|
Joannes Cassianus Pompe
Joannes Cassianus Pompe (9 September 1901, Utrecht – 15 April 1945, Sint Pancras) was a Dutch pathologist. In 1932, he characterized the condition now known as Glycogen storage disease type II. It is sometimes referred to as Pompe disease. Original disease description He studied medicine at the University of Utrecht, and trained as a pathologist in Amsterdam. During this time he came across the symptoms of what is now known as Pompe's disease, or Glycogen storage disease type II Glycogen storage disease type II, also called Pompe disease, is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of th ..., which he described in his 1932 publication ''Over idiopathische hypertrophie van het hart'' (English: ''About idiopathic hypertrophy of the heart''). On December 27, 1930, Dr. Pompe had carried out an autopsy on a 7-month old girl who had died of unkn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joannes Cassianus Pompe ROI Lowres
Joannes or John ( la, Iohannes; died 425) was western Roman emperor from 423 to 425. On the death of the Emperor Honorius (15 August 423), Theodosius II, the remaining ruler of the House of Theodosius, hesitated in announcing his uncle's death. In the ''interregnum'', Honorius's patrician at the time of his death, Castinus, elevated Joannes as emperor. History Joannes was a '' primicerius notariorum'' or senior civil servant at the time of his elevation. Procopius praised him as "both gentle and well-endowed with sagacity and thoroughly capable of valorous deeds." Unlike the Theodosian emperors, he tolerated all Christian sects and even the pagans. From the beginning, his control over the empire was insecure. In Gaul, his praetorian prefect was slain at Arles in an uprising of the soldiery there. And Bonifacius, '' comes'' of the Diocese of Africa, held back the grain fleet destined to Rome. "The events of Johannes' reign are as shadowy as its origins," writes Jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Utrecht
Utrecht ( , , ) is the List of cities in the Netherlands by province, fourth-largest city and a List of municipalities of the Netherlands, municipality of the Netherlands, capital and most populous city of the Provinces of the Netherlands, province of Utrecht (province), Utrecht. It is located in the eastern corner of the Randstad conurbation, in the very centre of mainland Netherlands, about 35 km south east of the capital Amsterdam and 45 km north east of Rotterdam. It has a population of 361,966 as of 1 December 2021. Utrecht's ancient city centre features many buildings and structures, several dating as far back as the High Middle Ages. It has been the religious centre of the Netherlands since the 8th century. It was the most important city in the Netherlands until the Dutch Golden Age, when it was surpassed by Amsterdam as the country's cultural centre and most populous city. Utrecht is home to Utrecht University, the largest university in the Netherlands, as well as seve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sint Pancras
Sint Pancras ( West Frisian: ''Sundebankreas'') is a town in the northwestern Netherlands. It is located in the municipality of Dijk en Waard, North Holland, about 5 km northeast of Alkmaar. History The village was founded in the 14th century, after the village of Vronen was destroyed by John I, Count of Holland, because West Friesland had revolted against his rule in 1297. It was first mentioned in 1433 as Pancraets, and refers to Pancras of Rome. The Dutch Reformed church is a single aisled cruciform church from the 16th century. In 1604, the tower burnt down and a lantern tower was constructed as a replacement. The ''polder'' mill A was built in 1663. It was one of ten wind mills to drain the excess water from the polder and the only one remaining. It became obsolete in 1926. In 2010, it was restored to working order, however the drainage canal had been filled up. In 2018, pipes were laid to allow the wind mill to operate again. Sint Pancras was home to 330 people in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycogen Storage Disease Type II
Glycogen storage disease type II, also called Pompe disease, is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme. It is the only glycogen storage disease with a defect in lysosomal metabolism, and the first glycogen storage disease to be identified, in 1932 by the Dutch pathologist J. C. Pompe. The build-up of glycogen causes progressive muscle weakness (myopathy) throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and the nervous system. Signs and symptoms Newborn The infantile form usually comes to medical attention within the first few months of life. The usual presenting features are cardiomegaly (92%), hypotonia (88%), cardiomyopathy (88%), respiratory distress (78%), muscle weakness (63%), feeding difficulties (57%) and failure to thrive (50%). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Utrecht University
Utrecht University (UU; nl, Universiteit Utrecht, formerly ''Rijksuniversiteit Utrecht'') is a public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2018, it had an enrollment of 31,801 students, and employed 7,191 faculty and staff. In 2018, 525 PhD degrees were awarded and 6,948 scientific articles were published. The 2018 budget of the university was €857 million. Utrecht University counts a number of distinguished scholars among its alumni and faculty, including 12 Nobel Prize laureates and 13 Spinoza Prize laureates. Utrecht University has been placed consistently in the top 100 universities in the world by prominent international ranking tables. The university is ranked as the best university in the Netherlands by the Shanghai Ranking of World Universities 2022, ranked 14th in Europe and 54th in the world. The university's motto is "Sol Iustitiae Illustra Nos", which means ''May the Sun of Righteous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amsterdam
