John David Spillane
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John David Spillane
John David "Jerry" Spillane (1909–1985) was a Welsh neurologist and a pioneer of tropical neurology. Biography After education at Howardian High School and then graduation BSc from University College Cardiff, Spillane studied medicine at Cardiff's Welsh National School of Medicine, graduating there MB BCh (Wales) in 1933. He qualified MRCP in 1936. In 1937 he went to the USA as a Commonwealth Fund fellow, studying under Paul Dudley White at Harvard Medical School and Massachusetts General Hospital. In 1938 Spillane was awarded a Harvard research fellowship and studied at the Neurological Institute of New York affiliated with Columbia University College of Physicians and Surgeons. In 1939 he returned to the UK and graduated MD (Wales) with a thesis based on his research in cardiology. In 1939 in East Glamorgan, Glamorganshire, he married Joan Rees, daughter of a Cardiganshire physician. Spillane then enlisted in the RAMC and was posted to the military hospital at Aldershot. ...
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Cardiff
Cardiff (; cy, Caerdydd ) is the capital and largest city of Wales. It forms a principal area, officially known as the City and County of Cardiff ( cy, Dinas a Sir Caerdydd, links=no), and the city is the eleventh-largest in the United Kingdom. Located in the south-east of Wales and in the Cardiff Capital Region, Cardiff is the county town of the historic county of Glamorgan and in 1974–1996 of South Glamorgan. It belongs to the Eurocities network of the largest European cities. A small town until the early 19th century, its prominence as a port for coal when mining began in the region helped its expansion. In 1905, it was ranked as a city and in 1955 proclaimed capital of Wales. Cardiff Built-up Area covers a larger area outside the county boundary, including the towns of Dinas Powys and Penarth. Cardiff is the main commercial centre of Wales as well as the base for the Senedd. At the 2021 census, the unitary authority area population was put at 362,400. The popula ...
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Cambridge Military Hospital
Cambridge Military Hospital was a hospital completed in 1879 in Aldershot Garrison, Hampshire, England which served the various British Army camps there. During World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ..., the Cambridge Hospital was the first base hospital to receive casualties directly from the Western Front (World War I), Western Front. It was also the first place where plastic surgery was performed in the British Empire under Harold Gillies. It is now the residential estate Gun Hill Park. Earlier hospitals in Aldershot The first British Military Hospital, military hospital in Aldershot was a wooden hutted structure, near the Garrison Church (building), Church established for lunatics and infectious diseases as well as providing some family accommodation. Se ...
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Subacute Myelo-optic Neuropathy
Subacute myelo-optic neuropathy (SMON) is an iatrogenic disease of the nervous system leading to a disabling paralysis, blindness and even death. Its defining manifestation was as an epidemic in Japan during the 1960s: the Japanese government estimated 11,000 were affected; however, the College of Medicine at the University of Tokyo put the number at 30,000, citing a lack of preservation of medical records for longer than five years and a lack of cooperation from doctors as the reasons for the discrepancy. On August 3, 1978, the Tokyo District Court ruled that the cause of SMON is Clioquinol. Its manufacturer, Ciba-Geigy, has publicly stated that "Medical products manufactured and sold by us have been responsible for the occurrence of MONin Japan, we extend our apologies." SMON was first observed and diagnosed in Sweden 1966, by the pediatrician and neurologist Olle Hansson.Hansson, Olle: Inside Ciba-Geigy, 1989 Clioquinol was marketed as a prophylaxis to tourist diarrhoea. Dr. Olle ...
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Diabetes Insipidus
Diabetes insipidus (DI), recently renamed to Arginine Vasopressin Deficiency (AVP-D) and Arginine Vasopressin Resistance (AVP-R), is a condition characterized by large amounts of dilute urine and increased thirst. The amount of urine produced can be nearly 20 liters per day. Reduction of fluid has little effect on the concentration of the urine. Complications may include dehydration or seizures. There are four types of DI, each with a different set of causes. Central DI (CDI) is due to a lack of the hormone vasopressin (antidiuretic hormone). This can be due to injury to the hypothalamus or pituitary gland or genetics. Nephrogenic DI (NDI) occurs when the kidneys do not respond properly to vasopressin. Dipsogenic DI is a result of excessive fluid intake due to damage to the hypothalamic thirst mechanism. It occurs more often in those with certain psychiatric disorders or on certain medications. Gestational DI occurs only during pregnancy. Diagnosis is often based on urine ...
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Restless Legs Syndrome
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is generally a long-term disorder that causes a strong urge to move one's legs. There is often an unpleasant feeling in the legs that improves somewhat by moving them. This is often described as aching, tingling, or crawling in nature. Occasionally, arms may also be affected. The feelings generally happen when at rest and therefore can make it hard to sleep. Due to the disturbance in sleep, people with RLS may have daytime sleepiness, low energy, irritability and a depressed mood. Additionally, many have limb twitching during sleep. RLS is not the same as habitual foot tapping or leg rocking. Risk factors for RLS include low iron levels, kidney failure, Parkinson's disease, diabetes mellitus, rheumatoid arthritis, pregnancy and celiac disease. A number of medications may also trigger the disorder including antidepressants, antipsychotics, antihistamines, and calcium channel blockers. There are two main ty ...
