Isobucaine Synthesis on:
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Isobucaine is a
The reductive amination between
CID:18315986
(3). Acylation of the amine with
local anesthetic
A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general an ...
.Synthesis
The reductive amination between aminomethyl propanol
Aminomethyl propanol is an organic compound with the formula H2NC(CH3)2CH2OH. It is colorless liquid that is classified as an alkanolamine. It is a useful buffer and a precursor to numerous other organic compounds.
Synthesis
Aminomethyl propano ...
(1) and isobutanal 8-84-2(2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamineCID:18315986
(3). Acylation of the amine with
benzoyl chloride
Benzoyl chloride, also known as benzenecarbonyl chloride, is an organochlorine compound with the formula . It is a colourless, fuming liquid with an irritating odour, and consists of a benzene ring () with an acyl chloride () substituent. It i ...
8-88-4hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5).See also
*List of local anesthetics
This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest.
See also
* 4-Aminobenzoic acid
* Amino amide
* Amino esters
* Anesthesia
* Anest ...
References
Local anesthetics Benzoate esters {{organic-compound-stub