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Isobucaine
Isobucaine is a local anesthetic. Synthesis The reductive amination between aminomethyl propanol (1) and isobutanal 8-84-2(2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamineCID:18315986(3). Acylation of the amine with benzoyl chloride Benzoyl chloride, also known as benzenecarbonyl chloride, is an organochlorine compound with the formula . It is a colourless, fuming liquid with an irritating odour, and consists of a benzene ring () with an acyl chloride () substituent. It is ... 8-88-4hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5). See also * List of local anesthetics References Local anesthetics Benzoate esters {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isobucaine Synthesis
Isobucaine is a local anesthetic. Synthesis The reductive amination between aminomethyl propanol (1) and isobutanal 8-84-2(2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamineCID:18315986(3). Acylation of the amine with benzoyl chloride 8-88-4hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5). See also *List of local anesthetics This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest. See also * 4-Aminobenzoic acid * Amino amide * Amino esters * Anesthesia * Anest ... References Local anesthetics Benzoate esters {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminomethyl Propanol
Aminomethyl propanol is an organic compound with the formula H2NC(CH3)2CH2OH. It is colorless liquid that is classified as an alkanolamine. It is a useful buffer and a precursor to numerous other organic compounds. Synthesis Aminomethyl propanol can be produced by the hydrogenation of 2-aminoisobutyric acid or its esters. Properties Aminomethyl propanol is soluble in water and about the same density as water. Uses Aminomethyl propanol is used for the preparation of buffer solutions. It is a component of the drugs ambuphylline and pamabrom. It is also used in cosmetics. It is a precursor to oxazolines via its reaction with acyl chlorides. Via sulfation of the alcohol, the compound is also a precursor to 2,2-dimethylaziridine. It is used in the synthesis of Fepradinol & G-130 G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine) is a drug with stimulant and anorectic effects, related to phenmetrazine. Structural analogs Compounds related to G-130 and radafaxin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Local Anesthetics
This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest. See also * 4-Aminobenzoic acid * Amino amide * Amino esters * Anesthesia * Anesthetic * Brachial plexus block * Cocaine analogues: local anesthetics * Dental anesthesia * Dibucaine number * Epidural * Intravenous regional anesthesia * Local anesthesia * Local anesthetic with vasoconstrictor * Local anesthetic toxicity * Methemoglobin * Sodium channel blocker * Spinal anesthesia * Topical anesthesia * Veterinary anesthesia Veterinary anesthesia is anesthesia performed on non-human animals by a veterinarian or a Registered Veterinary Technician. Anesthesia is used for a wider range of circumstances in animals than in people, due to animals' inability to cooperate with ... References {{reflist Local anesthetics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Anesthetic
A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general anesthetic. When it is used on specific nerve pathways (local anesthetic nerve block), paralysis (loss of muscle power) also can be achieved. Examples Short Duration & Low Potency Procaine Chloroprocaine Medium Duration & Potency Lidocaine Prilocaine High Duration & Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic LAs are structurally related to cocaine. They differ from cocaine mainly in that they have a very low abuse potential and do not produce hypertension or (with few exceptions) vasoconstriction. They are used in various techniques of local anesthesia such as: * Topical anesthesia (surface) * Topical administration ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoyl Chloride
Benzoyl chloride, also known as benzenecarbonyl chloride, is an organochlorine compound with the formula . It is a colourless, fuming liquid with an irritating odour, and consists of a benzene ring () with an acyl chloride () substituent. It is mainly useful for the production of peroxides but is generally useful in other areas such as in the preparation of dyes, perfumes, pharmaceuticals, and resins. Preparation Benzoyl chloride is produced from benzotrichloride using either water or benzoic acid: :C6H5CCl3 + H2O -> C6H5COCl + 2 HCl :C6H5CCl3 + C6H5CO2H -> 2 C6H5COCl + HCl As with other acyl chlorides, it can be generated from the parent acid and standard chlorinating agents such as phosphorus pentachloride, thionyl chloride, and oxalyl chloride. It was first prepared by treatment of benzaldehyde with chlorine. An early method for production of benzoyl chloride involved chlorination of benzyl alcohol. Reactions It reacts with water to produce hydrochloric acid and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Anesthetics
A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general anesthetic. When it is used on specific nerve pathways (local anesthetic nerve block), paralysis (loss of muscle power) also can be achieved. Examples Short Duration & Low Potency Procaine Chloroprocaine Medium Duration & Potency Lidocaine Prilocaine High Duration & Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic LAs are structurally related to cocaine. They differ from cocaine mainly in that they have a very low abuse potential and do not produce hypertension or (with few exceptions) vasoconstriction. They are used in various techniques of local anesthesia such as: * Topical anesthesia (surface) * Topical administration ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