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Iatrogenesis
Iatrogenesis is the causation of a disease, a harmful complication, or other ill effect by any medical activity, including diagnosis, intervention, error, or negligence. "Iatrogenic", ''Merriam-Webster.com'', Merriam-Webster, Inc., accessed 27 Jun 2020. First used in this sense in 1924, the term was introduced to sociology in 1976 by Ivan Illich, alleging that industrialized societies impair quality of life by overmedicalizing life."iatrogenesis"
''A Dictionary of Sociology'', . updated 31 May 2020.
Iatrogenesis may thus include mental suffering via medical beliefs or a practitioner's statements. Some iatrogenic ...
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Septum Pellucidum
The septum pellucidum (Latin for "translucent wall") is a thin, triangular, vertical double membrane separating the anterior horns of the left and right lateral ventricles of the brain. It runs as a sheet from the corpus callosum down to the fornix. The septum is not present in the syndrome septo-optic dysplasia. Structure The septum pellucidum is located in the septal area in the midline of the brain between the two cerebral hemispheres. The septal area is also the location of the septal nuclei. It is attached to the lower part of the corpus callosum, the large collection of nerve fibers that connect the two cerebral hemispheres. It is attached to the front forward part of the fornix. The lateral ventricles sit on either side of the septum. The septum pellucidum consists of two layers or ''laminae'' of both white and gray matter. During fetal development, there is a space between the two laminae called the cave of septum pellucidum that, in ninety percent of cases, disappear ...
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Boxing
Boxing (also known as "Western boxing" or "pugilism") is a combat sport in which two people, usually wearing protective gloves and other protective equipment such as hand wraps and mouthguards, throw punches at each other for a predetermined amount of time in a boxing ring. Although the term "boxing" is commonly attributed to "western boxing", in which only the fists are involved, boxing has developed in various ways in different geographical areas and cultures. In global terms, boxing is a set of combat sports focused on striking, in which two opponents face each other in a fight using at least their fists, and possibly involving other actions such as kicks, elbow strikes, Knee (strike), knee strikes, and headbutts, depending on the rules. Some of the forms of the modern sport are western boxing, Bare-knuckle boxing, bare knuckle boxing, kickboxing, Muay Thai, muay-thai, lethwei, savate, and Sanda (sport), sanda. Boxing techniques have been incorporated into many martial ar ...
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Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repeated trauma to the head. The encephalopathy symptoms can include behavioral problems, mood problems, and problems with thinking. The disease often gets worse over time and can result in dementia. It is unclear if the risk of suicide is altered. Most documented cases have occurred in athletes involved in striking-based combat sports, such as boxing, kickboxing, mixed martial arts, and Muay Thai—hence its original name ''dementia pugilistica'' ( Latin for "fistfighter's dementia")—and contact sports such as American football, Australian rules football, professional wrestling, ice hockey, rugby, and association football (soccer), in semi-contact sports such as baseball and basketball, and military combat arms occupations. Other risk factors include being in the military, prior domestic violence, and repeated banging of the head. The exact amount of trauma required for the condit ...
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Spondylosis
Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense it refers to spinal osteoarthritis, the age-related wear and tear of the spinal column, which is the most common cause of spondylosis. The degenerative process in osteoarthritis chiefly affects the vertebral bodies, the neural foramina and the facet joints (facet syndrome). If severe, it may cause pressure on the spinal cord or nerve roots with subsequent sensory or motor disturbances, such as pain, paresthesia, imbalance, and muscle weakness in the limbs. When the space between two adjacent vertebrae narrows, compression of a nerve root emerging from the spinal cord may result in radiculopathy (sensory and motor disturbances, such as severe pain in the neck, shoulder, arm, back, or leg, accompanied by muscle weakness). Less commonly, direct pressure on the spinal cord (typically in the cervical spine) may result in myelopathy, characterized by global weakness, gait dysfunction, l ...
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Cardiff Royal Infirmary
Cardiff Royal Infirmary ( cy, Ysbyty Brenhinol Caerdydd) (also known as the CRI or YBC) is a hospital in central Cardiff, Wales. It is managed by the Cardiff and Vale University Health Board. History The hospital has its origins in the Cardiff Dispensary, which began on Newport Road in 1822. It became the Glamorganshire and Monmouthshire Infirmary and Dispensary in 1837. The current main hospital building facing Glossop Road, Adamsdown, was designed by Edwin Seward and opened in 1883. It became known as King Edward VII Hospital in 1911. During the First World War, the building was requisitioned by the War Office to create the 3rd Western General Hospital, a facility for the Royal Army Medical Corps to treat military casualties. It returned to its current name, Cardiff Royal Infirmary, in 1923. By the time it joined the National Health Service in 1948 it had expanded to become a 500-bed facility. The hospital ceased operating as a casualty facility in 1999, with the Accident and ...
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Queen Square, London
Queen Square is a garden square in the Bloomsbury district of central London. Many of its buildings are associated with medicine, particularly neurology. Construction Queen Square was originally constructed between 1716 and 1725. It was formed from the garden of the house of Sir John Cutler baronet (1608–1693), whose last surviving child, Lady Radnor, died in 1697 leaving no issue. It was left open to the north for the landscape formed by the hills of Hampstead and Highgate. Queen Charlotte and treatment for George III A statue contained within the square was misidentified as depicting Queen Anne. This statue is now believed to be a portrayal of Queen Charlotte, wife of King George III. George III was treated for mental illness in a house in Queen Square towards the end of his reign. The public house on the southwest corner of the square, called "the Queen’s Larder", was, according to legend, used by Queen Charlotte to store food for the king during his treatment. ...
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