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John J. Abel
John Jacob Abel (19 May 1857 – 26 May 1938) was an American biochemist and pharmacologist. He established the pharmacology department at Johns Hopkins University School of Medicine in 1893, and then became America's first full-time professor of pharmacology. During his time at Hopkins, he made several important medical advancements, especially in the field of hormone extraction. In addition to his laboratory work, he founded several significant scientific journals such as the ''Journal of Biological Chemistry'' and the ''Journal of Pharmacology and Experimental Therapeutics''. Early life and education John Jacob Abel was born in 1857 to George M. and Mary (Becker) Abel near Cleveland, Ohio. He earned his Ph.B. (Bachelor of Philosophy) from the University of Michigan where he studied under Henry Sewall in 1883. But, during this time he took several years off to serve as a principal of the high school in La Porte, Indiana. There he taught many subjects ranging from chemistry and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland
Cleveland ( ), officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in the northeastern part of the state, it is situated along the southern shore of Lake Erie, across the U.S. maritime border with Canada, northeast of Cincinnati, northeast of Columbus, and approximately west of Pennsylvania. The largest city on Lake Erie and one of the major cities of the Great Lakes region, Cleveland ranks as the 54th-largest city in the U.S. with a 2020 population of 372,624. The city anchors both the Greater Cleveland metropolitan statistical area (MSA) and the larger Cleveland–Akron–Canton combined statistical area (CSA). The CSA is the most populous in Ohio and the 17th largest in the country, with a population of 3.63 million in 2020, while the MSA ranks as 34th largest at 2.09 million. Cleveland was founded in 1796 near the mouth of the Cuyahoga River by General Moses Cleaveland, after whom the city was named ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kidney Dialysis
Kidney dialysis (from Greek , , 'dissolution'; from , , 'through', and , , 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally. This is referred to as renal replacement therapy. The first successful dialysis was performed in 1943. Dialysis may need to be initiated when there is a sudden rapid loss of kidney function, known as acute kidney injury (previously called acute renal failure), or when a gradual decline in kidney function, chronic kidney disease, reaches stage 5. Stage 5 chronic renal failure is reached when the glomerular filtration rate is 10–15% of normal, creatinine clearance is less than 10 mL per minute and uremia is present. Dialysis is used as a temporary measure in either acute kidney injury or in those awaiting kidney transplant and as a permanent measure in those for whom a transplant is not indicated or not possible.Pendse S, Singh A, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha amino acids appear in the genetic code. Amino acids can be classified according to the locations of the core structural functional groups, as Alpha and beta carbon, alpha- , beta- , gamma- or delta- amino acids; other categories relate to Chemical polarity, polarity, ionization, and side chain group type (aliphatic, Open-chain compound, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acid '' residues'' form the second-largest component (water being the largest) of human muscles and other tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis. It is thought that they played a key role in enabling life ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Rowntree
Leonard George Rowntree (1883–1959) was a Canadian physician and medical researcher who was credited with founding the research tradition at the Mayo Clinic. He is most well known for pioneering kidney research including the Rowntree test for kidney function; dialysis; the intravenous pyelogram and plasmapheresis. Rowntree was awarded the Medal for Merit in 1946. Early life Rowntree was born in London, Ontario, on April 10, 1883. He entered University of Western Ontario medical school in 1901, graduating in 1905 with the gold medal. He interned at Victoria Hospital and then entered general practice in Camden, New Jersey. A year later he attended a lecture given by William Osler in Philadelphia. He approached Osler about his career. Academic career Osler recommended Rowntree to Johns Hopkins Hospital where he worked with John J. Abel, a prominent pharmacologist. Abel introduced him to phthalein, from which he and J. T. Geraghty developed the Rowntree test of renal function. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenal Medulla
The adrenal medulla ( la, medulla glandulae suprarenalis) is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland, consisting of chromaffin cells that secrete catecholamines, including epinephrine (adrenaline), norepinephrine (noradrenaline), and a small amount of dopamine, in response to stimulation by sympathetic preganglionic neurons. Structure The adrenal medulla consists of irregularly shaped cells grouped around blood vessels. These cells are intimately connected with the sympathetic division of the autonomic nervous system (ANS). These adrenal medullary cells are modified postganglionic neurons, and preganglionic autonomic nerve fibers lead to them directly from the central nervous system. The adrenal medulla affects energy availability, heart rate, and basal metabolic rate. Recent research indicates that the adrenal medulla may receive input from higher-order cognitive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epinephrine
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node, pupil dilation response, and blood sugar level. It does this by binding to alpha and beta receptors. It is found in many animals, including humans, and some single-celled organisms. It has also been isolated from the plant ''Scoparia dulcis'' found in Northern Vietnam. Medical uses As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled adrenaline may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Robertson Cushny
Arthur Robertson Cushny FRS FRSE LLD (6 March 1866 – 25 February 1926), was a Scottish pharmacologist and physiologist who became a Fellow of the Royal Society. Life Cushny was born on 6 March 1866 in Fochabers, Moray, Scotland, the fourth son of Rev John Cushny of Speymouth and his wife, Catherine Ogilvie Brown. He attended a local rural school until he enrolled at the University of Aberdeen and received an M.A. in 1886. Then in 1889 he graduated from medical studies at Marischal College, Aberdeen, receiving C.M., M.B. and M.D. degrees in 1892. Aroused by interests of physiological drug interaction, he traveled to the European continent and spent a year of associated study under Oswald Schmiedeberg at Straßburg, German Empire and six months in Berne under Hugo Kronecker, from whom he learned elements of physiological technique. Then in 1893, at age 27, he accepted the chairmanship of pharmacology at the University of Michigan, replacing the newly resigned Professor J. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oswald Schmiedeberg
Johann Ernst Oswald Schmiedeberg (10 October 1838 – 12 July 1921) was a Baltic German pharmacologist. In 1866 he earned his medical doctorate from the University of Dorpat with a thesis concerning the measurement of chloroform in blood, before becoming the first professor of pharmacology at the University of Strasbourg, where he remained for 46 years. In 1911, he testified in the ''United States v. Forty Barrels and Twenty Kegs of Coca-Cola'' trial, and later, was a major factor in the success of the German pharmaceutical industry prior to the Second World War, having trained most of the European professors at the time. Early life and family Oswald Schmiedeberg was born in Courland, one of the Baltic provinces of Russia. His father Wilhelm Ludwig (1809–1878) was a bailiff in Leidzen and later forester in Paggar (Estonia). His mother Anna Lucie Bernard (1813–1871) was the daughter of a watchmaker from Lausanne. Oswald was the eldest of six siblings of whom a brother Johann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Friedrich Daniel Von Recklinghausen
Friedrich Daniel von Recklinghausen (; December 2, 1833 – August 26, 1910) was a German pathologist born in Gütersloh, Westphalia. He was the father of physiologist Heinrich von Recklinghausen (1867–1942). Early life Recklinghausen was born in Gütersloh, Germany, in 1833. He was the son of Friedrich Christoph von Recklinghausen and Friederike Charlotte Zumwinkel. His father was an elementary school teacher and a sexton. His mother died shortly after his birth in 1833. The Recklinghausens were a patrician family who put multiple councilors and mayors in their positions. He went to the elementary school where his father taught in Gütersloh. He then attended high school at Ratsgymnasium, Bielefeld. Academic background Starting in 1852, Recklinghausen studied medicine at the Universities of Bonn, Würzburg, and Berlin, earning his doctorate at the latter institution in 1855. Afterwards he studied pathological anatomy under Rudolf Virchow, the father of modern pathology, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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