself as prime minister of Albania, prime minister. * January 16 – Charles de Gaulle resigns as head of the Provisional Government of the French Republic, French provisional government. * January 17 - The United Nations Security Council holds its first session, at Church House, Westmin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eugene Garfield
Eugene Eli Garfield (September 16, 1925 – February 26, 2017) was an American linguist and businessman, one of the founders of bibliometrics and scientometrics. He helped to create ''Current Contents'', ''Science Citation Index'' (SCI), ''Journal Citation Reports'', and ''Index Chemicus'', among others, and founded the magazine '' The Scientist''. Early life and education Garfield was born in 1925 in New York City as Eugene Eli Garfinkle, his mother being of Lithuanian Jewish ancestry. His parents were second generation immigrants living in East Bronx in New York City. He studied at the University of Colorado and University of California, Berkeley before getting a Bachelor of Science degree in chemistry from Columbia University in 1949. Garfield also received a degree in Library Science from Columbia University in 1953 He went on to do his PhD in the Department of Linguistics at the University of Pennsylvania, which he completed in 1961 for developing an algorithm for translatin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Scott Award
John Scott Award, created in 1816 as the John Scott Legacy Medal and Premium, is presented to men and women whose inventions improved the "comfort, welfare, and happiness of human kind" in a significant way. "...the John Scott Medal Fund, established in 1816...". Since 1919 the Board of Directors of City Trusts of Philadelphia provide this award, recommended by an advisory committee. Eugene Garfield is member of the Advisory Committee. In 1822 the first awards were given to thirteen people by the Philadelphia Society for Promoting Agriculture entrusted by the "Philadelphia City Council, Corporation of the city of Philadelphia". The druggist John Scott of Edinburgh organized a $4,000 fund which, after his death in 1815 was administered by a merchant until the first award, a copper medal and "an amount not to exceed twenty dollars", was given in 1822. (At the time, $20 could buy one ox or a 12-volume encyclopedia.) Several hundred recipients have since been selected by the Philadelph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metlife Foundation Award For Medical Research In Alzheimer's Disease
The Metlife Foundation Award for Medical Research in Alzheimer's Disease were awarded annually from 1986 to 2016 to recognize scientific contributions toward a better understanding of the underlying causes, prevention, and treatments of Alzheimer's disease. The awards were endowed by the Metlife Foundation and administered by The American Federation for Aging Research. Each of the winners received a personal award of US$50,000 and US$200,000 in research funds to further their research. Recipients Source: See also * List of medicine awards * List of neuroscience awards This list of biology awards is an index to articles about notable awards for biology. It includes a general list and lists of ecology, genetics and neuroscience awards. It excludes awards for biochemistry, biomedical science, medicine, ornithol ... References {{DEFAULTSORT:Metlife Foundation Award Medicine awards Neuroscience awards Awards established in 1988 American science and technology awards< ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain & Behavior Research Foundation
The Brain & Behavior Research Foundation (BBRF) is a nonprofit 501(c)(3) organization that funds mental health Mental health encompasses emotional, psychological, and social well-being, influencing cognition, perception, and behavior. It likewise determines how an individual handles stress, interpersonal relationships, and decision-making. Mental health ... research. It was originally called the National Alliance for Research on Schizophrenia & Depression or the acronym for that, NARSAD. It received its nonprofit ruling in 1981. BBRF states that it is "committed to alleviating the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research." The Foundation focuses its research grants in the following areas: addiction, ADHD, anxiety, autism, bipolar disorder, borderline personality disorder, depression, eating disorders, OCD, PTSD, schizophrenia, as well as research in suicide prevention. Grant applications (943 i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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