Amsterdam ( , , , lit. ''The Dam on the River Amstel'') is the Capital of the Netherlands, capital and Municipalities of the Netherlands, most populous city of the Netherlands, with The Hague being the seat of government. It has a population of 907,976 within the city proper, 1,558,755 in the City Region of Amsterdam, urban area and 2,480,394 in the Amsterdam metropolitan area, metropolitan area. Located in the Provinces of the Netherlands, Dutch province of North Holland, Amsterdam is colloquially referred to as the "Venice of the North", for its large number of canals, now designated a World Heritage Site, UNESCO World Heritage Site. Amsterdam was founded at the mouth of the Amstel River that was dammed to control flooding; the city's name derives from the Amstel dam. Originally a small fishing village in the late 12th century, Amsterdam became a major world port during the Dutch Golden Age of the 17th century, when the Netherlands was an economic powerhouse. Amsterdam is th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1901 Births
Nineteen or 19 may refer to: * 19 (number), the natural number following 18 and preceding 20 * one of the years 19 BC, AD 19, 1919, 2019 Films * 19 (film), ''19'' (film), a 2001 Japanese film * Nineteen (film), ''Nineteen'' (film), a 1987 science fiction film Music * 19 (band), a Japanese pop music duo Albums * 19 (Adele album), ''19'' (Adele album), 2008 * ''19'', a 2003 album by Alsou * ''19'', a 2006 album by Evan Yo * ''19'', a 2018 album by MHD (rapper), MHD * ''19'', one half of the double album ''63/19'' by Kool A.D. * ''Number Nineteen'', a 1971 album by American jazz pianist Mal Waldron * XIX (EP), ''XIX'' (EP), a 2019 EP by 1the9 Songs * 19 (song), "19" (song), a 1985 song by British musician Paul Hardcastle. * "Nineteen", a song by Bad4Good from the 1992 album ''Refugee (Bad4Good album), Refugee'' * "Nineteen", a song by Karma to Burn from the 2001 album ''Almost Heathen''. * Nineteen (song), "Nineteen" (song), a 2007 song by American singer Billy Ray Cyrus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1945 Deaths
1945 marked the end of World War II and the fall of Nazi Germany and the Empire of Japan. It is also the only year in which Nuclear weapon, nuclear weapons Atomic bombings of Hiroshima and Nagasaki, have been used in combat. Events Below, the events of World War II have the "WWII" prefix. January * January 1 – WWII: ** Nazi Germany, Germany begins Operation Bodenplatte, an attempt by the ''Luftwaffe'' to cripple Allies of World War II, Allied air forces in the Low Countries. ** Chenogne massacre: German prisoners are allegedly killed by American forces near the village of Chenogne, Belgium. * January 6 – WWII: A German offensive recaptures Esztergom, Kingdom of Hungary (1920–1946), Hungary from the Russians. * January 12 – WWII: The Soviet Union begins the Vistula–Oder Offensive in Eastern Europe, against the German Army (Wehrmacht), German Army. * January 13 – WWII: The Soviet Union begins the East Prussian Offensive, to eliminate German forces in East Pruss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dutch Pathologists
Dutch commonly refers to: * Something of, from, or related to the Netherlands * Dutch people () * Dutch language () Dutch may also refer to: Places * Dutch, West Virginia, a community in the United States * Pennsylvania Dutch Country People Ethnic groups * Germanic peoples, the original meaning of the term ''Dutch'' in English ** Pennsylvania Dutch, a group of early Germanic immigrants to Pennsylvania *Dutch people, the Germanic group native to the Netherlands Specific people * Dutch (nickname), a list of people * Johnny Dutch (born 1989), American hurdler * Dutch Schultz (1902–1935), American mobster born Arthur Simon Flegenheimer * Dutch Mantel, ring name of American retired professional wrestler Wayne Maurice Keown (born 1949) * Dutch Savage, ring name of professional wrestler and promoter Frank Stewart (1935–2013) Arts, entertainment, and media Fictional characters * Dutch (''Black Lagoon''), an African-American character from the Japanese manga and anime ''Black L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dutch Resistance Members
Dutch commonly refers to: * Something of, from, or related to the Netherlands * Dutch people () * Dutch language () Dutch may also refer to: Places * Dutch, West Virginia, a community in the United States * Pennsylvania Dutch Country People Ethnic groups * Germanic peoples, the original meaning of the term ''Dutch'' in English ** Pennsylvania Dutch, a group of early Germanic immigrants to Pennsylvania *Dutch people, the Germanic group native to the Netherlands Specific people * Dutch (nickname), a list of people * Johnny Dutch (born 1989), American hurdler * Dutch Schultz (1902–1935), American mobster born Arthur Simon Flegenheimer * Dutch Mantel, ring name of American retired professional wrestler Wayne Maurice Keown (born 1949) * Dutch Savage, ring name of professional wrestler and promoter Frank Stewart (1935–2013) Arts, entertainment, and media Fictional characters * Dutch (''Black Lagoon''), an African-American character from the Japanese manga and anime ''Black L ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dutch Civilians Killed In World War II
Dutch commonly refers to: * Something of, from, or related to the Netherlands * Dutch people () * Dutch language () Dutch may also refer to: Places * Dutch, West Virginia, a community in the United States * Pennsylvania Dutch Country People Ethnic groups * Germanic peoples, the original meaning of the term ''Dutch'' in English ** Pennsylvania Dutch, a group of early Germanic immigrants to Pennsylvania *Dutch people, the Germanic group native to the Netherlands Specific people * Dutch (nickname), a list of people * Johnny Dutch (born 1989), American hurdler * Dutch Schultz (1902–1935), American mobster born Arthur Simon Flegenheimer * Dutch Mantel, ring name of American retired professional wrestler Wayne Maurice Keown (born 1949) * Dutch Savage, ring name of professional wrestler and promoter Frank Stewart (1935–2013) Arts, entertainment, and media Fictional characters * Dutch (''Black Lagoon''), an African-American character from the Japanese manga and anime ''Blac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Utrecht")
.jpg "Click for more on -> Amsterdam")
